{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:16:15Z","timestamp":1772205375494,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T00:00:00Z","timestamp":1361232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Mammalian target of rapamycin complex 1 (mTORC1) plays an important role in maintaining proper cellular functions, and genetic variations in this complex may affect cancer risk. In this study, we examined the associations between eight potential functional single nucleotide polymorphisms in the mTORC1 genes (rs2536T&gt;C and rs1883965G&gt;A for <jats:italic>mTOR<\/jats:italic>, rs3160T&gt;C, and rs26865A&gt;G for <jats:italic>mLST8<\/jats:italic>, rs3751934C&gt;A, rs1062935T&gt;C, rs3751932T&gt;C, and rs12602885G&gt;A for <jats:italic>Raptor<\/jats:italic>, not included in published gastric cancer genome\u2010wide association studies) and gastric cancer risk in 1125 gastric cancer cases and 1196 cancer\u2010free controls. We performed conditional logistic regression and multifactor dimensionality reduction (MDR) analyses to assess their associations with gastric cancer risk. We also used false\u2010positive report probabilities (FPRP) for assessing significant findings. We found that only the rs1883965A variant genotypes were associated with an increased risk of gastric cancer (AG vs. GG: adjusted odds ratio (OR)\u2009=\u20091.26, 95% confidence interval (CI)\u2009=\u20091.00\u20131.59; AA vs. GG: adjusted OR\u2009=\u20091.85, 95% CI\u2009=\u20090.67\u20135.16 and dominant model: adjusted OR\u2009=\u20091.28, 95% CI\u2009=\u20091.03\u20131.61). Patients with \u22651 risk genotypes of <jats:italic>mTOR<\/jats:italic> had significant increased risk (adjusted OR\u2009=\u20091.25, 95% CI\u2009=\u20091.04\u20131.49), compared with those having zero risk genotypes. In the stratified analysis, the risk effect of the rs1883965 AG\/AA genotypes was evident in subgroups of ever\u2010smokers, non\u2010gastric cardia adenocarcinoma and clinical stage I\u2009+\u2009II, which were noteworthy findings as evaluated by FPRP. The MDR analysis identified smoking status and rs1883965 as the strongest two\u2010factors for gastric cancer risk. These data support the hypothesis that functional polymorphisms of <jats:italic>mTOR<\/jats:italic> may contribute to gastric cancer risk. Clearly, our results require validation in larger studies with different ethnic populations. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22013","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T20:40:19Z","timestamp":1361306419000},"page":"70-79","source":"Crossref","is-referenced-by-count":102,"title":["Genetic variations of mTORC1 genes and risk of gastric cancer in an eastern chinese population"],"prefix":"10.1002","volume":"52","author":[{"given":"Jing","family":"He","sequence":"first","affiliation":[{"name":"Cancer Institute Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng\u2010Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Institute Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of 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