{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:31:35Z","timestamp":1764700295206},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T00:00:00Z","timestamp":1268611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of gastric antrum adenocarcinoma (GAA) related to <jats:italic>Helicobacter pylori<\/jats:italic> infection. This study, including 361 GAAs and 616 controls without any evidence of tumors, was designed to evaluate the association between the polymorphisms of DNA repair genes <jats:italic>XPC<\/jats:italic> Ala499Val (RS#2228000) and Lys939Gln (RS#2228001), <jats:italic>XPD<\/jats:italic> Lys751Gln (RS#13181), and <jats:italic>XRCC4<\/jats:italic> Ala247Ser (RS#3734091) and Ser298Asn (RS#1805377), and GAA risk for Guangxi population by means of TaqMan\u2010PCR analysis. Increased risks of GAA were found for individuals with <jats:italic>H. pylori<\/jats:italic> positive [odds ratio (OR), 2.48; 95% confidence interval (CI), 1.84\u20133.33] or cagA positive (OR, 7.34; 95% CI, 5.46\u20139.87). No differences were observed among the studied groups with regard to the genotype distribution of <jats:italic>XPC<\/jats:italic> codons 499 and 939 and of <jats:italic>XRCC4<\/jats:italic> codon 247; but <jats:italic>XPD<\/jats:italic> codon 751 genotypes with Gln [ORs (95% CI) were 2.67 (1.98\u20133.58) and 3.97 (2.64\u20135.99) for Lys\/Gln and Gln\/Gln, respectively] and <jats:italic>XRCC4<\/jats:italic> codon 298 genotypes with Asn [ORs (95% CI) were 3.01 (2.21\u20134.10) and 4.78 (3.24\u20137.05) for Ser\/Asn and Asn\/Asn, respectively] increased the risk of GAA. Interestingly, there was an interactive effect between the risk genotypes of these two genes and cagA\u2010positive status in the GAA risk (OR<jats:sub>interact<\/jats:sub>\u2009=\u20092.05 and 2.08, respectively). However, we did not find the gene\u2013<jats:italic>H. pylori<\/jats:italic>\u2010status interaction effects on the risk of GAA (<jats:italic>P<\/jats:italic><jats:sub>interact<\/jats:sub>\u2009&gt;\u20090.05). The results suggested that the polymorphisms of <jats:italic>XPD<\/jats:italic> codon 751 and <jats:italic>XRCC4<\/jats:italic> codon 298 are associated with an increased risk of developing <jats:italic>H. pylori<\/jats:italic>\u2010related GAA among Guangxi population. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.20630","type":"journal-article","created":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T12:47:22Z","timestamp":1268657242000},"page":"611-618","source":"Crossref","is-referenced-by-count":23,"title":["Genetic polymorphisms in DNA repair genes <i>XPC<\/i>, <i>XPD<\/i>, and <i>XRCC4<\/i>, and susceptibility to <i>Helicobacter pylori<\/i> infection\u2010related gastric antrum adenocarcinoma in Guangxi population, China"],"prefix":"10.1002","volume":"49","author":[{"given":"Xi\u2010Dai","family":"Long","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Zhi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu\u2010Xiang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai\u2010Min","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Ping","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Hui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,15]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01823.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05663.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i9.1346"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004230050248"},{"key":"e_1_2_7_6_2","first-page":"327","article-title":"Genetic 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