{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:00:56Z","timestamp":1768770056802,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T00:00:00Z","timestamp":1304294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recent genome wide association study (GWAS) indentified a significant association between rs2294008 (C\u2009&gt;\u2009T) polymorphism in prostate stem\u2010cell antigen (<jats:italic>PSCA<\/jats:italic>) and increased risk of gastric cancer in Japanese and Korean populations. The aim of this study was to determine whether rs2294008 polymorphism is associated with risk of gastric cancer in a Korean population. We conducted a large\u2010scale case\u2013control study of 3,245 gastric cancer patients and 1,700 controls. The frequencies of the CC, CT, and TT genotypes of rs2294008 polymorphism were 17.8%, 49.9%, and 32.3% in the gastric cancer patients; and 24.4%, 48.1%, and 27.5% in the controls, respectively. We found that the CT and TT genotypes were associated with a significantly increased risk of gastric cancer (OR<jats:sub>CT<\/jats:sub>\u2009=\u20091.50, 95% confidence intervals, 95% CI: 1.28\u20131.76; OR<jats:sub>TT<\/jats:sub>\u2009=\u20091.71, 95% CI: 1.43\u20132.04), compared with the CC genotype. Further, stratified by tumor location and histological type, the effect of the rs2294008 T allele was larger in cardia (OR<jats:sub>TT<\/jats:sub>\u2009=\u20092.62, 95% CI\u2009=\u20091.42\u20134.85) than non\u2010cardia (OR<jats:sub>TT<\/jats:sub>\u2009=\u20091.67, 95% CI\u2009=\u20091.40\u20132.00), in diffuse\u2010type (OR<jats:sub>TT<\/jats:sub>\u2009=\u20092.00, 95% CI: 1.55\u20132.59) than in intestinal\u2010type (OR<jats:sub>TT<\/jats:sub>\u2009=\u20091.51, 95% CI: 1.22\u20131.86). Our study showed that rs2294008 in the <jats:italic>PSCA<\/jats:italic> gene was associated with increased risks of gastric cancer in a Korean population, suggests that rs2294008 might play an important role in gastric carcinogenesis. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/mc.20796","type":"journal-article","created":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T16:11:15Z","timestamp":1304352675000},"page":"871-875","source":"Crossref","is-referenced-by-count":39,"title":["Association of a common genetic variant in prostate stem\u2010cell antigen with gastric cancer susceptibility in a Korean population"],"prefix":"10.1002","volume":"50","author":[{"given":"Hye\u2010Rim","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee 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