{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:05:27Z","timestamp":1770743127266,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81272975"],"award-info":[{"award-number":["81272975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81172302"],"award-info":[{"award-number":["81172302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81402270"],"award-info":[{"award-number":["81402270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Cancer stem cells (CSCs) are thought to be responsible for cancer progression and therapeutic resistance but identification of this subpopulation requires selective markers. Fortunately, side population (SP) cells analysis brings a novel method to CSCs study. In this study, we identified SP cells, which are demonstrated rich in CSCs, in four nasopharyngeal carcinoma (NPC) cell lines. We investigated SP cells from HK\u20101 NPC cell line and showed CSCs characteristics in this subpopulation. SP cells displayed greater proliferation and invasion and expressed high levels of CSCs markers than NSP cells. Furthermore, our microRNA microarray analysis of SP versus NSP cells revealed that CD38\u2010related miRNAs were down\u2010regulated in SP cell, but the mRNA and protein level of CD38 were highly expressed in SP cells. We further searched for molecules interacting with CD38 and identified ZAP70, which was also well expressed in SP cells at both mRNA and protein levels. Our results uncover a CD38 pathway that may regulate the proliferation and migration of SP cells from HK\u20101 NPC cell line. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22279","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T15:50:56Z","timestamp":1422460256000},"page":"300-311","source":"Crossref","is-referenced-by-count":11,"title":["CD38 is a putative functional marker for side population cells in human nasopharyngeal carcinoma cell lines"],"prefix":"10.1002","volume":"55","author":[{"given":"Danwei","family":"Zheng","sequence":"first","affiliation":[{"name":"Human Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine Central South University Changsha Hunan P. R. China"},{"name":"Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha Hunan P. R. China"},{"name":"Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center, The Third Xiangya Hospital Central South University Changsha Hunan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Liao","sequence":"additional","affiliation":[{"name":"Human Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine Central South University Changsha Hunan P. R. China"},{"name":"Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha Hunan P. R. China"},{"name":"Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center, The Third Xiangya Hospital Central South University Changsha Hunan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangchao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Human Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine Central South University Changsha Hunan P. R. China"},{"name":"Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha Hunan P. R. China"},{"name":"Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center, The Third Xiangya Hospital Central South University Changsha Hunan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengqiu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology Basic School of Medicine Central South University Changsha Hunan Province P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songshu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics The Third Xiangya Hospital Central South University Changsha Hunan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyu","family":"He","sequence":"additional","affiliation":[{"name":"Human Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine Central South University Changsha Hunan P. R. China"},{"name":"Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha Hunan P. R. China"},{"name":"Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center, The Third Xiangya Hospital Central South University Changsha Hunan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Pei","sequence":"additional","affiliation":[{"name":"Human Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine Central South University Changsha Hunan P. R. China"},{"name":"Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha Hunan P. R. China"},{"name":"Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center, The Third Xiangya Hospital Central South University Changsha Hunan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Human Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine Central South University Changsha Hunan P. R. China"},{"name":"Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha Hunan P. R. China"},{"name":"Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center, The Third Xiangya Hospital Central South University Changsha Hunan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Human Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine Central South University Changsha Hunan P. R. China"},{"name":"Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha Hunan P. R. China"},{"name":"Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center, The Third Xiangya Hospital Central South University Changsha Hunan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044579X02000858"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(04)00119-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23727"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328305a0e8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000196821.87655.d0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3253"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-0079-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/35102167"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1232"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1590"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.26417"},{"key":"e_1_2_7_13_1","article-title":"Fibulin\u20103\u2010mediated inhibition of epithelial\u2010to\u2010mesenchymal transition and self\u2010renewal of ALDH+ lung cancer stem cells through IGF1R signaling","author":"Kim IG","year":"2013","journal-title":"Oncogene"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073872"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.02.020"},{"key":"e_1_2_7_16_1","article-title":"Epithelial\u2010to\u2010mesenchymal transition: What is the impact on breast cancer stem cells and drug resistance","author":"Mallini P","year":"2013","journal-title":"Cancer Treat Rev"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-009-0111-2"},{"key":"e_1_2_7_18_1","first-page":"5821","article-title":"Identification of a cancer stem cell in human brain tumors","volume":"63","author":"Singh SK","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03128"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt192"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.11.046"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1797"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065750"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28341"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.177"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243014"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.01.007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0116"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.161"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0592"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-267344"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4343"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.1840"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.36"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.08.003"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-094029"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-109249"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08725.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00146"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.260"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04350.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24003"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2408"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21068"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/590393"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-006-0251-9"},{"key":"e_1_2_7_47_1","first-page":"241","article-title":"Cancer stem\u2010like side population cells in the human nasopharyngeal carcinoma cell line cne\u20102 possess epithelial mesenchymal transition properties in association with metastasis","volume":"28","author":"Guo D","year":"2012","journal-title":"Oncol Rep"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056324"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300010"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-006-0025-7"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2011.09.013"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.88"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0721"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2008.02.005"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002700"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2913"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.08.005"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-013003"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-275610"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065016"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208621"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05682-11"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.22279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.22279","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.22279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:11:32Z","timestamp":1695485492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.22279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/mc.22279"],"URL":"https:\/\/doi.org\/10.1002\/mc.22279","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,28]]}}}