{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:25:53Z","timestamp":1790486753152,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T00:00:00Z","timestamp":1278028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Grb2\u2010associated binder 1 (Gab1) plays an important role in the regulation of cell growth and transformation. A single nucleotide polymorphism (SNP) (rs3805246) in the Gab1 gene has been suggested to be related to the risk of <jats:italic>Helicobacter pylori<\/jats:italic> infection and chronic atrophic gastritis (CAG) in a study from Japan. We aimed to assess the associations in a population\u2010based study from Germany. In the baseline examination of ESTHER, a population\u2010based study conducted in Saarland, serum pepsinogen I and II and <jats:italic>H. pylori<\/jats:italic> serostatus were measured by ELISA. The Gab1 SNP (rs3805246) was genotyped in 351 serologically defined CAG cases and 351 age\u2010 and sex\u2010matched non\u2010CAG controls. A nonsignificant association was observed between the Gab1 SNP and CAG, with an adjusted odds ratio of 1.15 (0.85\u20131.55) for AA\/AG carriers compared to GG carriers. The magnitude of the association did not change when the analysis was restricted to <jats:italic>H. pylori<\/jats:italic> seropositive subjects. Furthermore, no significant relation was found between the SNP and <jats:italic>H. pylori<\/jats:italic> seropositivity among non\u2010CAG controls. We could not confirm a major association between Gab1 SNP (rs3805246) and the predisposition to <jats:italic>H. pylori<\/jats:italic> infection and CAG in this study population from Germany. Further studies with larger sample size are needed to clarify a potential modest effect of Gab1 genetic polymorphisms. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.20662","type":"journal-article","created":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T21:35:39Z","timestamp":1278452139000},"page":"869-873","source":"Crossref","is-referenced-by-count":3,"title":["Grb2\u2010associated binder 1 (Gab1) genetic polymorphism, <i>Helicobacter pylori<\/i> infection, and chronic atrophic gastritis among older adults from Germany"],"prefix":"10.1002","volume":"49","author":[{"given":"Lei","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie 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