{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:52:51Z","timestamp":1791183171674,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ) has developed resistance to multiple antibiotic classes, complicating treatment in both human and veterinary medicine. This study assesses the prevalence of antimicrobial resistance and antimicrobial resistance genes in\n                    <jats:italic>E. coli<\/jats:italic>\n                    in Iran, within a One Health framework encompassing humans, animals, foods, and the environment. We systematically searched Scopus, Google Scholar, Magiran, PubMed, Scientific Information Database Library (SID), and Web of Science, using keywords related to AMR and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , restricting to English and Persian publications from 2010 to January 2025. The risk of bias was evaluated using the JBI checklist for prevalence studies. Pooled prevalence and 95% confidence intervals (CIs) were calculated for each antibiotic using random\u2010effects models. A total of 368 studies were included in the meta\u2010analysis. The highest resistance was observed in the Classes of Penicillins (71.7, 95% CI: 65.6\u201376.6) and the lowest for Fosfomycins (6.8, 95% CI: 5.2\u20138.5). Resistance to Ceftizoxime, Ertapenem, Streptomycin, Piperacillin\u2010Tazobactam, and Colistin increased over time. Phenotypically, 47.2%, 20.2%, and 14.1% of\n                    <jats:italic>E. coli<\/jats:italic>\n                    isolates were identified as extended\u2010spectrum \u03b2\u2010lactamase\u2010producing (ESBL), AmpC, and metallo\u2010beta\u2010lactamase (MBL) producing, respectively. Among ESBL\u2010producing isolates, the prevalence of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>CTX\u2010M<\/jats:sub>\n                    ,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>TEM<\/jats:sub>\n                    , and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>SHV<\/jats:sub>\n                    genes was 68.2%, 58.5%, and 24.4%, respectively. The high prevalence of AMR highlights the critical need for robust antimicrobial stewardship within a One Health framework to preserve antibiotic efficacy. Our study provides essential baseline data across human, animal, and environmental sectors in Iran, forming a basis for future One Health strategies and policy\u2010making.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70420","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:36:53Z","timestamp":1791182213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iran's\n                    <i>Escherichia coli<\/i>\n                    AMR Landscape (2010\u20132025): A One Health Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1965-4402","authenticated-orcid":false,"given":"Arezoo","family":"Dehghan","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, WHO Collaborating Center for Vector\u2010Borne Diseases, Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Arabian","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, WHO Collaborating Center for Vector\u2010Borne Diseases, Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9270-9652","authenticated-orcid":false,"given":"Zahra","family":"Tahmasebi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, WHO Collaborating Center for Vector\u2010Borne Diseases, Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1693-533X","authenticated-orcid":false,"given":"Aliasghar","family":"Fakhri\u2010Demeshghieh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, WHO Collaborating Center for Vector\u2010Borne Diseases, Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Baseri","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Faculty of Medical Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1997-517X","authenticated-orcid":false,"given":"Ehsan","family":"Mostafavi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, WHO Collaborating Center for Vector\u2010Borne Diseases, Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-147X","authenticated-orcid":false,"given":"Farzad","family":"Badmasti","sequence":"additional","affiliation":[{"name":"Department of Bacteriology Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faranak","family":"Abnaroodhelleh","sequence":"additional","affiliation":[{"name":"Head of the Control and Supervision Group on the Production of Medicines and Biological Materials of the Iran Veterinary Organization  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Seifi","sequence":"additional","affiliation":[{"name":"Center for Communicable Diseases Control (CDC) Ministry of Health and Medical Education  Tehran Iran"},{"name":"Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Infectious Diseases Department, Imam Khomeini Hospital Complex Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-2846","authenticated-orcid":false,"given":"Fahimeh","family":"Bagheri Amiri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, WHO Collaborating Center for Vector\u2010Borne Diseases, Research Centre for Emerging and Reemerging Infectious Diseases Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3390\/antibiotics12060951","article-title":"An Evaluation of the Impact of Increasing the Awareness of the WHO Access, Watch, and Reserve (AWaRe) Antibiotics Classification on Knowledge, Attitudes, and Hospital Antibiotic Prescribing Practices","volume":"12","author":"Abu\u2010Ajaleh S.","year":"2023","journal-title":"Antibiotics (USSR)"},{"issue":"3","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.54660\/IJMBHR.2025.6.3.62-76","article-title":"The Global Threat of Antimicrobial Resistance: A Microbiological Review","volume":"6","author":"Aladeeb M.","year":"2025","journal-title":"International Journal of Medical and All Body Health Research"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","unstructured":"Alijaniha M. M.Alijaniha andY.VahdaniAntibiotic Prescribing Trends Among Iranian General Practitioners During COVID\u201019: Impacts on Antimicrobial Resistance.2025.","DOI":"10.21203\/rs.3.rs-6378570\/v1"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"1","article-title":"Escherichia coli in Iran: An Overview of Antibiotic Resistance: A Review Article","volume":"47","author":"Alizade H.","year":"2018","journal-title":"Iranian Journal of Public Health"},{"issue":"1","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.sjbs.2019.09.020","article-title":"Prevalence and Molecular Characteristics of Sequence Type 131 Clone Among Clinical Uropathogenic Escherichia coli Isolates in Riyadh, Saudi Arabia","volume":"27","author":"Alqasim A.","year":"2020","journal-title":"Saudi Journal of Biological Sciences"},{"issue":"1","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.34172\/ajcmi.3474","article-title":"Evaluation of Antimicrobial Susceptibility in Extended\u2010Spectrum \u03b2\u2010Lactamase Producing Escherichia coli Isolates From Patients in Northwest Iran","volume":"11","author":"Bahloli M.","year":"2024","journal-title":"Avicenna Journal of Clinical Microbiology and Infection"},{"issue":"4","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1086\/669865","article-title":"Escherichia coli Sequence Type 131 Is a Dominant, Antimicrobial\u2010Resistant Clonal Group Associated With Healthcare and Elderly Hosts","volume":"34","author":"Banerjee R.","year":"2013","journal-title":"Infection Control and Hospital Epidemiology"},{"issue":"1","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"fux053","DOI":"10.1093\/femsre\/fux053","article-title":"Environmental Factors Influencing the Development and Spread of Antibiotic Resistance","volume":"42","author":"Bengtsson\u2010Palme J.","year":"2018","journal-title":"FEMS Microbiology Reviews"},{"issue":"8","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/jac\/dkx146","article-title":"Global Epidemiology of CTX\u2010M \u03b2\u2010lactamases: Temporal and Geographical Shifts in Genotype","volume":"72","author":"Bevan E. R.","year":"2017","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"3","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","DOI":"10.1093\/jacamr\/dlac048","article-title":"Comparison of the Global Prevalence and Trend of Human Intestinal Carriage of ESBL\u2010Producing Escherichia coli Between Healthcare and Community Settings: A Systematic Review and Meta\u2010Analysis","volume":"4","author":"Bezabih Y. 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