{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:24:12Z","timestamp":1780316652724,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T00:00:00Z","timestamp":1303430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of human urinary bladder cancer increases markedly with age, suggesting a mechanistic connection between aging and bladder carcinogenesis and a potential use of anti\u2010aging agents in bladder cancer chemoprevention. <jats:italic>Rhodiola rosea<\/jats:italic>, growing in high altitude or cold regions of the world, has been reported to have anti\u2010aging effects in <jats:italic>Drosophila<\/jats:italic>. We demonstrated that a <jats:italic>R. rosea<\/jats:italic> extract and one of its bioactive components, salidroside, inhibited the growth of bladder cancer cell lines with a minimal effect on nonmalignant bladder epithelial cells TEU\u20102. Interestingly, the <jats:italic>R. rosea<\/jats:italic> extract and salidroside component exhibited a selective ability to inhibit the growth of p53 knockout primary mouse embryo fibroblasts (p53\u2212\/\u2212 MEFs) compared to their wild\u2010type counterparts. The growth inhibitory effects of the <jats:italic>R. rosea<\/jats:italic> extract and salidroside were, however, attenuated in TSC2 and p53 double knock MEFs (TSC2\u2212\/\u2212, p53\u2212\/\u2212 MEFs), suggesting that TSC2 protein is, at least in part, required for the growth inhibitory effects of the <jats:italic>R. rosea<\/jats:italic> extract and salidroside. The <jats:italic>R. rosea<\/jats:italic> extract and salidroside treatment of UMUC3 cells resulted in an increase of AMP\u2010activated protein kinase (AMPK)\u2010\u03b1 phosphorylation and a decrease of 4E\u2010BP1 phosphorylation, leading to increased binding of 4E\u2010BP1 to m7 GTP. These results indicate that the <jats:italic>R. rosea<\/jats:italic> extract and salidroside inhibit translation initiation. Furthermore, both the <jats:italic>R. rosea<\/jats:italic> extract and salidroside treatment of UMUC3 cells caused a significant percentage of cells undergoing autophagy. Therefore, the <jats:italic>R. rosea<\/jats:italic> extract and salidroside deserve further study as novel agents for chemoprevention of bladder carcinogenesis. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/mc.20780","type":"journal-article","created":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T17:22:14Z","timestamp":1303492934000},"page":"257-267","source":"Crossref","is-referenced-by-count":98,"title":["<i>Rhodiola rosea<\/i> extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy"],"prefix":"10.1002","volume":"51","author":[{"given":"Zhongbo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne R.","family":"Simoneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahtab","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Zi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,22]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"HornerMJ RiesLA KrapchoM et al. eds.SEER Cancer Statistics Review 1975\u20132006. 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