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This study aimed to molecularly identify hvKP isolates screened for coexisting virulence determinants and evaluate the association between specific virulence genes and hypervirulence. Clinical specimens were collected from hospitalized patients, and\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    isolates were identified phenotypically using microscopic culture characteristics and biochemical assays and genotypically confirmed by PCR targeting the\n                    <jats:italic>khe<\/jats:italic>\n                    gene. Hypermucoviscosity regulators\n                    <jats:sub>p<\/jats:sub>\n                    <jats:italic>rm<\/jats:italic>\n                    pA and\n                    <jats:sub>p<\/jats:sub>\n                    <jats:italic>rmp<\/jats:italic>\n                    A2, siderophore\u2010encoding genes\n                    <jats:italic>iuc<\/jats:italic>\n                    A and\n                    <jats:italic>iro<\/jats:italic>\n                    N, and other virulence\u2010associated genes including\n                    <jats:italic>wzi<\/jats:italic>\n                    ,\n                    <jats:italic>mag<\/jats:italic>\n                    A,\n                    <jats:italic>wzy<\/jats:italic>\n                    K2,\n                    <jats:italic>wab<\/jats:italic>\n                    G, and\n                    <jats:italic>peg\u2010<\/jats:italic>\n                    344 were investigated. Eighty\u2010two capsulated non\u2010motile\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    isolates were confirmed with\n                    <jats:sub>p<\/jats:sub>\n                    <jats:italic>rm<\/jats:italic>\n                    pA and\n                    <jats:sub>p<\/jats:sub>\n                    <jats:italic>rmp<\/jats:italic>\n                    A2 detected in 42 and 29 isolates, respectively, whereas\n                    <jats:italic>iuc<\/jats:italic>\n                    A was identified in 31 isolates and\n                    <jats:italic>iro<\/jats:italic>\n                    N in 6 isolates only. Based on the molecular criteria, 34 isolates were classified as hvKP and 48 as classical\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    (cKP). A strong association was observed between the\n                    <jats:italic>peg\u2010<\/jats:italic>\n                    344 gene and hypervirulence (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0001), whereas hypermucoviscosity showed a weaker correlation. However, low\u2010speed sedimentation assay (LSSA) analysis demonstrated a significant relationship between the hypermucoviscous phenotype and genotypic hypervirulence (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.041). These findings highlight the molecular determinants of hvKP and identify\n                    <jats:italic>peg<\/jats:italic>\n                    \u2010344 as the gene most strongly associated with hypervirulence; however, its moderate sensitivity (58.8%) and absence in over 40% of hvKP isolates indicate that it is better suited as a supportive confirmatory marker than a standalone diagnostic biomarker for hvKP\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70433","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:46:07Z","timestamp":1791999967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Insights Into Hypervirulent\n                    <i>Klebsiella pneumoniae<\/i>\n                    : Identification and Correlation of Virulence Determinant"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-2556","authenticated-orcid":false,"given":"Fathy M.","family":"Elkady","sequence":"first","affiliation":[{"name":"Microbiology and Immunology Department Faculty of Pharmacy (Boys) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosiba S.","family":"Basher","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0102-3637","authenticated-orcid":false,"given":"Mohammed S.","family":"Abdulrahman","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology Department Faculty of Pharmacy (Boys) Al\u2010Azhar University Cairo Egypt"},{"name":"Department of Microbiology and Immunology Faculty of Pharmacy Menoufia National University Menoufi Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0024-3606","authenticated-orcid":false,"given":"Amr H.","family":"Hashem","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology Faculty of Science Al\u2013Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9612-0850","authenticated-orcid":false,"given":"Rafik Abdellatif","family":"Metwally","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Faculty of Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abdel","family":"Tawab","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Medicine Al\u2013Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-7912","authenticated-orcid":false,"given":"Ebrahim","family":"Saied","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology Faculty of Science Al\u2013Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasir A.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-4530","authenticated-orcid":false,"given":"Mohammed","family":"Aufy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diagmicrobio.2020.115139","article-title":"Molecular Strain Typing of Multidrug\u2010Resistant Klebsiella pneumoniae: Capsular Wzi Gene Sequencing Versus Multiple Locus Variable Number Tandem Repeat Analysis","volume":"98","author":"Aboulela A.","year":"2020","journal-title":"Diagnostic Microbiology and Infectious Disease"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3390\/microorganisms11030661","article-title":"Antimicrobial Resistance Pattern, Pathogenicity and Molecular Properties of Hypervirulent Klebsiella pneumonia (hvKp) Among Hospital\u2010Acquired Infections in the Intensive Care Unit (ICU)","volume":"11","author":"Alharbi M. 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