{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:46:41Z","timestamp":1743961601745},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T00:00:00Z","timestamp":1178150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In contrast to sunlight\u2010induced squamous cell carcinoma the etiology of cutaneous malignant melanoma (CMM) is not well understood. In particular, the role that sunlight exposure and DNA damage play in the initiation of this deadly form of cancer is an open question. Early UV carcinogenesis studies in the <jats:italic>Xiphophorus<\/jats:italic> backcross hybrid fish model by Richard Setlow indicated that direct DNA damage caused by exposure to the UVB component of sunlight is necessary and sufficient for melanoma formation. Subsequent studies by Setlow suggested that monochromatic UVA radiation that is not directly absorbed by DNA was also sufficient for melanoma induction in <jats:italic>Xiphophorus<\/jats:italic> and was, indeed, primarily responsible for initiating human melanoma. These results had significant public health consequences, suggesting that although sunscreens may inhibit UVB\u2010induced erythema they may actually increase exposure to the UVA wavelengths that cause cancer. An intensive worldwide public debate on sunscreen use and \u201cabuse\u201d ensued. Our data do not support a major role of free radical chemistry in melanoma induction. We find evidence that the direct damage caused by the absorption of UVB wavelengths by DNA (e.g., the cyclobutane pyrimidine dimer or CPD) is required for CMM formation and that the ability to repair these lesions plays a significant role in tumor susceptibility. Using the <jats:italic>Xiphophorus<\/jats:italic> backcross hybrid fish we are currently in the process of re\u2010evaluating the wavelength\u2010 and DNA damage\u2010dependence of UV\u2010induced melanoma and the role nucleotide excision repair and the genes controlling DNA repair and the UV response play in melanoma resistance. From these studies we hope to define the effective solar wavelength boundaries of melanoma, identify the class of critical DNA damage and elucidate the role of DNA repair in tumor suppression. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.20341","type":"journal-article","created":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T17:37:49Z","timestamp":1178213869000},"page":"679-684","source":"Crossref","is-referenced-by-count":21,"title":["The etiology of sunlight\u2010induced melanoma in <i>Xiphophorus<\/i> hybrid fish"],"prefix":"10.1002","volume":"46","author":[{"given":"David","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Paniker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Trono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney","family":"Nairn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107183250306"},{"key":"e_1_2_7_3_2","first-page":"53","article-title":"Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice","volume":"53","author":"de Gruijl FR","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/php.1990.51.6.765"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199404000-00001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59410-6_15"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05420.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203030-00005"},{"key":"e_1_2_7_9_2","volume-title":"Cancer Medicine","author":"Cleaver JE","year":"2003"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.14.6666"},{"key":"e_1_2_7_11_2","first-page":"1","volume-title":"Bioorganic photochemistry: Photochemistry and the nucleic acids","author":"Cadet J","year":"1990"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1989.tb05578.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi034593c"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg402"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01408"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.65.070196.000355"},{"key":"e_1_2_7_17_2","first-page":"46","article-title":"Use of platyfishes and swordtails in biological research","volume":"31","author":"Kazianis S","year":"2002","journal-title":"Lab Anim (NY)"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02142235"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(94)90310-7"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.6.2350"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2000)0710743TMMMIR2.0.CO2"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2001)0730020DRFURA2.0.CO2"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.20341","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.20341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T08:33:39Z","timestamp":1694594019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.20341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,3]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/mc.20341"],"URL":"https:\/\/doi.org\/10.1002\/mc.20341","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,3]]}}}