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In the present study, we describe the antibacterial activity of new synthetic 1,3\u2010bis(aryloxy)propan\u20102\u2010amines against Gram\u2010positive pathogens (<jats:italic>Streptococcus pyogenes<\/jats:italic>,<jats:italic> Enterococcus faecalis<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic>) including Methicillin\u2013resistant <jats:italic>S.\u00a0aureus<\/jats:italic> strains. Our compounds showed minimal inhibitory concentrations (MIC) in the range of 2.5\u201310\u00a0\u03bcg\/ml (5.99\u201328.58\u00a0\u03bcM), against different bacterial strains. The minimal bactericidal concentrations found were similar to MIC, suggesting a bactericidal mechanism of action of these compounds. Furthermore, possible molecular targets were suggested by chemical similarity search followed by docking approaches. Our compounds are similar to known ligands targeting the cell division protein <jats:italic>FtsZ<\/jats:italic>, Quinolone resistance protein <jats:italic>norA<\/jats:italic> and the Enoyl\u2010[acyl\u2010carrier\u2010protein] reductase <jats:italic>FabI<\/jats:italic>. Taken together, our data show that synthetic 1,3\u2010bis(aryloxy)propan\u20102\u2010amines are active against Gram\u2010positive bacteria, including multidrug\u2013resistant strains and can be a promising lead in the development of new antibacterial compounds for the treatment of these infections.<\/jats:p>","DOI":"10.1002\/mbo3.814","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T03:54:06Z","timestamp":1550462046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Antibacterial activity of synthetic 1,3\u2010bis(aryloxy)propan\u20102\u2010amines against Gram\u2010positive bacteria"],"prefix":"10.1002","volume":"8","author":[{"given":"Mateus S. M.","family":"Serafim","sequence":"first","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stef\u00e2nia N.","family":"Lavorato","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thales","family":"Kronenberger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine VIII University Hospital T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamara V.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziele P.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone G.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erna G.","family":"Kroon","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius G.","family":"Maltarollo","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo J.","family":"Alves","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno E. 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