{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:33:59Z","timestamp":1793334839848,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea","award":["0720570"],"award-info":[{"award-number":["0720570"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>A recent genome\u2010wide association study (GWAS) identified new susceptibility single\u2010nucleotide polymorphisms (SNPs) rs13361707 (PRKAA1 and PTGER4 gene on 5p13.1) and rs9841504 (ZBTB20 gene on 3q13.31) that were significantly associated with non\u2010cardia gastric cancer. The aim of this study was to determine whether rs13361707 and rs9841504 polymorphisms are associated with the risk of gastric cancer in a Korean population. We conducted a large\u2010scale case\u2013control study of 3245 gastric cancer patients and 1700 controls. The allele frequencies for rs13361707 C and rs9841504 G were 53.5% and 18.3% among gastric cancer cases, compared with 47.1% and 17.2% among controls, respectively. We found that rs13361707 TC and CC genotypes were associated with increased risk for gastric cancer (odds ratios [OR]\u2009=\u20091.29; 95% confidence interval [CI]\u2009=\u20091.11\u20131.51 for TC vs. TT and 1.68; 1.41\u20132.01 for CC vs. TT). However, we found no significant association between rs9841504 and gastric cancer risk (OR\u2009=\u20091.11; 0.97\u20131.28 for CG vs. CC; OR\u2009=\u20091.09; 0.77\u20131.53 for GG vs. CC). We observed no significant interactions between rs13361707 and rs9841504 polymorphisms and age, gender, smoking habit, alcohol consumption, and clinicopathologic characteristics such as anatomical tumor location and histological type. Our study showed that the rs13361707 polymorphism was associated with increased risk of gastric cancer in a Korean population. This finding provides further evidence that genetic variant of PRKAA1 and PTGER4 genes may contribute to the gastric carcinogenesis. However, we found no association between rs9841504 and gastric cancer risk. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22063","type":"journal-article","created":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T06:54:39Z","timestamp":1374044079000},"page":"155-160","source":"Crossref","is-referenced-by-count":30,"title":["Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population"],"prefix":"10.1002","volume":"52","author":[{"given":"Hye\u2010Rim","family":"Song","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Nam","family":"Kim","sequence":"additional","affiliation":[{"name":"Genome Research Center for Hematopoietic Diseases Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun\u2010Seog","family":"Kweon","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Chonnam National University Medical School Gwangju Korea"},{"name":"Jeonnam Regional Cancer Center Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Su","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jeong","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hee","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik Joo","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery Chonnam National University Hwasun Hospital Hwasun Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo\u2010Duk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Woong","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Gwangju Health College Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Chonnam National University Medical School Gwangju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2012.44.1.25"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i3.354"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2011.09.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.152"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.649"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.648"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20796"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.058"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24519"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.978"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25228"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20565"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.11.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2010.488215"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1677\/JME-09-0063"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2249"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2008.01.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20120546"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2006.10.005"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00162-7"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(02)00023-9"}],"container-title":["Molecular 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