{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:18:46Z","timestamp":1790403526480,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T00:00:00Z","timestamp":1251676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T00:00:00Z","timestamp":1251676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Carcinog."],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1002\/mc.20578","type":"journal-article","created":{"date-parts":[[2009,8,31]],"date-time":"2009-08-31T14:14:28Z","timestamp":1251728068000},"page":"68-74","source":"Crossref","is-referenced-by-count":21,"title":["<i>N<\/i>-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway"],"prefix":"10.1002","volume":"49","author":[{"given":"Dongyin","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonghou","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,8,31]]},"reference":[{"key":"10.1002\/mc.20578-BIB1|cit1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0925-4439(96)00032-4","article-title":"Curcuminan antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells","volume":"1317","author":"Kuo","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/mc.20578-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1093\/carcin\/bgl009","article-title":"Dihydroxyphenylethanol induces apoptosis by activating serine\/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells","volume":"27","author":"Guichard","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1002\/mc.20578-BIB3|cit3","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.4049\/jimmunol.178.Supp.49.25","article-title":"Vitamin C induces apoptosis in human colon cancer cells through endoplasmic reticulum stress and mitochondrial pathway","volume":"178","author":"Kim","year":"2007","journal-title":"J Immunol"},{"key":"10.1002\/mc.20578-BIB4|cit4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0149-2918(00)88479-9","article-title":"Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: A meta-analysis of published double-blind, placebo-controlled clinical trials","volume":"22","author":"Grandjean","year":"2000","journal-title":"Clin Ther"},{"key":"10.1002\/mc.20578-BIB5|cit5","first-page":"744","article-title":"The interactions of penicillamine with copper in vivo and the effect on hepatic metallothionein levels and copper\/zinc distribution: The implications for Wilson's disease and arthritis therapy","volume":"119","author":"McQuaid","year":"1992","journal-title":"J Lab Clin Med"},{"key":"10.1002\/mc.20578-BIB6|cit6","first-page":"1723","article-title":"Antioxidant action via p53-mediated apoptosis","volume":"58","author":"Liu","year":"1998","journal-title":"Cancer Res"},{"key":"10.1002\/mc.20578-BIB7|cit7","first-page":"1443","article-title":"Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine","volume":"62","author":"Havre","year":"2002","journal-title":"Cancer Res"},{"key":"10.1002\/mc.20578-BIB8|cit8","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0002-9440(10)63727-3","article-title":"N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer","volume":"164","author":"Agarwal","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1002\/mc.20578-BIB9|cit9","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1172\/JCI26373","article-title":"Endoplasmic reticulum stress: Cell life and death decisions","volume":"115","author":"Xu","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1002\/mc.20578-BIB10|cit10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1385\/MB:34:2:279","article-title":"The unfolded protein response","volume":"34","author":"Schroder","year":"2006","journal-title":"Mol Biotechnol"},{"key":"10.1002\/mc.20578-BIB11|cit11","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep"},{"key":"10.1002\/mc.20578-BIB12|cit12","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1158\/0008-5472.CAN-06-1794","article-title":"Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells","volume":"67","author":"Little","year":"2007","journal-title":"Cancer Res"},{"key":"10.1002\/mc.20578-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/jcb.21693","article-title":"Involvement of the role of Chk1 in lithium-induced G2\/M phase cell cycle arrest in hepatocellular carcinoma cells","volume":"104","author":"Wang","year":"2008","journal-title":"J Cell Biochem"},{"key":"10.1002\/mc.20578-BIB14|cit14","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1074\/jbc.271.7.3667","article-title":"Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells","volume":"271","author":"Tsai","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1002\/mc.20578-BIB15|cit15","doi-asserted-by":"crossref","first-page":"50455","DOI":"10.1074\/jbc.M406749200","article-title":"N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts","volume":"279","author":"Qanungo","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1002\/mc.20578-BIB16|cit16","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/carcin\/20.9.1869","article-title":"Induction of cyclin-dependent kinase inhibitors and G(1) prolongation by the chemopreventive agent N-acetylcysteine","volume":"20","author":"Liu","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1002\/mc.20578-BIB17|cit17","doi-asserted-by":"crossref","first-page":"21078","DOI":"10.1074\/jbc.M400713200","article-title":"Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction","volume":"279","author":"Thuerauf","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1002\/mc.20578-BIB18|cit18","doi-asserted-by":"crossref","first-page":"6755","DOI":"10.1128\/MCB.20.18.6755-6767.2000","article-title":"ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response","volume":"20","author":"Yoshida","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1002\/mc.20578-BIB19|cit19","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jb\/mvh122","article-title":"Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II","volume":"136","author":"Yamamoto","year":"2004","journal-title":"J Biochem"},{"key":"10.1002\/mc.20578-BIB20|cit20","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1074\/jbc.M311862200","article-title":"Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation","volume":"279","author":"Averous","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1002\/mc.20578-BIB21|cit21","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj20020391","article-title":"Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response","volume":"366","author":"Okada","year":"2002","journal-title":"Biochem J"},{"key":"10.1002\/mc.20578-BIB22|cit22","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1101\/gad.12.7.982","article-title":"CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum","volume":"12","author":"Zinszner","year":"1998","journal-title":"Genes Dev"},{"key":"10.1002\/mc.20578-BIB23|cit23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0014-5793(96)01016-2","article-title":"Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells","volume":"395","author":"Matsumoto","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1002\/mc.20578-BIB24|cit24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1756-8722-1-4","article-title":"Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: Role in cancer prevention and therapy","volume":"1","author":"Selvakumar","year":"2008","journal-title":"J Hematol Oncol"},{"key":"10.1002\/mc.20578-BIB25|cit25","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1073\/pnas.92.8.3264","article-title":"Reconstitution of p53-ubiquitinylation reactions from purified components: The role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)","volume":"92","author":"Rolfe","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/mc.20578-BIB26|cit26","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1128\/JVI.67.6.3111-3117.1993","article-title":"Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53","volume":"67","author":"Hoppe-Seyler","year":"1993","journal-title":"J Virol"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.20578","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.20578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/mc.20578\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T14:57:28Z","timestamp":1685113048000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.20578"}},"subtitle":["NAC AND PEN INDUCE APOPTOSIS"],"short-title":[],"issued":{"date-parts":[[2009,8,31]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"URL":"https:\/\/doi.org\/10.1002\/mc.20578","archive":["Portico"],"relation":{},"ISSN":["0899-1987"],"issn-type":[{"value":"0899-1987","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8,31]]}}}