{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:33:55Z","timestamp":1787967235133,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T00:00:00Z","timestamp":1112659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cux\u20101 is a member of a family of homeobox genes structurally related to Drosophila Cut. Mammalian Cut proteins function as transcriptional repressors of genes specifying terminal differentiation in multiple cell lineages. In addition, mammalian Cut proteins serve as cell\u2010cycle\u2010dependent transcriptional factors in proliferating cells, where they function to repress expression of the cyclin kinase inhibitors p21 and p27. Previously we showed that transgenic mice expressing Cux\u20101 under control of the CMV immediate early gene promoter develop multiorgan hyperplasia. Here we show that mice constitutively expressing Cux\u20101 exhibit hepatomegaly correlating with an increase in cell proliferation. In addition, the increase in Cux\u20101 expression in transgenic livers was associated with a decrease in p21, but not p27, expression. Within transgenic livers, Cux\u20101 was ectopically expressed in a population of small cells, but not in mature hepatocytes, and many of these small cells expressed markers of proliferation. Transgenic livers showed an increase in \u03b1\u2010smooth muscle actin, indicating activation of hepatic stellate cells, and an increase in cells expressing chromogranin\u2010A, a marker for hepatocyte precursor cells. Morphological analysis of transgenic livers revealed inflammation, hepatocyte swelling, mixed cell foci, and biliary cell hyperplasia. These results suggest that increased expression of Cux\u20101 may play a role in the activation of hepatic stem cells, possibly through the repression of the cyclin kinase inhibitor p21. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.20091","type":"journal-article","created":{"date-parts":[[2005,4,6]],"date-time":"2005-04-06T13:19:27Z","timestamp":1112793567000},"page":"18-30","source":"Crossref","is-referenced-by-count":24,"title":["Hepatomegaly in transgenic mice expressing the homeobox gene <i>Cux\u20101<\/i>"],"prefix":"10.1002","volume":"43","author":[{"given":"Gregory B.","family":"Vanden Heuvel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer G.","family":"Brantley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal 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