{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T20:10:15Z","timestamp":1700251815323},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,10,23]],"date-time":"2003-10-23T00:00:00Z","timestamp":1066867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Karyotype and comparative genomic hybridization (CGH) analyses were performed to identify nonrandom\/consistent chromosomal alterations in solely estrogen (E)\u2010induced primary ectopic uterine\u2010like stem cell tumors in the kidney (EULTK) of the Syrian hamster, using a criterion of \u226520% frequency for nonrandom occurrence. Employing this criterion, EULTK karyotype analysis showed consistent gains in chromosomes 3, 6, 11, 14, 16, 20, and 21. Consistent trisomies were seen in all of these nonrandomly gained chromosomes. Only chromosomes 3 and 6 exhibited appreciable tetrasomies. Chromosome losses were observed consistently in chromosomes 7, 12, 17, and 19. Employing the same criterion, CGH analysis of primary EULTKs showed nonrandom amplified sequences at <jats:italic>1pa1\u2013a4<\/jats:italic>, <jats:italic>2cen\u2013pter<\/jats:italic>, <jats:italic>3pa1\u2013a4<\/jats:italic>, <jats:italic>6qb2\u2013b4<\/jats:italic>, <jats:italic>20qa1\u2013a4<\/jats:italic>, <jats:italic>21qa1\u2013a2<\/jats:italic>, <jats:italic>Xqa3\u2013qter<\/jats:italic> and regional consistent losses at <jats:italic>1qc1\u2010qter<\/jats:italic>, <jats:italic>2qb1\u2013c1<\/jats:italic>, <jats:italic>3qa2\u2013a7<\/jats:italic>, <jats:italic>11qb5\u2010qter<\/jats:italic>, <jats:italic>15qa2\u2013a5<\/jats:italic>, <jats:italic>18qa2\u2013a4<\/jats:italic>, and <jats:italic>21pa<\/jats:italic>. Moreover, 88% of the EULTKs examined exhibited amplification of the <jats:italic>6qb2\u2013b4<\/jats:italic> region, where c\u2010<jats:italic>myc<\/jats:italic> resides. The data presented lend credence to the supposition that chromosomal instability (CIN) is elicited by the upstream overexpression and subsequent amplification of c\u2010<jats:italic>myc<\/jats:italic> by Es in multipotential interstitial uterine stem cells present in the kidney, thus leading to neoplastic development. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.10149","type":"journal-article","created":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T08:01:51Z","timestamp":1067241711000},"page":"97-105","source":"Crossref","is-referenced-by-count":9,"title":["Comparative genomic hybridization of estrogen\u2010induced ectopic uterine\u2010like stem cell neoplasms in the hamster kidney: Nonrandom chromosomal alterations"],"prefix":"10.1002","volume":"38","author":[{"given":"Dan","family":"Papa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Antonia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,23]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-11-4-524"},{"key":"e_1_2_7_3_2","first-page":"1020","article-title":"Morphological and immunohistochemical studies of the estrogen\u2010induced Syrian hamster renal tumor: Probable cell of origin","volume":"49","author":"Gonzalez A","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_7_4_2","first-page":"1922","article-title":"Characterization of early lesions in estrogen\u2010induced renal tumors in the Syrian hamster","volume":"51","author":"Oberley Td","year":"1991","journal-title":"Cancer 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