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Here, we used the water avoidance stress (WAS) test in mouse models for chronic stress\u2010induced gastritis to investigate the underlying mechanisms of this disease. The effect of stress on the gastric microbiota was analyzed based on 16S rRNA sequencing; the changes in hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) and inflammatory cytokine levels in gastric tissues were detected by Western blotting, ELISA, immunofluorescence, and qRT\u2010PCR. Hematoxylin and eosin staining was used as an indicator of the gastritis histological score. This finding is consistent with previous studies showing that gastric H<jats:sub>2<\/jats:sub>S is negatively associated with the inflammatory index and might protect the gastrointestinal tract from inflammation. WAS\u2010induced gastritis was associated with a reduction in H<jats:sub>2<\/jats:sub>S release, which appeared to affect the homeostasis of the gastric microbiota of mice. Inflammation and microbial dysbiosis were partially reversed by sodium hydrosulfide (NaHS) and vitamin B6 (VB6) supplementation, suggesting the therapeutic potential of VB6 supplementation for the treatment of stress\u2010induced gastritis. Gastritis has a serious impact on health and quality of life. An increasing number of people are suffering from chronic gastritis linked to a high\u2010stress lifestyle, and our research provides clues for the prevention and treatment of stress\u2010induced gastritis.<\/jats:p>","DOI":"10.1002\/mbo3.951","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T01:41:40Z","timestamp":1571794900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hydrogen sulfide\u2010mediated resistance against water avoidance stress\u2010induced gastritis by maintenance of gastric microbial homeostasis"],"prefix":"10.1002","volume":"9","author":[{"given":"Yingnan","family":"Han","sequence":"first","affiliation":[{"name":"Department of Microbiology Key Laboratory for Experimental Teratology of Ministry of Education Key Laboratory of Infection and Immunology of Shandong Province School of Basic Medicine Shandong University Jinan China"},{"name":"Shandong Center 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