{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:50:00Z","timestamp":1791442200676,"version":"4.3.3"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Endophytic fungi are recognized as rich sources of bioactive secondary metabolites with promising pharmaceutical applications. In this study, five endophytic fungal isolates were obtained from\n                    <jats:italic>Deverra tortuosa<\/jats:italic>\n                    and evaluated for antimicrobial activity for the first time. Among them, isolate AA1 showed the highest antimicrobial potential and was identified as\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    (GenBank accession no. PX273401.1) through morphological and molecular analyses. Phytochemical analysis revealed high levels of flavonoids (496.5\u2009\u00b5g\/mL), tannins (260.7\u2009\u00b5g\/mL), phenolics (214.93\u2009\u00b5g\/mL), and alkaloids (26.45\u2009\u00b5g\/mL). GC\u2013MS profiling detected several bioactive metabolites, with hexadecenoic acid, docosene, octadecanol, isochiapin B, octadecenoic acid, and octacosanol as major constituents. The fungal extract exhibited potent antibacterial activity against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    , and\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    , each with a minimum inhibitory concentration (MIC) of 62.5\u2009\u00b5g\/mL. It also inhibited biofilm formation by 26.9:55.1% at \u00bd MIC and demonstrated notable antioxidant activity, with half maximal inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) values of 167.6\u2009\u00b5g\/mL (DPPH) and 137.8\u2009\u00b5g\/mL (ABTS). Cytotoxicity assays confirmed relatively low toxicity toward normal Wi\u201038 and Vero cell lines, while significant antiproliferative activity was observed against MCF\u20107 and HepG2 cancer cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 78.7 and 29.5\u2009\u00b5g\/mL, respectively, indicating favorable selectivity. Molecular docking supported these biological activities, identifying hexadecenoic acid as the strongest ligand against DNA gyrase subunit B (GyrB) and estrogen receptor alpha (ER\u03b1), while isochiapin B also showed strong affinity toward ER\u03b1. These findings demonstrate that\n                    <jats:italic>A. niger<\/jats:italic>\n                    from\n                    <jats:italic>D. tortuosa<\/jats:italic>\n                    is a promising source of multifunctional bioactive metabolites with antimicrobial, antioxidant, and anticancer potential for future pharmaceutical applications.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70430","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:00:15Z","timestamp":1791439215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Aspergillus niger<\/i>\n                    as a New Endophytic Fungus From\n                    <i>Deverra tortuosa<\/i>\n                    : Phytochemical Profile, Molecular Docking, Antimicrobial, Antibiofilm, Antioxidant, and Anticancer Activities"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-8586","authenticated-orcid":false,"given":"Samy","family":"Selim","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences Jouf University Sakaka Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-3606","authenticated-orcid":false,"given":"Amr H.","family":"Hashem","sequence":"additional","affiliation":[{"name":"Botany and Microbiology Department, Faculty of Science Al\u2010Azhar University Nasr City, Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-5168","authenticated-orcid":false,"given":"Amer Morsy","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Botany and Microbiology Department, Faculty of Science Al\u2010Azhar University Nasr City, Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed H.","family":"Sharaf","sequence":"additional","affiliation":[{"name":"Botany and Microbiology Department, Faculty of Science Al\u2010Azhar University Nasr City, Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-6008","authenticated-orcid":false,"given":"Samiah Hamad","family":"Al\u2010Mijalli","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Sciences Princess Nourah bint Abdulrahman University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Aladhadh","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition, College of Agriculture and Food Qassim University Buraydah Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad M.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Qassim University Buraydah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed H.","family":"Alruhaili","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Immunology, Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Special Infectious Agents Unit, King Fahad Medical Research Center King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hattan S.","family":"Gattan","sequence":"additional","affiliation":[{"name":"Special Infectious Agents Unit, King Fahad Medical Research Center King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa A.","family":"Kashmiry","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of science University of Jeddah Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-4530","authenticated-orcid":false,"given":"Mohammed","family":"Aufy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-981-97-7312-1_2","volume-title":"Fungal Endophytes Volume I: Biodiversity and Bioactive Materials","author":"Abdelaziz A. M.","year":"2025"},{"issue":"6","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3390\/microorganisms11061487","article-title":"Efficient Role of Endophytic Aspergillus terreus in Biocontrol of Rhizoctonia solani Causing Damping\u2010Off Disease of Phaseolus vulgaris and Vicia faba","volume":"11","author":"Abdelaziz A. M.","year":"2023","journal-title":"Microorganisms"},{"issue":"1","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40529-022-00364-7","article-title":"Biostimulation of Tomato Growth and Biocontrol of Fusarium Wilt Disease Using Certain Endophytic Fungi","volume":"63","author":"Abdelaziz A. M.","year":"2022","journal-title":"Botanical Studies"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.21608\/mid.2025.445414.3494"},{"issue":"1","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1186\/s12866-026-05044-1","article-title":"Solvent Alternation of the Antimicrobial, Antioxidant, Anticancer Activities and Chemical Profiles of Trametes hirsuta (Wulfen) Lloyd","volume":"26","author":"Ahmed Y. M.","year":"2026","journal-title":"BMC Microbiology"},{"issue":"11","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s11274-023-03752-8","article-title":"Molecular Docking and Antibacterial Activity of Sargassum Fusiforme Extracts Against Major Coral Pathogens","volume":"39","author":"Ahmed N.","year":"2023","journal-title":"World Journal of Microbiology and Biotechnology"},{"key":"e_1_2_11_8_1","volume-title":"Atlas of the Population of Kuwait","author":"Al\u2010Faraj M. S.","year":"1992"},{"key":"e_1_2_11_9_1","first-page":"130","volume-title":"Therapeutic Medicinal Plants: From Lab to the Market","author":"Ara\u00fajo S.","year":"2016"},{"key":"e_1_2_11_10_1","article-title":"Immune and Physiological Modulation by Endophytic Fungi in Fusarium oxysporum f. sp. lycopersici\u2013Infected Plants","author":"Attia M. S.","year":"2025","journal-title":"Physiological and Molecular Plant Pathology"},{"issue":"1","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.21608\/ejbo.2024.279261.2777","article-title":"Fungal Endophytes as Promising Antibacterial Agents Against Ralstonia solanacearum, the Cause of Wilt Disease in Potato Plants","volume":"65","author":"Attia M. S.","year":"2025","journal-title":"Egyptian Journal of Botany"},{"issue":"3","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","DOI":"10.15835\/nbha51313312","article-title":"Eco\u2010Friendly Preparation of Thyme Essential Oil Nano Emulsion: Characterization, Antifungal Activity and Resistance of Fusarium Wilt Disease of Foeniculum vulgare","volume":"51","author":"Attia M. S.","year":"2023","journal-title":"Notulae Botanicae Horti Agrobotanici Cluj\u2010Napoca"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envexpbot.2021.104456","article-title":"Endophytic Aspergillus niger Reprograms the Physicochemical Traits of Tomato Under Cadmium and Chromium Stress","volume":"186","author":"Aziz L.","year":"2021","journal-title":"Environmental and Experimental Botany"},{"issue":"1","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.foodres.2010.10.001","article-title":"Total Phenolic Content and Antioxidant Capacity of Extracts Obtained From Six Important Fruit Residues","volume":"44","author":"Babbar N.","year":"2011","journal-title":"Food Research International"},{"issue":"1","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-75446-6","article-title":"Anticancer, Antimicrobial, Insecticidal and Molecular Docking of Sarcotrocheliol and Cholesterol From the Marine Soft Coral Sarcophyton Trocheliophorum","volume":"14","author":"Bashar M. A. E.","year":"2024","journal-title":"Scientific Reports"},{"key":"e_1_2_11_16_1","volume-title":"Plants in the Deserts of the Middle East","author":"Batanouny K. H.","year":"2000"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0065-2296(08)60008-7","article-title":"On the Nature and Genetic Basis for Resistance and Tolerance to Fungal Wilt Diseases of Plants","volume":"21","author":"Beckman C. H.","year":"1995","journal-title":"Advances in Botanical Research"},{"issue":"4","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.talanta.2010.02.025","article-title":"Solvent Effects on the Antioxidant Capacity of Lipophilic and Hydrophilic Antioxidants Measured by CUPRAC, ABTS\/Persulphate and FRAP Methods","volume":"81","author":"\u00c7elik S. E.","year":"2010","journal-title":"Talanta"},{"issue":"1","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","DOI":"10.1111\/apm.70140","article-title":"Inhibitory Effects of Sapindus mukorossi Gaertn. Extract on Biofilm Formation and Quorum Sensing in Pseudomonas aeruginosa: A Natural Alternative to Combat Bacterial Resistance","volume":"134","author":"Choudhury S. R.","year":"2026","journal-title":"APMIS"},{"key":"e_1_2_11_20_1","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically: Approved Standard","author":"Cockerill F. R.","year":"2012"},{"issue":"2","key":"e_1_2_11_21_1","first-page":"197","article-title":"Climate Change Effects on Beneficial Plant\u2013Microorganism Interactions","volume":"73","author":"Compant S.","year":"2010","journal-title":"FEMS Microbiology Ecology"},{"issue":"1","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/(SICI)1520-6327(1996)32:1<3::AID-ARCH2>3.0.CO;2-1","article-title":"Antinutritive and Toxic Components of Plant Defense Against Insects","volume":"32","author":"Duffey S. S.","year":"1996","journal-title":"Archives of Insect Biochemistry and Physiology"},{"issue":"2","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.21608\/mb.2026.492066.1599","article-title":"Medical and Therapeutic Potential of Endophytic Streptomyces griseus for Combating Multidrug\u2010Resistant Infections and Enhancing Wound Repair in Cancer Patients","volume":"11","author":"Elebiary D. M.","year":"2026","journal-title":"Microbial Biosystems"},{"issue":"1","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4014\/jmb.2211.11026","article-title":"Antagonistic Potentiality of Actinomycete\u2010Derived Extract With Anti\u2010Biofilm, Antioxidant, and Cytotoxic Capabilities as a Natural Combating Strategy for Multidrug\u2010Resistant ESKAPE Pathogens","volume":"33","author":"El\u2010Sayed M. H.","year":"2022","journal-title":"Journal of Microbiology and Biotechnology"},{"issue":"6","key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1080\/0972060X.2025.2606094","article-title":"Essential Oil From Acacia nilotica Leaves: Integrated GC\u2013MS\/NMR Profiling, Antibacterial and Antibiofilm Assays, and Computational Evaluation of Key Constituents","volume":"28","author":"Elshamy A. I.","year":"2025","journal-title":"Journal of Essential Oil Bearing Plants"},{"issue":"1","key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13765-025-00982-2","article-title":"Multifunctional Properties of Phlomis aurea Extracts: In\u2010Vitro Antioxidant, Antimicrobial, Anticancer, Potent Repellency Against Two Mosquito Vectors and Molecular Docking Studies","volume":"68","author":"El\u2010Tabakh M. A. M.","year":"2025","journal-title":"Applied Biological Chemistry"},{"issue":"2","key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/biom15020266","article-title":"Impeding Biofilm\u2010Forming Mediated Methicillin\u2010Resistant Staphylococcus aureus and Virulence Genes Using a Biosynthesized Silver Nanoparticles\u2013Antibiotic Combination","volume":"15","author":"Fareid M. A.","year":"2025","journal-title":"Biomolecules"},{"key":"e_1_2_11_28_1","first-page":"65","volume-title":"Interactions of Yeasts, Moulds, and Antifungal Agents: How to Detect Resistance","author":"Fothergill A. W.","year":"2011"},{"issue":"40","key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"8765","DOI":"10.1021\/acs.jafc.5b03839","article-title":"Use and Abuse of the DPPH\u00b7 Radical","volume":"63","author":"Foti M. C.","year":"2015","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_11_30_1","volume-title":"In Vitro Arachidonic Acid Metabolism by Polymicrobial Biofilms of Candida albicans and Pseudomonas aeruginosa","author":"Fourie R.","year":"2016"},{"issue":"2","key":"e_1_2_11_31_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/08927014.2015.1134515","article-title":"Mini\u2010Review: Biofilm Responses to Oxidative Stress","volume":"32","author":"Gambino M.","year":"2016","journal-title":"Biofouling"},{"issue":"5","key":"e_1_2_11_32_1","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.3390\/molecules30051028","article-title":"Endophytic Fungal Diversity and Its Interaction Mechanism With Medicinal Plants","volume":"30","author":"Gao Y.","year":"2025","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"45","key":"e_1_2_11_33_1","doi-asserted-by":"crossref","first-page":"43024","DOI":"10.1021\/acsomega.3c06246","article-title":"Phytochemical Composition, Antioxidant, Antimicrobial, Antibiofilm, and Antiquorum Sensing Potential of Methanol Extract and Essential Oil From Acanthus polystachyus Delile (Acanthaceae)","volume":"8","author":"Getahun M.","year":"2023","journal-title":"ACS Omega"},{"key":"e_1_2_11_34_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-981-15-2361-8_5","volume-title":"Plant\u2010Derived Bioactives: Chemistry and Mode of Action","author":"Guti\u00e9rrez\u2010Grijalva E. P.","year":"2020"},{"issue":"10","key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1139\/m97-131","article-title":"Bacterial Endophytes in Agricultural Crops","volume":"43","author":"Hallmann J.","year":"1997","journal-title":"Canadian Journal of Microbiology"},{"issue":"3","key":"e_1_2_11_36_1","first-page":"297","article-title":"Endophytic Fungi Trigger Immune and Molecular Defenses Against Fusarium Wilt in Tomato Plants","volume":"66","author":"Hasan F. F.","year":"2026","journal-title":"Egyptian Journal of Botany"},{"key":"e_1_2_11_37_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmpp.2026.103282","article-title":"Integrated Biocontrol of Fusarium Wilt in Tomato via Metabolic Responses and Defense Activation by Plant Growth\u2010Promoting Fungi","author":"Hasan F. F.","year":"2026","journal-title":"Physiological and Molecular Plant Pathology"},{"issue":"7","key":"e_1_2_11_38_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/separations10070395","article-title":"Bacterial Endophytes From Moringa oleifera Leaves as a Promising Source for Bioactive Compounds","volume":"10","author":"Hashem A. H.","year":"2023","journal-title":"Separations"},{"issue":"4","key":"e_1_2_11_39_1","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3390\/agronomy13041114","article-title":"Potential Impacts of Clove Essential Oil Nanoemulsion as Bio Fungicides Against Neoscytalidium Blight Disease of Carum carvi L","volume":"13","author":"Hashem A. H.","year":"2023","journal-title":"Agronomy"},{"issue":"9","key":"e_1_2_11_40_1","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1021\/jf980154m","article-title":"Characterization of the Action of Selected Essential Oil Components on Gram\u2010Negative Bacteria","volume":"46","author":"Helander I. M.","year":"1998","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_11_41_1","volume-title":"Studies on Fatty Acid and Acylated Homoserine Lactone Biosynthesis in Pseudomonas aeruginosa","author":"Hoang T. T.","year":"2000"},{"issue":"5","key":"e_1_2_11_42_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S1684-1182(10)60070-9","article-title":"Consensus Statement on the Adherence to Clinical and Laboratory Standards Institute (CLSI) Antimicrobial Susceptibility Testing Guidelines (CLSI\u20102010 and CLSI\u20102010\u2010Update) for Enterobacteriaceae in Clinical Microbiology Laboratories in Taiwan","volume":"43","author":"Hsueh P.\u2010R.","year":"2010","journal-title":"Journal of Microbiology, Immunology and Infection"},{"key":"e_1_2_11_43_1","volume-title":"Drug Screening for Kinetoplastids Diseases. A Training Manual for Screening in Neglected Diseases","author":"Ioset J.\u2010R.","year":"2009"},{"key":"e_1_2_11_44_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1379602","article-title":"Bioprospecting of Aspergillus sp. as a Promising Repository for Anti\u2010Cancer Agents: A Comprehensive Bibliometric Investigation","volume":"15","author":"Jangid H.","year":"2024","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_11_45_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115389","article-title":"Bacterial Biofilm Inhibitors: An Overview","volume":"264","author":"Kalia V. C.","year":"2023","journal-title":"Ecotoxicology and Environmental Safety"},{"issue":"20","key":"e_1_2_11_46_1","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.3390\/cells11203292","article-title":"Endophyte\u2010Mediated Stress Tolerance in Plants: A Sustainable Strategy to Enhance Resilience and Assist Crop Improvement","volume":"11","author":"Kamran M.","year":"2022","journal-title":"Cells"},{"issue":"3","key":"e_1_2_11_47_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/lam.13414","article-title":"Fungal Endophytes From Leaves of Avicennia marina Growing in Semi\u2010Arid Environment as a Promising Source for Bioactive Compounds","volume":"72","author":"Khalil A. M. A.","year":"2021","journal-title":"Letters in Applied Microbiology"},{"key":"e_1_2_11_48_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-026-42733-3","article-title":"Physicochemical Optimization of Zinc Oxide Nanoparticles Enhances Their Antimicrobial and Anticancer Activities via RmpA, fnbA, cna, and LuxS Gene Expression Suppression","volume":"16","author":"Khedr M.","year":"2026","journal-title":"Scientific Reports"},{"issue":"1","key":"e_1_2_11_49_1","article-title":"Antioxidant and Anti\u2010Inflammatory Activity Determination of One Hundred Kinds of Pure Chemical Compounds Using Offline and Online Screening HPLC Assay","volume":"2015","author":"Lee K. J.","year":"2015","journal-title":"Evidence\u2010Based Complementary and Alternative Medicine"},{"key":"e_1_2_11_50_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.928967","article-title":"Biosynthetic Mechanisms of Secondary Metabolites Promoted by the Interaction Between Endophytes and Plant Hosts","volume":"13","author":"Li Z.","year":"2022","journal-title":"Frontiers in Microbiology"},{"issue":"8","key":"e_1_2_11_51_1","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1021\/np200381u","article-title":"Nigerapyrones A\u2013H, \u03b1\u2010Pyrone Derivatives From the Marine Mangrove\u2010Derived Endophytic Fungus Aspergillus niger MA\u2010132","volume":"74","author":"Liu D.","year":"2011","journal-title":"Journal of Natural Products"},{"issue":"16","key":"e_1_2_11_52_1","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.3390\/foods15162867","article-title":"Lauric Acid Microemulsions Inhibit Staphylococcus aureus Through Cell Membrane Disruption and Potential Interference With Peptidoglycan Biosynthesis","volume":"15","author":"Ma P.","year":"2026","journal-title":"Foods"},{"key":"e_1_2_11_53_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxic Assay","volume":"65","author":"Mosdam T.","year":"1983","journal-title":"Journal of Immunological Methods"},{"issue":"2","key":"e_1_2_11_54_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/microbiolspec.VMBF-0016-2015","article-title":"Mechanisms of Antibiotic Resistance","volume":"4","author":"Munita J. M.","year":"2016","journal-title":"Microbiology Spectrum"},{"issue":"4","key":"e_1_2_11_55_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/microbiolres17040065","article-title":"Biofilm and Quorum\u2010Sensing Inhibition by Novel Bacillus xiamenensis MM07 Endophytic Isolate From Paederia foetida to Combat Pseudomonas aeruginosa","volume":"17","author":"Nath M. J.","year":"2026","journal-title":"Microbiology Research"},{"key":"e_1_2_11_56_1","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: An Overview","volume":"5","author":"Panche A. N.","year":"2016","journal-title":"Journal of Nutritional Science"},{"issue":"5","key":"e_1_2_11_57_1","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1007\/s12010-024-05098-9","article-title":"An Update of Fungal Endophyte Diversity and Strategies for Augmenting Therapeutic Potential of Their Potent Metabolites: Recent Advancement","volume":"197","author":"Prajapati C.","year":"2025","journal-title":"Applied Biochemistry and Biotechnology"},{"issue":"14","key":"e_1_2_11_58_1","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.3390\/foods13142253","article-title":"Anticancer Potential of Flavonoids: Their Role in Cancer Prevention and Health Benefits","volume":"13","author":"Pyo Y.","year":"2024","journal-title":"Foods"},{"key":"e_1_2_11_59_1","volume-title":"1962\u20131963. Nouvelle flore de l\u201f Alg\u00e9rie et des r\u00e9gions d\u00e9sertiques m\u00e9ridionales","author":"Quezal P.","year":"1996"},{"issue":"4","key":"e_1_2_11_60_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S1360-1385(97)01018-2","article-title":"Antioxidant Properties of Phenolic Compounds","volume":"2","author":"Rice\u2010Evans C.","year":"1997","journal-title":"Trends in Plant Science"},{"key":"e_1_2_11_61_1","first-page":"3753","article-title":"Phytochemical Analysis, Antimicrobial, Antioxidant, and Cytotoxicity Activities of Schinus molle (L.) Extracts","volume":"15","author":"Shehata M. E.","year":"2024","journal-title":"Biomass Conversion and Biorefinery"},{"issue":"12","key":"e_1_2_11_62_1","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1016\/0031-9422(91)83426-L","article-title":"Antimicrobial Properties of Tannins","volume":"30","author":"Scalbert A.","year":"1991","journal-title":"Phytochemistry"},{"issue":"2","key":"e_1_2_11_63_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4103\/epj.epj_10_20","article-title":"Evaluation of the Antivirulence Activity of Ethyl Acetate Extract of Deverra tortuosa (Desf) Against Candida albicans","volume":"19","author":"Sharaf M.","year":"2020","journal-title":"Egyptian Pharmaceutical Journal"},{"issue":"4","key":"e_1_2_11_64_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s12668-026-02484-x","article-title":"Improved Antimicrobial Activity of Nano\u2010Emulsified Tea Tree Oil Against Multi\u2010Drug\u2010Resistant Pathogens","volume":"16","author":"Sharaf M. H.","year":"2026","journal-title":"BioNanoScience"},{"key":"e_1_2_11_65_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejbt.2024.07.003","article-title":"Antimicrobial Characteristics of Endophytic Aspergillus terreus and Acute Oral Toxicity Analysis","volume":"72","author":"Shehabeldine A. M.","year":"2024","journal-title":"Electronic Journal of Biotechnology"},{"issue":"3","key":"e_1_2_11_66_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/medicina61030515","article-title":"Anti\u2010Virulence Properties of Curcumin\/CuO\u2010NPs and Their Role in Accelerating Wound Healing In Vivo","volume":"61","author":"Shehabeldine A. M.","year":"2025","journal-title":"Medicina"},{"issue":"1","key":"e_1_2_11_67_1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1080\/2314808X.2023.2283268","article-title":"Molecular Docking and Insecticidal Activity of Pyrus communis L. Extracts Against Disease Vector, Musca domestica L.(Diptera: Muscidae)","volume":"10","author":"Shehata A. Z. I.","year":"2023","journal-title":"Egyptian Journal of Basic and Applied Sciences"},{"key":"e_1_2_11_68_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmpp.2024.102287","article-title":"Protective Role of Biomass Endophytic Fungi to Enhance Potato Plant Responses Against Wilt Disease Caused by Ralstonia solanacearum","volume":"131","author":"Soliman E. A.","year":"2024","journal-title":"Physiological and Molecular Plant Pathology"},{"issue":"2","key":"e_1_2_11_69_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3390\/microorganisms10020360","article-title":"Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery","volume":"10","author":"Tiwari P.","year":"2022","journal-title":"Microorganisms"},{"issue":"3","key":"e_1_2_11_70_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0891-5849(95)02047-0","article-title":"Structural Aspects of Antioxidant Activity of Flavonoids","volume":"20","author":"Van Acker S. A. B. E.","year":"1996","journal-title":"Free Radical Biology and Medicine"},{"issue":"1","key":"e_1_2_11_71_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0022-1759(94)90034-5","article-title":"A Tetrazolium\u2010Based Colorimetric MTT Assay to Quantitate Human Monocyte Mediated Cytotoxicity Against Leukemic Cells From Cell Lines and Patients With Acute Myeloid Leukemia","volume":"174","author":"Van de Loosdrecht A. A.","year":"1994","journal-title":"Journal of Immunological Methods"},{"key":"e_1_2_11_72_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2026.1734749","article-title":"Breaking the Outer Membrane Barrier: Structure, Targets, and Antimicrobial Strategies for Gram\u2010Negative Bacteria","volume":"17","author":"Xu F.","year":"2026","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_11_73_1","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.701022","article-title":"Aspergillus niger as a Secondary Metabolite Factory","volume":"9","author":"Yu R.","year":"2021","journal-title":"Frontiers in Chemistry"},{"issue":"10","key":"e_1_2_11_74_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3390\/biology10100961","article-title":"Bioprospecting Desert Plants for Endophytic and Biostimulant Microbes: A Strategy for Enhancing Agricultural Production in a Hotter, Drier Future","volume":"10","author":"Zhang Q.","year":"2021","journal-title":"Biology"},{"issue":"1","key":"e_1_2_11_75_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-18565-y","article-title":"Honeybee Associated Aspergillus niger AW17 as a Source of Selective Anticancer Compounds With Cytotoxicity Evaluation in Human Cancer Cell Lines","volume":"15","author":"Zina H. A.","year":"2025","journal-title":"Scientific Reports"}],"container-title":["MicrobiologyOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mbo3.70430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mbo3.70430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mbo3.70430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:00:25Z","timestamp":1791439225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mbo3.70430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mbo3.70430"],"URL":"https:\/\/doi.org\/10.1002\/mbo3.70430","archive":["Portico"],"relation":{},"ISSN":["2045-8827","2045-8827"],"issn-type":[{"value":"2045-8827","type":"print"},{"value":"2045-8827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70430"}}