{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:13:00Z","timestamp":1761743580319},"reference-count":48,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T00:00:00Z","timestamp":1324944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Xeroderma pigmentosum complementation group C and G (<jats:italic>XPC<\/jats:italic>, <jats:italic>XPG<\/jats:italic>) play important roles in DNA damage repairing machinery. Genetic variations in the <jats:italic>XPC<\/jats:italic> and <jats:italic>XPG<\/jats:italic> may be associated with increased risk for colorectal carcinoma (CRC). In this study, we evaluated the relation between the <jats:italic>XPC<\/jats:italic> Lys939Gln, <jats:italic>XPG<\/jats:italic> Asp1104His polymorphisms, and CRC susceptibility in a population\u2010based case\u2013control study, which included 1,028 CRC cases and 1,085 controls. Compared with the corresponding wild genotypes, we found that individuals with at least one copy of the <jats:italic>XPC<\/jats:italic> Lys939Gln (AC or CC genotype) and <jats:italic>XPG<\/jats:italic> Asp1104His (GC or CC genotype) had an increased risk for CRC. In addition, the variant genotypes of the <jats:italic>XPC<\/jats:italic> Lys939Gln AC\/CC (<jats:italic>P<\/jats:italic>\u2009=\u20090.027) or <jats:italic>XPG<\/jats:italic> Asp1104His GC\/CC (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) reduced the elevation of preoperative carcinoembryonic antigen (CEA) level. Moreover a significantly longer progression\u2010free survival (PFS) after Oxaliplatin\u2010based adjuvant chemotherapy was observed in patients with <jats:italic>XPG<\/jats:italic> Asp1104His wide\u2010type GG genotype (<jats:italic>n<\/jats:italic>\u2009=\u2009432, Log\u2010rank test: <jats:italic>P<\/jats:italic>\u2009=\u20090.033). Cox proportional hazards analyses demonstrated that variant genotypes of <jats:italic>XPG<\/jats:italic> Asp1104His [hazard ratio (HR)\u2009=\u20091.692, 95% confidence interval (95%CI): 1.202\u20132.383, <jats:italic>P<\/jats:italic>\u2009=\u20090.003] as well as pathology grade (HR\u2009=\u20092.545, 95%CI: 2.139\u20133.030, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and lymph node metastases (HR\u2009=\u20091.851, 95%CI: 1.306\u20132.625, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were predictive of shorter PFS for the CRC patients with Oxaliplatin\u2010based adjuvant chemotherapy. In conclusion, the current data suggested that <jats:italic>XPC<\/jats:italic> Lys939Gln and <jats:italic>XPG<\/jats:italic> Asp1104His polymorphisms might contribute to the identification of patients with increased risk for CRC. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/mc.21862","type":"journal-article","created":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T13:37:18Z","timestamp":1324993038000},"source":"Crossref","is-referenced-by-count":22,"title":["DNA repair genes <i>XPC<\/i>, <i>XPG<\/i> polymorphisms: Relation to the risk of colorectal carcinoma and therapeutic outcome with oxaliplatin\u2010based adjuvant 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