{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:52:01Z","timestamp":1783129921506,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T00:00:00Z","timestamp":1331856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the astrocyte elevated gene\u20101 (AEG\u20101) expression and its relationship with the clinicopathological features of colorectal carcinoma (CRC) and \u03b2\u2010catenin signaling pathway. Real\u2010time PCR, Western blot, immunohistochemistry, and immunofluorescence staining were performed to detect AEG\u20101 expression in CRC cell lines, 8 pairs of fresh CRC and adjacent nontumor tissues (ANT), 120 pairs of paraffin\u2010embedded CRC specimens and ANT tissues, and 60 samples of lymph node metastatic CRC tissues. Scratch wound assay and transwell matrix penetration assay were performed to determine migration and invasion of SW480 cell lines with stable AEG\u20101 overexpression or SW620 cell lines with AEG\u20101 knockdown. AEG\u20101 expression was upregulated in CRC cell lines and tissues compared with ANT. Furthermore, AEG\u20101 expression level significantly correlated with UICC stage, and the N classification. AEG\u20101 overexpression significantly enhanced migration and invasion of SW480 cell lines. However, AEG\u20101 knockdown suppressed migration and invasion of SW620 cell lines. Meanwhile, there was a positive correlation between AEG\u20101 high expression and \u03b2\u2010catenin nuclear expression in CRC. AEG\u20101 overexpression increased nuclear \u03b2\u2010catenin accumulation in CRC cell lines. AEG\u20101 knockdown decreased nuclear \u03b2\u2010catenin accumulation in CRC cell lines. Moreover, we firstly found that AEG\u20101 interacted with \u03b2\u2010catenin in SW480 cell lines. Our results for the first time showed that AEG\u20101 interacted with \u03b2\u2010catenin in CRC cells and AEG\u20101 expression was closely associated with progression of CRC. AEG\u20101 might be a potential therapeutic target in CRC. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/mc.21894","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T12:30:03Z","timestamp":1331901003000},"page":"603-610","source":"Crossref","is-referenced-by-count":32,"title":["Astrocyte elevated gene\u20101 interacts with \u03b2\u2010catenin and increases migration and invasion of colorectal 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