{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:34Z","timestamp":1786978234900,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,7]],"date-time":"2005-03-07T00:00:00Z","timestamp":1110153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    DNA repair enzyme genetic polymorphisms have been postulated to increase the risk of certain cancers in the presence of tobacco carcinogen exposures. The XPD protein is an important component of the TFIIH transcription factor complex.\n                    <jats:italic>XPD<\/jats:italic>\n                    genetic polymorphisms resulting in amino acids substitutions may lead to alterations in TFIIH helicase activity, resulting in repair and transcription defects. Cyclin D1 is a key regulatory protein for the transition of cells from the G\n                    <jats:sub>1<\/jats:sub>\n                    \u2010S cell cycle phase. The\n                    <jats:italic>CCND1<\/jats:italic>\n                    G870A polymorphism has been reported to enhance alternate splicing of a stable mRNA variant, which may result in the bypass of the G\n                    <jats:sub>1<\/jats:sub>\n                    \/S cell cycle checkpoint. In this study,\n                    <jats:italic>XPD<\/jats:italic>\n                    G23591A (Asp312Asn) and A35931C (Lys751Gln) polymorphisms and the\n                    <jats:italic>CCND1<\/jats:italic>\n                    G870A splice variant frequencies were determined in 273 upper aero\u2010digestive tract cancer cases and 269 controls. The\n                    <jats:italic>XPD<\/jats:italic>\n                    Asp312Asn variant frequency was significantly different among cases and controls and conferred an odds ratio (OR) of 1.3 (95% CI 1.0\u20131.8). However, individuals with the\n                    <jats:italic>CCND1<\/jats:italic>\n                    G870A and\n                    <jats:italic>XPD<\/jats:italic>\n                    Lys751Gln variants had higher age adjusted ORs of 3.2 (95% CI 2.2\u20134.6) and 2.2 (95% CI 1.5\u20133.2), respectively. Furthermore, a significant gene\u2013gene interaction was observed among cases with at least two variant alleles for both\n                    <jats:italic>CCND1<\/jats:italic>\n                    and\n                    <jats:italic>XPD<\/jats:italic>\n                    genes [OR 7.09 (95% CI 4.03\u201312.5)]. Smokers with a combination of at least one variant allele of both\n                    <jats:italic>CCND1<\/jats:italic>\n                    and\n                    <jats:italic>XPD<\/jats:italic>\n                    genes also had an elevated risk as compared to nonsmokers. This is the first study to suggest an associative interaction between\n                    <jats:italic>XPD<\/jats:italic>\n                    and\n                    <jats:italic>CCND1<\/jats:italic>\n                    genetic polymorphisms, tobacco exposure, and cancer risk. \u00a9 2005 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/mc.20086","type":"journal-article","created":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T01:00:54Z","timestamp":1110243654000},"page":"222-228","source":"Crossref","is-referenced-by-count":27,"title":["Association of polymorphisms in the\n                    <i>cyclin D1<\/i>\n                    and\n                    <i>XPD<\/i>\n                    genes and susceptibility to cancers of the upper aero\u2010digestive tract"],"prefix":"10.1002","volume":"42","author":[{"given":"Shama","family":"Buch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Autumn","family":"Gaither Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Odom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M.","family":"Siegfried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer R.","family":"Grandis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Romkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.49.1.33"},{"key":"e_1_2_6_3_2","first-page":"1513","article-title":"Polymorphisms in DNA repair genes and associations with cancer risk","volume":"11","author":"Goode E","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/17.6.463"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.4.593"},{"key":"e_1_2_6_6_2","first-page":"1377","article-title":"Gene\u2010environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancer","volume":"62","author":"Zhou W","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.12.2219"},{"key":"e_1_2_6_8_2","unstructured":"David\u2010BeabesG LunnR LondonS.No association between the XPD (Lys751Gln) polymorphism or the XRCC3 (Thr241Met) polymorphism and lung cancer risk. Cancer Epidemiol Biomarkers Prev2001;10:911\u2013912."},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.4.599"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(01)00447-0"},{"key":"e_1_2_6_11_2","first-page":"1354","article-title":"Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients","volume":"61","author":"Spitz M","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_12_2","first-page":"1005","article-title":"Alternate splicing produces a novel cyclin D1 transcript","volume":"11","author":"Betticher D","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_6_13_2","first-page":"815","article-title":"Cyclin D1, glutathione S\u2010transferase, and cytochrome P450 genotypes and outcome in Patients with upper aerodigestive tract cancers: Assessment of the importance of individual genes using multivariate analysis","volume":"8","author":"Matthias C","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63038-6"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.3.198"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00131.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.8.1195"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh075"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.9.1084"},{"key":"e_1_2_6_20_2","first-page":"2411","article-title":"Polymorphism within the cyclin D1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck","volume":"4","author":"Matthias C","year":"1998","journal-title":"Clin Cancer Res"},{"key":"e_1_2_6_21_2","first-page":"176","article-title":"Lack of association between CCND1 G870A polymorphism and risk for esophageal squamous cell carcinoma","volume":"12","author":"Yu C","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.21.2843"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.20086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.20086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T21:33:19Z","timestamp":1697578399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.20086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1002\/mc.20086"],"URL":"https:\/\/doi.org\/10.1002\/mc.20086","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,7]]}}}