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Previously, our results showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. In this study, we determined that CCL18 expression was up\u2010regulated in ovarian carcinoma compared with adjacent tissue and was expressed in carcinoma cells in the tumor and not in normal ovarian epithelial cells by laser capture microdissection coupled with real\u2010time RT\u2010PCR. Moreover, correlation analysis showed that the CCL18 level was positively correlated with the metastasis of patients with ovarian cancer. Survival analysis also revealed that an increased level of CCL18 was associated with worse survival time in ovarian cancer patients. Over\u2010expression of CCL18 led to enhanced migration and invasion of the Skov3 ovarian cancer cell line in vitro and in vivo. Finally, proteomics analysis demonstrated that CCL18\u2010mediated ovarian cancer invasiveness was strongly correlated with the mTORC2 pathway. These findings suggest that the CCL18 chemokine has an important role in chemokine\u2010mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. \u00a9 2015 The Authors. <jats:italic>Molecular Carcinogenesis<\/jats:italic> published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22419","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T15:23:38Z","timestamp":1444749818000},"page":"1688-1699","source":"Crossref","is-referenced-by-count":59,"title":["CCL18 from tumor\u2010cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway"],"prefix":"10.1002","volume":"55","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Research Department Affiliated Cancer Hospital of Guangxi Medical University Nanning Gaungxi 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