{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:17:34Z","timestamp":1740104254924,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant Miller Cancer Research Award, Faculty of Medicine, University of Toronto"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 CA97075, as part of the PACGENE consortium"],"award-info":[{"award-number":["R01 CA97075, as part of the PACGENE consortium"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute, National Institutes of Health","award":["CA-95-011"],"award-info":[{"award-number":["CA-95-011"]}]},{"name":"Ontario Registry for Studies of Familial Colorectal Cancer","award":["U01 CA074783 and through cooperative agreements with members of the Colon Cancer Family Registry (CFRs) and Principle Investigators, and the National Cancer Institute of Canada [grant number 13304]. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the CFRs, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the CFR"],"award-info":[{"award-number":["U01 CA074783 and through cooperative agreements with members of the Colon Cancer Family Registry (CFRs) and Principle Investigators, and the National Cancer Institute of Canada [grant number 13304]. The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the CFRs, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government or the CFR"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Mitotic regulator genes have been associated with several cancers, however little is known about their possible association with pancreatic cancer. Smoking and family history are the strongest risk factors for this highly fatal disease. The main purpose of this study was to determine if polymorphisms of mitotic regulator genes are associated with pancreatic cancer and whether they modify the association between cigarette smoking and pancreatic cancer risk. A population\u2010based case\u2010control study was conducted in Ontario with 455 pathology\u2010confirmed pancreatic cancer cases and 893 controls. Cigarette smoking history was collected using questionnaires and DNA obtained from blood samples. Genotypes were determined by mass\u2010spectrometry. Odds ratio estimates were obtained using multivariate logistic regression. Interactions between genetic variant and smoking were assessed using stratified analyses and the likelihood ratio statistic (significance <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Variants of <jats:italic>MCPH1<\/jats:italic>, <jats:italic>FYN<\/jats:italic>, <jats:italic>APC<\/jats:italic>, <jats:italic>PRKCA<\/jats:italic>, <jats:italic>NIN<\/jats:italic>, <jats:italic>TopBP1<\/jats:italic>, <jats:italic>RIPK1<\/jats:italic>, and <jats:italic>SNW1<\/jats:italic> were not independently associated with pancreatic cancer risk. A significant interaction was observed between pack\u2010years and <jats:italic>MCPH1<\/jats:italic>\u20102550\u2010C\u2009&gt;\u2009T (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Compared to never smokers, individuals with 10\u201327 pack\u2010years and <jats:italic>MCPH1<\/jats:italic>\u20102550\u2010CC genotype were at increased risk for pancreatic cancer (MVOR\u2009=\u20092.49, 95% confidence interval [95% CI]: 1.55, 4.00) as were those with &gt;27 pack\u2010years and <jats:italic>MCPH1<\/jats:italic>\u20102550\u2010TC genotype (MVOR\u2009=\u20092.42, 95% CI: 1.45, 4.05). A significant interaction was observed between smoking status and <jats:italic>TopBP1<\/jats:italic>\u20103257\u2010A\u2009&gt;\u2009G (<jats:italic>P<\/jats:italic>\u2009=\u20090.04) using a dominant model. Current smokers with the <jats:italic>TopBP1<\/jats:italic>\u20103257 A allele were at increased risk for pancreatic cancer (MVOR\u2009=\u20092.55, 95% CI: 1.77, 3.67). <jats:italic>MCPH1<\/jats:italic>\u20102550\u2010C\u2009&gt;\u2009T and <jats:italic>TopBP1<\/jats:italic>\u20103257\u2010A\u2009&gt;\u2009G modify the association between smoking and pancreatic cancer. These findings provide insights into the potential molecular mechanisms behind smoking\u2010associated pancreatic cancer. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22037","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T12:14:37Z","timestamp":1371039277000},"page":"103-109","source":"Crossref","is-referenced-by-count":5,"title":["Interaction of polymorphisms in mitotic regulator genes with cigarette smoking and pancreatic cancer risk"],"prefix":"10.1002","volume":"52","author":[{"given":"Ji\u2010Hyun","family":"Jang","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Toronto Toronto, Ontario Canada"},{"name":"Prevention and Cancer Control Cancer Care Ontario Toronto, Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Cotterchio","sequence":"additional","affiliation":[{"name":"Prevention and Cancer Control Cancer Care Ontario Toronto, Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayelet","family":"Borgida","sequence":"additional","affiliation":[{"name":"Dr. Zane Cohen Digestive Diseases Clinical Research Centre Mount Sinai Hospital Toronto, Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Princess Margaret Hospital University Health Network Toronto, Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Gallinger","sequence":"additional","affiliation":[{"name":"Dr. Zane Cohen Digestive Diseases Clinical Research Centre Mount Sinai Hospital Toronto, Ontario Canada"},{"name":"Department of Surgery University Health Network, University of Toronto Toronto, Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean P.","family":"Cleary","sequence":"additional","affiliation":[{"name":"Department of Surgery University Health Network, University of Toronto Toronto, Ontario Canada"},{"name":"Prosserman Center for Health Research Samuel Lunenfeld Research Institute Toronto, Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-006-0193-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm019"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/302262"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0929-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0404-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.05.030"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0486"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0629"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0734"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0648"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22884"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9303-5"},{"key":"e_1_2_7_14_1","first-page":"81","article-title":"Ontario familial colon cancer registry: Methods and first\u2010year response rates","volume":"21","author":"Cotterchio M","year":"2000","journal-title":"Chronic Dis Can"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs028"},{"key":"e_1_2_7_16_1","unstructured":"National Center for Biotechnology Information dbSNP Short Genetic Variations.http:\/\/www.ncbi.nlm.nih.gov\/projects\/SNP(February 5 2012 date last accessed)."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.79.3.340"},{"key":"e_1_2_7_18_1","unstructured":"Gregory Warnes with contributions from Gregor Gorjanc Friedrich Leisch and Michael Man. 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