{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:34:39Z","timestamp":1791128079391,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,12,28]],"date-time":"2010-12-28T00:00:00Z","timestamp":1293494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ultraviolet (UV) of sunlight is a complete carcinogen that can burn skin, enhance inflammation, and drive skin carcinogenesis. Previously, we have shown that sulforaphane (SFN) inhibited chemically induced skin carcinogenesis via nuclear factor (erythroid\u2010derived 2)\u2010like 2 (Nrf2) and others have shown that broccoli sprout extracts containing high SFN protected against UV\u2010induced skin carcinogenesis in SKH\u20101 hairless mice. A recent study showed that there was no difference between Nrf2 knockout (Nrf2 KO) and Nrf2 wild\u2010type (WT) BALB\/C mice after exposing to high dose of UVB. Since Nrf2 plays critical roles in the anti\u2010oxidative stress\/anti\u2010inflammatory responses, it is relevant to assess the role of Nrf2 for photoprotection against UV. In this context, the role of Nrf2 in UVB\u2010induced skin inflammation in Nrf2 WT and Nrf2 KO C57BL\/6 mice was studied. A single dose of UVB (300\u2009mJ\/cm<jats:sup>2<\/jats:sup>) resulted in skin inflammation in both WT and Nrf2 KO (\u2212\/\u2212) mice (KO mice) at 8\u2009h and 8\u2009d following UVB irradiation. In the WT mice inflammation returned to the basal level to a greater extent when compared to the KO mice. SFN treatment of Nrf2 WT but not Nrf2 KO mice restored the number of sunburn cells back to their basal level by 8\u2009d after UVB irradiation. Additionally, UVB\u2010induced short\u2010term inflammatory biomarkers (interleukin\u20101\u03b2 and interleukin\u20106) were increased in the KO mice and UVB\u2010induced apoptotic cells in the KO mice were significantly higher as compared to that in the WT. Taken together, our results show that functional Nrf2 confers a protective effect against UVB\u2010induced inflammation, sunburn reaction, and SFN\u2010mediated photoprotective effects in the skin. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.20725","type":"journal-article","created":{"date-parts":[[2010,12,28]],"date-time":"2010-12-28T14:29:00Z","timestamp":1293546540000},"page":"479-486","source":"Crossref","is-referenced-by-count":140,"title":["Impact of Nrf2 on UVB\u2010induced skin inflammation\/photoprotection and photoprotective effect of sulforaphane"],"prefix":"10.1002","volume":"50","author":[{"given":"Constance L.","family":"Saw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mou\u2010Tuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin Oo","family":"Khor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan H.","family":"Conney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah\u2010Ng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/372773a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(97)01246-8"},{"key":"e_1_2_6_4_2","first-page":"136","article-title":"Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion","volume":"1","author":"Brash DE","year":"1996","journal-title":"J Invest Dermatol Symp 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