{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:24:51Z","timestamp":1782523491125,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,12,4]],"date-time":"2008-12-04T00:00:00Z","timestamp":1228348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin 2 (IL2) is a typical Th1 cytokine, and interleukin 4 (IL4) is an inducible Th2 cytokine. These cytokines are critical mediators of the Th1\/Th2 balance and apoptosis potential and involved in the process of inflammation\u2010mediated carcinogenesis in human organs, including the gastrointestinal tract. Therefore, we tested the hypothesis that functional variants in IL2 and IL4 were associated with risk of gastric cancer by genotyping two promoter polymorphisms in IL2 G\u2010330T (rs2069762) and IL4 T\u2010168C (rs2070874) in a case\u2010control study of 1045 patients with incident gastric cancer and 1100 cancer\u2010free controls in a high\u2010risk Han Chinese population. We found that, compared with the IL4 \u2010168TT genotype, heterozygous \u2010168TC and combined \u2010168TC\/CC genotypes were associated with a significantly decreased gastric cancer risk [adjusted odds ratio (OR)\u2009=\u20090.81, 95% confidence interval (CI)\u2009=\u20090.67\u20130.98 for \u2010168TC; OR\u2009=\u20090.83, 95% CI\u2009=\u20090.69\u20131.00 for \u2010168TC\/CC, respectively]. Furthermore, this significant protective effect was more evident for gastric cardia cancer patients (adjusted OR\u2009=\u20090.73, 95% CI\u2009=\u20090.56\u20130.95 for \u2010168TC\/CC vs. \u2010168TT). For IL2 G\u2010330T, subjects carrying GT\/TT genotypes also had a significantly reduced risk of gastric cardia cancer (adjusted OR\u2009=\u20090.68, 95% CI\u2009=\u20090.46\u20130.99), compared with those carrying the GG genotype. Our results indicate that IL4 T\u2010168C and IL2 G\u2010330T promoter polymorphisms may contribute to the etiology of gastric cardia cancer in Chinese populations. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.20502","type":"journal-article","created":{"date-parts":[[2008,12,4]],"date-time":"2008-12-04T19:54:42Z","timestamp":1228420482000},"page":"626-632","source":"Crossref","is-referenced-by-count":48,"title":["Promoter polymorphisms of IL2, IL4, and risk of gastric cancer in a high\u2010risk Chinese population"],"prefix":"10.1002","volume":"48","author":[{"given":"Juan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010bing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010bin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010gang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010lai","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010qian","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010chu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010bing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,4]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2004.029330"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.6.F23"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc703"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0889-8553(21)00265-X","article-title":"Helicobacter 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