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We have previously reported that anthocyanin\u2010rich black currant skin extract (BCSE) inhibits diethylnitrosamine (DENA)\u2010initiated hepatocarcinogenesis in rats although the underlying mechanisms are not fully understood. Our present study investigates the anti\u2010inflammatory mechanisms of BCSE during DENA rat liver carcinogenesis. Dietary BCSE (100 or 500\u2009mg\/kg) treatment for 22\u2009wk afforded a striking inhibition of DENA\u2010induced hepatic gamma\u2010glutamyl transpeptidase\u2010positive preneoplastic foci in a dose\u2010responsive fashion. There was a significant increase in hepatic expression of heat shock proteins (HSP70 and HSP90), cyclooxygenase\u20102, and nuclear factor\u2010\u03baB (NF\u2010\u03baB) in DENA\u2010exposed rat livers. Dietary BCSE dose\u2010dependently abrogated all these elevated inflammatory markers. The possible cardiotoxicity of BCSE was assessed by monitoring cardiac functions using transthoracic echocardiography. BCSE\u2010mediated anti\u2010inflammatory effects during rat liver carcinogenesis have been achieved without any cardiotoxicity. Our results provide convincing evidence, for the very first time, that suppression of the inflammatory cascade through modulation of the NF\u2010\u03baB signaling pathway could be implicated, at least in part, in the chemopreventive effects of black currant bioactive phytoconstituents against experimental hepatocarcinogenesis. These results coupled with an excellent safety profile of BCSE support the development of black currant phytochemicals for the chemoprevention of inflammation\u2010driven hepatocellular cancer. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/mc.21860","type":"journal-article","created":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T13:41:46Z","timestamp":1324993306000},"page":"304-317","source":"Crossref","is-referenced-by-count":35,"title":["Black currant phytoconstituents exert chemoprevention of diethylnitrosamine\u2010initiated hepatocarcinogenesis by suppression of the inflammatory response"],"prefix":"10.1002","volume":"52","author":[{"given":"Anupam","family":"Bishayee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslin J.","family":"Thoppil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Animesh","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altaf S.","family":"Darvesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahagn","family":"Ohanyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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