{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:20:34Z","timestamp":1790518834732,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Candida albicans<\/jats:italic> is an opportunist pathogen responsible for a large spectrum of infections, from superficial mycosis to systemic diseases known as candidiasis. Its ability to grow in different morphological forms, such as yeasts or filamentous hyphae, contributes to its survival in diverse microenvironments. Iron uptake has been associated with virulence, and <jats:italic>C. albicans<\/jats:italic> has developed elaborate strategies for acquiring iron from its host. In this work, we analyze the metabolic changes in response to changes in iron content in the growth medium and compare <jats:italic>C. albicans<\/jats:italic> adaptation to the presence or absence of iron. Functional and morphological studies, correlated to a quantitative proteomic analysis, were performed to assess the specific pathways underlying the response to iron, both in the yeast and filamentous forms. Overall, the results show that the adaptive response to iron is associated with a metabolic remodeling affecting the energetic pathways of the pathogen. This includes changes in the thiol\u2010dependent redox status, the activity of key mitochondrial enzymes and the respiratory chain. Iron deficiency stimulates bioenergetic pathways, whereas iron\u2010rich condition is associated with greater biosynthetic needs, particularly in filamentous forms. Moreover, we found that <jats:italic>C. albicans<\/jats:italic> yeast cells have an extraordinary capability to adapt to changes in environmental conditions.<\/jats:p>","DOI":"10.1002\/mbo3.970","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T19:20:56Z","timestamp":1575314456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The adaptive response to iron involves changes in energetic strategies in the pathogen <i>Candida albicans<\/i>"],"prefix":"10.1002","volume":"9","author":[{"given":"Celia","family":"Duval","sequence":"first","affiliation":[{"name":"Laboratoire Mitochondries M\u00e9taux et Stress Oxydant Institut Jacques Monod UMR 7592 Universit\u00e9 Paris\u2010Diderot\/CNRS (USPC) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Macabiou","sequence":"additional","affiliation":[{"name":"Laboratoire Mitochondries M\u00e9taux et Stress Oxydant Institut Jacques Monod UMR 7592 Universit\u00e9 Paris\u2010Diderot\/CNRS (USPC) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Garcia","sequence":"additional","affiliation":[{"name":"Plateforme Prot\u00e9omique structurale et fonctionnelle\/Spectrom\u00e9trie de masse Institut Jacques Monod UMR 7592 Universit\u00e9 Paris\u2010Diderot\/CNRS (USPC) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Lesuisse","sequence":"additional","affiliation":[{"name":"Laboratoire Mitochondries M\u00e9taux et Stress Oxydant Institut Jacques Monod UMR 7592 Universit\u00e9 Paris\u2010Diderot\/CNRS (USPC) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8549-2707","authenticated-orcid":false,"given":"Jean\u2010Michel","family":"Camadro","sequence":"additional","affiliation":[{"name":"Laboratoire Mitochondries M\u00e9taux et Stress Oxydant Institut Jacques Monod UMR 7592 Universit\u00e9 Paris\u2010Diderot\/CNRS (USPC) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-7034","authenticated-orcid":false,"given":"Fran\u00e7oise","family":"Auch\u00e8re","sequence":"additional","affiliation":[{"name":"Laboratoire Mitochondries M\u00e9taux et Stress Oxydant Institut Jacques Monod UMR 7592 Universit\u00e9 Paris\u2010Diderot\/CNRS (USPC) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp430"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000217"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00570.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00055-X"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn178"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.117.300224"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00108-08"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.10.007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.08.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46386-0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.11.003"},{"key":"e_1_2_11_13_1","volume-title":"Candida and candidiasis","author":"Calderone R. 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