{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:25:23Z","timestamp":1781299523848,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T00:00:00Z","timestamp":1290470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The xeroderma pigmentosum complementation group C (XPC) is responsible for removal of bulky helix\u2010distorting DNA lesions. Several polymorphisms of<jats:italic>XPC<\/jats:italic>gene may modulate the colorectal cancer (CRC) susceptibility. We assessed the association of<jats:italic>XPC<\/jats:italic>Lys939Gln (A\/C), Ala499Val (C\/T), and PAT (\u2212\/+) polymorphisms with CRC risk in a population\u2010based case\u2013control study which included 421 CRC patients and 845 controls. For Lys939Gln, the CC genotype was associated with a significantly increased risk of CRC (odds ratio (OR)\u2009=\u20091.5; 95% confidence interval (CI)\u2009=\u20091.0\u22122.2) compared with the AA genotype. The subjects with PAT +\/+ genotype had a significantly increased risk of CRC (OR\u2009=\u20091.5; 95% CI\u2009=\u20091.0\u22122.3), compared with those with PAT\u2212\/\u2212 genotype. Though no significant association between Ala499Val and CRC risk was observed, we found that individuals carrying the CT\u2009+\u2009TT genotypes showed a significantly decreased risk of rectal cancer (OR\u2009=\u20090.7; 95% CI\u2009=\u20090.5\u22121.0). Additionally, the haplotype C\u2009+\u2009C was associated with a significantly increased CRC risk (OR\u2009=\u20091.3; 95% CI\u2009=\u20091.0\u22121.6), compared with the most common haplotype A\u2010T. Further, individuals with four or more risk alleles exhibited a significantly increased risk of CRC (OR\u2009=\u20091.4; 95% CI\u2009=\u20091.0\u22122.0), with a significant gene\u2010dosage effect (<jats:italic>P<\/jats:italic>for trend\u2009=\u20090.038). Besides, never tea drinking was associated with a significantly increased risk of CRC (OR\u2009=\u20092.3; 95% CI\u2009=\u20091.7\u22123.3). Our results suggest that the<jats:italic>XPC<\/jats:italic>polymorphisms may modulate CRC susceptibility independently or jointly, and tea drinking has a protective effect on CRC. Mol. Carcinog. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.20704","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T14:42:38Z","timestamp":1290523358000},"page":"189-198","source":"Crossref","is-referenced-by-count":26,"title":["The association of<i>XPC<\/i>polymorphisms and tea drinking with colorectal cancer risk in a Chinese 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