{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:18:26Z","timestamp":1740104306015,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,10,12]],"date-time":"2014-10-12T00:00:00Z","timestamp":1413072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000064","name":"US National Center for Complementary and Alternative Medicine","doi-asserted-by":"crossref","award":["R21AT005383","R01AT007395"],"award-info":[{"award-number":["R21AT005383","R01AT007395"]}],"id":[{"id":"10.13039\/100000064","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korea Government","award":["2012-0005755"],"award-info":[{"award-number":["2012-0005755"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:label\/><jats:p><jats:italic>Angelica gigas<\/jats:italic> Nakai (AGN) root ethanol extract exerts anti\u2010cancer activity in several allograft and xenograft models. Here we examined its chemopreventive efficacy through gavage administration against primary carcinogenesis in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Male C57BL\/6 TRAMP mice and wild type littermates were given a daily gavage (5\u2009mg\/mouse, Monday\u2013Friday) of AGN or vehicle, beginning at 8\u2009wk of age (WOA). All mice were terminated at 24 WOA, unless earlier euthanasia was necessitated by large tumors. Whereas AGN\u2010treated TRAMP mice decreased dorsolateral prostate lesion growth by 30% (<jats:italic>P<\/jats:italic>\u2009=\u20090.009), they developed fewer and smaller neuroendocrine\u2010carcinomas (NE\u2010Ca) (0.12\u2009g\/mouse) than vehicle\u2010treated counterparts (0.81\u2009g\/mouse, <jats:italic>P<\/jats:italic>\u2009=\u20090.037). We analyzed the proteome and transcriptome of banked NE\u2010Ca to gain molecular insights. Angiogenesis\u2010antibody array detected a substantial reduction in AGN\u2010treated NE\u2010Ca of basic fibroblast growth factor (FGF2), an angiogenesis stimulator. iTRAQ proteomics plus data mining suggested changes of genes upstream and downstream of FGF2 functionally consistent with AGN inhibiting FGF2\/FGFR1 signaling at different levels of the transduction cascade. Moreover, AGN upregulated mRNA of genes related to immune responses, restored expression of many tumor suppressor genes, and prostate function and muscle differentiation genes. On the other hand, AGN down\u2010regulated mRNA of genes related to neuron signaling, oncofetal antigens, inflammation, and mast cells, Wnt signaling, embryonic morphogenesis, biosynthesis, cell adhesion, motility, invasion, and angiogenesis. These changes suggest not only multiple cancer cell targeting actions of AGN but also impact on the tumor microenvironments such as angiogenesis, inflammation, and immune surveillance. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22230","type":"journal-article","created":{"date-parts":[[2014,10,12]],"date-time":"2014-10-12T18:23:15Z","timestamp":1413138195000},"page":"1567-1583","source":"Crossref","is-referenced-by-count":15,"title":["Chemopreventive effect of Korean <i>Angelica<\/i> root extract on TRAMP carcinogenesis and integrative \u201comic\u201d profiling of affected neuroendocrine carcinomas"],"prefix":"10.1002","volume":"54","author":[{"given":"Jinhui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Texas Tech University Health Sciences Center School of Pharmacy Amarillo Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Hormel Institute University of Minnesota Austin Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Texas Tech University Health Sciences Center School of Pharmacy Amarillo Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Texas Tech University Health Sciences Center School of Pharmacy Amarillo Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suni","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Texas Tech University Health Sciences Center School of Pharmacy Amarillo Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengguo","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Cancer Preventive Material Development Research Center and Institute College of Oriental Medicine Kyunghee University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Texas Tech University Health Sciences Center School of Pharmacy Amarillo Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxuan","family":"L\u00fc","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Texas Tech University Health Sciences Center School of Pharmacy 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