{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:43:19Z","timestamp":1778751799993,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>Bladder cancer (BC) has a typical aetiology characterized by a multistep carcinogenesis due to environmental exposures, genetic susceptibility, and their interaction. Several lines of evidence suggest that DNA repair plays a role in the development and progression of BC. In particular, the study of individual susceptibility to DNA double strand breaks (DSBs) may provide valuable information on BC risk, and help to identify those patients at high\u2010risk of either recurrence or progression of the disease, possibly personalizing both surveillance and treatment. Among the different DSB markers, the most well characterized is phosphorylation of the histone H2AX (\u03b3\u2010H2AX). We assessed any potential role of \u03b3\u2010H2AX as a molecular biomarker in a case\u2010control study (146 cases and 146 controls) to identify individuals with increased BC risk and at high\u2010risk of disease recurrence or progression. We investigated \u03b3\u2010H2AX levels in peripheral blood mononuclear cells before and after their exposure to ionizing radiation (IR). We did not find any significant difference among cases and controls. However, we observed a significant association between \u03b3\u2010H2AX basal levels and risk of disease recurrence or progression. In particular, both BC patients as a whole and the subgroup of non\u2010muscle invasive BC (NMIBC) with high basal H2AX phosphorylation levels had a decreased risk of recurrence or progression (for all BC HR 0.70, 95%CI 0.52\u20130.94, <jats:italic>P\u2009<\/jats:italic>=\u20090.02; for NMIBC HR 0.68, 95%CI 0.50\u20130.92, <jats:italic>P\u2009<\/jats:italic>=\u20090.01), suggesting a protective effect of basal DSB signaling. Our data suggest that \u03b3\u2010H2AX can be considered as a potential molecular biomarker to identify patients with a higher risk of BC recurrence. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22431","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T11:49:33Z","timestamp":1447933773000},"page":"1833-1842","source":"Crossref","is-referenced-by-count":15,"title":["H2AX phosphorylation level in peripheral blood mononuclear cells as an event\u2010free survival predictor for bladder cancer"],"prefix":"10.1002","volume":"55","author":[{"given":"Valentina","family":"Turinetto","sequence":"first","affiliation":[{"name":"Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Pardini","sequence":"additional","affiliation":[{"name":"Human Genetics Foundation (HuGeF), Turin Italy"},{"name":"Department of Medical Sciences, University of Turin, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Allione","sequence":"additional","affiliation":[{"name":"Human Genetics Foundation (HuGeF), Turin Italy"},{"name":"Department of Medical Sciences, University of Turin, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Fiorito","sequence":"additional","affiliation":[{"name":"Human Genetics Foundation (HuGeF), Turin Italy"},{"name":"Department of Medical Sciences, University of Turin, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Viberti","sequence":"additional","affiliation":[{"name":"Human Genetics Foundation (HuGeF), Turin Italy"},{"name":"Department of Medical Sciences, University of Turin, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Guarrera","sequence":"additional","affiliation":[{"name":"Human Genetics Foundation (HuGeF), Turin Italy"},{"name":"Department of Medical Sciences, University of Turin, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Russo","sequence":"additional","affiliation":[{"name":"Human Genetics Foundation (HuGeF), Turin Italy"},{"name":"Department of Medical Sciences, University of Turin, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Anglesio","sequence":"additional","affiliation":[{"name":"Department of Oncology, Radiation Oncology Unit, S. Luigi Hospital, University of Turin, Orbassano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Ruo Redda","sequence":"additional","affiliation":[{"name":"Department of Oncology, Radiation Oncology Unit, S. Luigi Hospital, University of Turin, Orbassano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Casetta","sequence":"additional","affiliation":[{"name":"Department of Urology, Citt\u00e0 della Salute e della Scienza, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Cucchiarale","sequence":"additional","affiliation":[{"name":"Department of Urology, Clinica Cellini, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Destefanis","sequence":"additional","affiliation":[{"name":"Department of Urology, Citt\u00e0 della Salute e della Scienza, Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Oderda","sequence":"additional","affiliation":[{"name":"Department of Urology, Citt\u00e0 della Salute e della Scienza, Turin 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