{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:13:12Z","timestamp":1772982792750,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cryptococcal infection is a major cause of opportunistic infection in HIV\/AID\u2010infected peoples. We determined cryptococcal antigenemia and cryptococcal meningitis among antiretroviral therapy (ART) initiated and ART\u2010naive HIV\u2010infected peoples. A cross\u2010sectional study was conducted at selected health facilities in Mekelle, Ethiopia. Blood was collected to determine CD4 and plasma cryptococcal antigen (CrAg). CSF CrAg and CSF culture and urease tests were also done. Socio\u2010demographic and clinical data were collected using a structured questionnaire and clinical chart review. From the enrolled study participants, 267 study participants had complete data, of which, 137 (51%) were females. From the study participants, 140 (52%) and 127 (48%) were ART experienced and ART na\u00efve, respectively. The prevalence of cryptococcal antigenemia was 9 (3.4%). All the study participants, except one (CD4\u00a0=\u00a0120\u00a0cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    ), had CD4 count less than 100\u00a0cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    . From CrAg\u2010positive peoples, 6 (4.7%) were ART na\u00efve. Five CrAg\u2010positive peoples had cryptococcal meningitis. Being male, rural residence, and being hospitalized were associated with cryptococcal antigenemia. Cryptococcal infection poses a substantial risk of HIV\u2010positive peoples. This study provides relevant data for CrAg screening interventions in patients with low CD4 cell counts.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.746","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T07:09:21Z","timestamp":1538464161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cryptococcal antigenemia and associated risk factors among ART\u2010na\u00efve and ART\u2010experienced HIV\u2010infected peoples at selected health institutions of Mekelle, Northern Ethiopia"],"prefix":"10.1002","volume":"8","author":[{"given":"Kibra","family":"Hailu","sequence":"first","affiliation":[{"name":"Laboratory Department Ayder Comprehensive Specialized Hospital Mekelle Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4732-9546","authenticated-orcid":false,"given":"Selam","family":"Niguse","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Immunology Unit College of Health Sciences, Mekelle University Mekelle Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiflom","family":"Hagos","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Immunology Unit College of Health Sciences, Mekelle University Mekelle Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmud","family":"Abdulkader","sequence":"additional","affiliation":[{"name":"Medical Microbiology and Immunology Unit College of Health Sciences, Mekelle University Mekelle Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058377"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122583"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.153231"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-9-11"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075585"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix613"},{"issue":"27","key":"e_1_2_10_8_1","first-page":"585","article-title":"Prevalence and correlates of cryptococcal antigen positivity among the AIDS patients\u2010United States, 1986\u20132012","volume":"63","author":"Centers for disease control and Prevention (CDC)","year":"2014","journal-title":"MMWR. 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