{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:56:39Z","timestamp":1792151799992,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T00:00:00Z","timestamp":1149033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidemiologic investigations demonstrated that arsenite exposure increases the risk of various human cancers, including skin, lung, bladder, and kidney cancers. However, oral administration of arsenite alone has failed to induce tumors in animal models, suggesting that arsenic may act to enhance mutagenicity induced by other carcinogens. Arsenite may function as a co\u2010carcinogen, acting by inhibiting repair of carcinogen\u2010induced DNA damage mediated by p53 and <jats:italic>p21<\/jats:italic>, a p53 target gene. To elucidate the interaction between arsenite and p53 tumor suppressor protein, we studied the effect of arsenite on ultraviolet B (UVB)\u2010induced p53 phosphorylation, p53 DNA binding activity, and p53\u2010induced target gene transactivation in the JB6 Cl41 mouse epidermal skin cell model. Our results indicated that arsenite suppressed UVB\u2010induced p53 phosphorylation and p53 DNA binding activity. Arsenite also inhibited casein kinase 2 (CK2) activity and decreased p53\u2010regulated p21 protein expression. These data suggest that the direct inhibition of p53 functional activation is one of the mechanisms through which arsenite interferes with p53 function, and thus may be a significant mechanism for the co\u2010carcinogenic effects of arsenite. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.20245","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T20:53:10Z","timestamp":1149108790000},"page":"861-870","source":"Crossref","is-referenced-by-count":18,"title":["Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene <i>p21<\/i> expression in mouse epidermal JB6 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