{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:33:19Z","timestamp":1773401599048,"version":"3.50.1"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T00:00:00Z","timestamp":1454025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Tunisian Ministry of Higher Education and Scientific Research"},{"name":"Institut Pasteur International Network (RIIP)"},{"name":"University of Nice Sophia Antipolis"},{"name":"French National Institute of Cancer (INCA)"},{"name":"French Association for cancer research (ARC)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Carcinog."],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1002\/mc.22470","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T17:43:26Z","timestamp":1454089406000},"page":"18-35","source":"Crossref","is-referenced-by-count":59,"title":["Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression"],"prefix":"10.1002","volume":"56","author":[{"given":"Ons","family":"Zakraoui","sequence":"first","affiliation":[{"name":"Institut Pasteur de Tunis; LR11IPT04 Laboratoire d'Epid\u00e9miologie Mol\u00e9culaire et de Pathologie Exp\u00e9rimentale Appliqu\u00e9e Aux Maladies Infectieuses; Tunis Tunisia"},{"name":"Universit\u00e9 de Tunis El Manar; Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezary","family":"Marcinkiewicz","sequence":"additional","affiliation":[{"name":"Department of Bioengineering; College of Engineering, Temple University; Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohra","family":"Aloui","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Tunis; LR11IPT04 Laboratoire d'Epid\u00e9miologie Mol\u00e9culaire et de Pathologie Exp\u00e9rimentale Appliqu\u00e9e Aux Maladies Infectieuses; Tunis Tunisia"},{"name":"Universit\u00e9 de Tunis El Manar; Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houcemeddine","family":"Othman","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis El Manar; Tunis Tunisia"},{"name":"Institut Pasteur de Tunis; LR11IPT08 Laboratoire des Venins et Biomol\u00e9cules th\u00e9rapeutiques; Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Gr\u00e9pin","sequence":"additional","affiliation":[{"name":"Department of Biomedical; Centre Scientifique de Monaco, 8 Quai Antoine Ier; Monaco Principality of Monaco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meriam","family":"Haoues","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis El Manar; Tunis Tunisia"},{"name":"Institut Pasteur de Tunis; LR11IPT02 Laboratoire de Recherche sur la Transmission, le Contr\u00f4le et l'Immunobiologie des Infections; Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makram","family":"Essafi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis El Manar; Tunis Tunisia"},{"name":"Institut Pasteur de Tunis; LR11IPT02 Laboratoire de Recherche sur la Transmission, le Contr\u00f4le et l'Immunobiologie des Infections; Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najet","family":"Srairi-Abid","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tunis El Manar; Tunis Tunisia"},{"name":"Institut Pasteur de Tunis; LR11IPT08 Laboratoire des Venins et Biomol\u00e9cules th\u00e9rapeutiques; Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammar","family":"Gasmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib","family":"Karoui","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Tunis; LR11IPT04 Laboratoire d'Epid\u00e9miologie Mol\u00e9culaire et de Pathologie Exp\u00e9rimentale Appliqu\u00e9e Aux Maladies Infectieuses; Tunis Tunisia"},{"name":"Universit\u00e9 de Tunis El Manar; Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Pag\u00e8s","sequence":"additional","affiliation":[{"name":"Institute for Research on Cancer and Aging of Nice (IRCAN) UMR\/7284 U1081; University of Nice Sophia Antipolis; Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadija","family":"Essafi-Benkhadir","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Tunis; LR11IPT04 Laboratoire d'Epid\u00e9miologie Mol\u00e9culaire et de Pathologie Exp\u00e9rimentale Appliqu\u00e9e Aux Maladies Infectieuses; Tunis Tunisia"},{"name":"Universit\u00e9 de Tunis El Manar; Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,29]]},"reference":[{"key":"10.1002\/mc.22470-BIB0001|mc22470-cit-0001","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"10.1002\/mc.22470-BIB0002|mc22470-cit-0002","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/1534735404270757","article-title":"Targeting multiple signaling pathways as a strategy for managing prostate cancer: Multifocal signal modulation therapy","volume":"3","author":"McCarty","year":"2004","journal-title":"Integr Cancer Ther"},{"key":"10.1002\/mc.22470-BIB0003|mc22470-cit-0003","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nbt1137","article-title":"Monoclonal antibody therapy of cancer","volume":"23","author":"Adams","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1002\/mc.22470-BIB0004|mc22470-cit-0004","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1517\/14656560902781907","article-title":"Multitarget drugs: The present and the future of cancer therapy","volume":"10","author":"Petrelli","year":"2009","journal-title":"Expert Opin Pharmacother"},{"key":"10.1002\/mc.22470-BIB0005|mc22470-cit-0005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrd2115","article-title":"Angiogenesis: An organizing principle for drug discovery","volume":"6","author":"Folkman","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1002\/mc.22470-BIB0006|mc22470-cit-0006","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/lrb.2008.63403","article-title":"Reversing cancer from inside and out: Oncogene addiction, cellular senescence, and the angiogenic switch","volume":"6","author":"Felsher","year":"2008","journal-title":"Lymphat Res Biol"},{"key":"10.1002\/mc.22470-BIB0007|mc22470-cit-0007","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: Bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1002\/mc.22470-BIB0008|mc22470-cit-0008","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nrd3266","article-title":"Integrins as therapeutic targets: Lessons and opportunities","volume":"9","author":"Cox","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1002\/mc.22470-BIB0009|mc22470-cit-0009","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrc2353","article-title":"Integrins in angiogenesis and lymphangiogenesis","volume":"8","author":"Avraamides","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"10.1002\/mc.22470-BIB0010|mc22470-cit-0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2748","article-title":"Integrins in cancer: Biological implications and therapeutic opportunities","volume":"10","author":"Desgrosellier","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1002\/mc.22470-BIB0011|mc22470-cit-0011","first-page":"77","article-title":"Standard chemoradiotherapy \u00b1 cilengitide in newly diagnosed glioblastoma (GBM): Updated results and subgroup analyses of the international randomized phase III CENTRIC Trial (EORTC trial 26071-22072\/Canadian Brain tumor Consortium)","volume":"49","author":"Stupp","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1002\/mc.22470-BIB0012|mc22470-cit-0012","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/BJ20051678","article-title":"Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: Insight into the evolution of the snake venom integrin-inhibition system","volume":"395","author":"Sanz","year":"2006","journal-title":"Biochem J"},{"key":"10.1002\/mc.22470-BIB0013|mc22470-cit-0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2004.07.028","article-title":"Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom","volume":"45","author":"Ogawa","year":"2005","journal-title":"Toxicon Off J Int Soc Toxinology"},{"key":"10.1002\/mc.22470-BIB0014|mc22470-cit-0014","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2174\/1381612053381765","article-title":"Functional characteristic of snake venom disintegrins: Potential therapeutic implication","volume":"11","author":"Marcinkiewicz","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1002\/mc.22470-BIB0015|mc22470-cit-0015","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1007\/s00018-006-6315-0","article-title":"Snake venom components and their applications in biomedicine","volume":"63","author":"Koh","year":"2006","journal-title":"Cell Mol Life Sci CMLS"},{"key":"10.1002\/mc.22470-BIB0016|mc22470-cit-0016","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1016\/S0021-9258(18)92826-7","article-title":"Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri","volume":"266","author":"Scarborough","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1002\/mc.22470-BIB0017|mc22470-cit-0017","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/labinvest.3700350","article-title":"Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis","volume":"85","author":"Olfa","year":"2005","journal-title":"Lab Investig J Tech Methods Pathol"},{"key":"10.1002\/mc.22470-BIB0018|mc22470-cit-0018","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.toxicon.2012.09.005","article-title":"The continuing saga of snake venom disintegrins","volume":"62","author":"Calvete","year":"2013","journal-title":"Toxicon Off J Int Soc Toxinology"},{"key":"10.1002\/mc.22470-BIB0019|mc22470-cit-0019","first-page":"192","article-title":"Viper venom components affecting angiogenesis","volume":"31","author":"Huang","year":"2001","journal-title":"Haemostasis"},{"key":"10.1002\/mc.22470-BIB0020|mc22470-cit-0020","doi-asserted-by":"crossref","first-page":"6617","DOI":"10.2741\/3177","article-title":"Disintegrins in health and disease","volume":"13","author":"McLane","year":"2008","journal-title":"Front Biosci J Virtual Libr"},{"key":"10.1002\/mc.22470-BIB0021|mc22470-cit-0021","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0167-4838(01)00168-6","article-title":"Amino acid structure and characterization of a heterodimeric disintegrin from Vipera lebetina venom","volume":"1547","author":"Gasmi","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/mc.22470-BIB0022|mc22470-cit-0022","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods San Diego Calif"},{"key":"10.1002\/mc.22470-BIB0023|mc22470-cit-0023","doi-asserted-by":"crossref","first-page":"13302","DOI":"10.1021\/bi9906930","article-title":"Structural and functional characterization of EMF10, a Heterodimeric disintegrin from eristocophis macmahoni venom that selectively inhibits \u03b15\u03b21 Integrin","volume":"38","author":"Cezary Marcinkiewicz","year":"1999","journal-title":"Biochemistry"},{"key":"10.1002\/mc.22470-BIB0024|mc22470-cit-0024","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/01.RES.0000266662.98355.66","article-title":"Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis","volume":"100","author":"Staniszewska","year":"2007","journal-title":"Circ Res"},{"key":"10.1002\/mc.22470-BIB0025|mc22470-cit-0025","first-page":"739","article-title":"Regional differences in the incidence and growth of mouse tumors following intradermal or subcutaneous inoculation","volume":"38","author":"Auerbach","year":"1978","journal-title":"Cancer Res"},{"key":"10.1002\/mc.22470-BIB0026|mc22470-cit-0026","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Sali","year":"1993","journal-title":"J Mol Biol"},{"key":"10.1002\/mc.22470-BIB0027|mc22470-cit-0027","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: The European molecular biology open software suite","volume":"16","author":"Rice","year":"2000","journal-title":"Trends Genet TIG"},{"key":"10.1002\/mc.22470-BIB0028|mc22470-cit-0028","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1110\/ps.062416606","article-title":"Statistical potential for assessment and prediction of protein structures","volume":"15","author":"Shen","year":"2006","journal-title":"Protein Sci"},{"key":"10.1002\/mc.22470-BIB0029|mc22470-cit-0029","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by Calpha geometry: Phi,psi and Cbeta deviation","volume":"50","author":"Lovell","year":"2003","journal-title":"Proteins"},{"key":"10.1002\/mc.22470-BIB0030|mc22470-cit-0030","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: Interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/mc.22470-BIB0031|mc22470-cit-0031","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/prot.10389","article-title":"ZDOCK: An initial-stage protein-docking algorithm","volume":"52","author":"Chen","year":"2003","journal-title":"Proteins"},{"key":"10.1002\/mc.22470-BIB0032|mc22470-cit-0032","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0022-2836(03)00991-4","article-title":"Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD","volume":"332","author":"Fujii","year":"2003","journal-title":"J Mol Biol"},{"key":"10.1002\/mc.22470-BIB0033|mc22470-cit-0033","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/prot.22668","article-title":"FiberDock: Flexible induced-fit backbone refinement in molecular docking","volume":"78","author":"Mashiach","year":"2010","journal-title":"Proteins Struct Funct Bioinforma"},{"key":"10.1002\/mc.22470-BIB0034|mc22470-cit-0034","first-page":"16","article-title":"An adaptive dynamic programming algorithm for the side chain placement problem","author":"Leaver-Fay","year":"2005","journal-title":"Pac Symp Biocomput"},{"key":"10.1002\/mc.22470-BIB0035|mc22470-cit-0035","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1126\/science.285.5430.1028","article-title":"Integrin signaling","volume":"285","author":"Giancotti","year":"1999","journal-title":"Science"},{"key":"10.1002\/mc.22470-BIB0036|mc22470-cit-0036","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1101\/gad.190678.112","article-title":"Mutant p53: One name, many proteins","volume":"26","author":"Freed-Pastor","year":"2012","journal-title":"Genes Dev"},{"key":"10.1002\/mc.22470-BIB0037|mc22470-cit-0037","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bbrc.2010.02.163","article-title":"Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)","volume":"396","author":"Norberg","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/mc.22470-BIB0038|mc22470-cit-0038","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1089\/ars.2011.4414","article-title":"Upsides and downsides of reactive oxygen species for cancer: The roles of reactive oxygen species in tumorigenesis, prevention, and therapy","volume":"16","author":"Gupta","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.1002\/mc.22470-BIB0039|mc22470-cit-0039","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1111\/j.1349-7006.2010.01640.x","article-title":"Significance of integrin \u03b1v\u03b25 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin","volume":"101","author":"Yoshioka","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1002\/mc.22470-BIB0040|mc22470-cit-0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrc727","article-title":"Role of integrins in cell invasion and migration","volume":"2","author":"Hood","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1002\/mc.22470-BIB0041|mc22470-cit-0041","first-page":"11058","article-title":"Crystal structure of the disintegrin heterodimer from saw-scaled viper (Echis carinatus) at 1.9","volume":"44","author":"Bilgrami","year":"2005","journal-title":"A resolution. Biochemistry"},{"key":"10.1002\/mc.22470-BIB0042|mc22470-cit-0042","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00432-011-1039-4","article-title":"The CDK inhibitors in cancer research and therapy","volume":"137","author":"Cicenas","year":"2011","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1002\/mc.22470-BIB0043|mc22470-cit-0043","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ctrv.2013.11.009","article-title":"Antiangiogenesis beyond VEGF inhibition: A journey from antiangiogenic single-target to broad-spectrum agents","volume":"40","author":"Limaverde-Sousa","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"10.1002\/mc.22470-BIB0044|mc22470-cit-0044","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.7314\/APJCP.2012.13.10.4855","article-title":"Snake venom: A potent anticancer agent","volume":"13","author":"Jain","year":"2012","journal-title":"Asian Pac J Cancer Prev APJCP"},{"key":"10.1002\/mc.22470-BIB0045|mc22470-cit-0045","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.biocel.2013.06.009","article-title":"Applications of snake venom components to modulate integrin activities in cell-matrix interactions","volume":"45","author":"Marcinkiewicz","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1002\/mc.22470-BIB0046|mc22470-cit-0046","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jcp.20689","article-title":"The p53 tumor suppressor participates in multiple cell cycle checkpoints","volume":"209","author":"Giono","year":"2006","journal-title":"J Cell Physiol"},{"key":"10.1002\/mc.22470-BIB0047|mc22470-cit-0047","doi-asserted-by":"crossref","first-page":"978312","DOI":"10.1155\/2011\/978312","article-title":"Recent advances in p53 research and cancer treatment","volume":"2011","author":"Suzuki","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"10.1002\/mc.22470-BIB0048|mc22470-cit-0048","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","article-title":"Blinded by the light: The growing complexity of p53","volume":"137","author":"Vousden","year":"2009","journal-title":"Cell"},{"key":"10.1002\/mc.22470-BIB0049|mc22470-cit-0049","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35106009","article-title":"Assessing TP53 status in human tumours to evaluate clinical outcome","volume":"1","author":"Soussi","year":"2001","journal-title":"Nat Rev Cancer"},{"key":"10.1002\/mc.22470-BIB0050|mc22470-cit-0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1593\/tlo.09250","article-title":"Targeting p53 for novel anticancer therapy","volume":"3","author":"Wang","year":"2010","journal-title":"Transl Oncol"},{"key":"10.1002\/mc.22470-BIB0051|mc22470-cit-0051","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1158\/1078-0432.CCR-04-2223","article-title":"Cell death independent of caspases: A review","volume":"11","author":"Br\u00f6ker","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1002\/mc.22470-BIB0052|mc22470-cit-0052","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jss.2007.05.020","article-title":"Apoptosis-inducing factor and colon cancer","volume":"151","author":"Millan","year":"2009","journal-title":"J Surg Res"},{"key":"10.1002\/mc.22470-BIB0053|mc22470-cit-0053","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s10495-005-1895-y","article-title":"Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells","volume":"10","author":"Erhart","year":"2005","journal-title":"Apoptosis"},{"key":"10.1002\/mc.22470-BIB0054|mc22470-cit-0054","doi-asserted-by":"crossref","first-page":"e952","DOI":"10.1038\/cddis.2013.484","article-title":"Wentilactone A as a novel potential antitumor agent induces apoptosis and G2\/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras\/Raf\/ERK\/p53-p21 pathway","volume":"4","author":"Lv","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1002\/mc.22470-BIB0055|mc22470-cit-0055","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/sj.onc.1207556","article-title":"Mitogen-activated protein kinases in apoptosis regulation","volume":"23","author":"Wada","year":"2004","journal-title":"Oncogene"},{"key":"10.1002\/mc.22470-BIB0056|mc22470-cit-0056","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.canlet.2009.01.022","article-title":"Targeting the RAF-MEK-ERK pathway in cancer therapy","volume":"283","author":"Montagut","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1002\/mc.22470-BIB0057|mc22470-cit-0057","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"key":"10.1002\/mc.22470-BIB0058|mc22470-cit-0058","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/cdd.2009.33","article-title":"Life and death partners: Apoptosis, autophagy and the cross-talk between them","volume":"16","author":"Eisenberg-Lerner","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1002\/mc.22470-BIB0059|mc22470-cit-0059","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1742-4658.2009.07366.x","article-title":"ERK and cell death: Mechanisms of ERK-induced cell death-Apoptosis, autophagy and senescence","volume":"277","author":"Cagnol","year":"2010","journal-title":"FEBS J"},{"key":"10.1002\/mc.22470-BIB0060|mc22470-cit-0060","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11010-011-1108-7","article-title":"Thrombin-dependent modulation of \u03b21-integrin-mediated signaling up-regulates prolidase and HIF-1\u03b1 through p-FAK in colorectal cancer cells","volume":"361","author":"Karna","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"10.1002\/mc.22470-BIB0061|mc22470-cit-0061","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.toxicon.2008.06.020","article-title":"Suppressive effect and mechanism of saxatilin, a disintegrin from Korean snake (Gloydius saxatilis), in vascular smooth muscle cells","volume":"52","author":"Sohn","year":"2008","journal-title":"Toxicon"},{"key":"10.1002\/mc.22470-BIB0062|mc22470-cit-0062","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/jcem.87.3.8345","article-title":"Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism","volume":"87","author":"Shih","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/mc.22470-BIB0063|mc22470-cit-0063","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/ijc.21478","article-title":"Signalling responses linked to betulinic acid-induced apoptosis are antagonized by MEK inhibitor U0126 in adherent or 3D spheroid melanoma irrespective of p53 status","volume":"118","author":"Rieber","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1002\/mc.22470-BIB0064|mc22470-cit-0064","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/sj.onc.1204062","article-title":"Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53","volume":"20","author":"Bacus","year":"2001","journal-title":"Oncogene"},{"key":"10.1002\/mc.22470-BIB0065|mc22470-cit-0065","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3109\/10715761003667554","article-title":"Reactive oxygen species in cancer","volume":"44","author":"Liou","year":"2010","journal-title":"Free Radic Res"},{"key":"10.1002\/mc.22470-BIB0066|mc22470-cit-0066","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.10119","article-title":"Cellular response to oxidative stress: Signaling for suicide and survival","volume":"192","author":"Martindale","year":"2002","journal-title":"J Cell Physiol"},{"key":"10.1002\/mc.22470-BIB0067|mc22470-cit-0067","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1021\/bi015627o","article-title":"The presence of the WGD motif in CC8 heterodimeric disintegrin increases its inhibitory effect on \u03b1IIb\u03b23, \u03b1v\u03b23, and \u03b15\u03b21 Integrins\u2020","volume":"41","author":"Calvete","year":"2002","journal-title":"Biochemistry"},{"key":"10.1002\/mc.22470-BIB0068|mc22470-cit-0068","doi-asserted-by":"crossref","first-page":"26488","DOI":"10.1074\/jbc.M301860200","article-title":"Vipera lebetina venom contains two disintegrins inhibiting laminin-binding beta1 integrins","volume":"278","author":"Eble","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1002\/mc.22470-BIB0069|mc22470-cit-0069","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1593\/neo.07898","article-title":"Integrins as antimetastatic targets of RGD-independent snake venom components in liver metastasis [corrected]","volume":"10","author":"Rosenow","year":"2008","journal-title":"Neoplasia"},{"key":"10.1002\/mc.22470-BIB0070|mc22470-cit-0070","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/ijc.26018","article-title":"Integrin-dependent response to laminin-511 regulates breast tumor cell invasion and metastasis","volume":"130","author":"Kusuma","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1002\/mc.22470-BIB0071|mc22470-cit-0071","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/micc.12124","article-title":"Neuropilin regulation of angiogenesis, arteriogenesis, and vascular permeability","volume":"21","author":"Plein","year":"2014","journal-title":"Microcirculation"},{"key":"10.1002\/mc.22470-BIB0072|mc22470-cit-0072","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ajpath.2013.04.022","article-title":"Activated PAR-2 regulates pancreatic cancer progression through ILK\/HIF-\u03b1-induced TGF-\u03b1 expression and MEK\/VEGF-A-mediated angiogenesis","volume":"183","author":"Chang","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1002\/mc.22470-BIB0073|mc22470-cit-0073","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jss.2006.10.005","article-title":"TGFbeta1, TGFbeta2, and TGFbeta3 protein expression in gastric carcinomas: Correlation with prognostics factors and patient survival","volume":"139","author":"Vagenas","year":"2007","journal-title":"J Surg Res"},{"key":"10.1002\/mc.22470-BIB0074|mc22470-cit-0074","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3727\/096504013X13639794277761","article-title":"Autocrine-derived epidermal growth factor receptor ligands contribute to recruitment of tumor-associated macrophage and growth of basal breast cancer cells in vivo","volume":"20","author":"Nickerson","year":"2013","journal-title":"Oncol Res"},{"key":"10.1002\/mc.22470-BIB0075|mc22470-cit-0075","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGFbeta in cancer","volume":"134","author":"Massagu\u00e9","year":"2008","journal-title":"Cell"},{"key":"10.1002\/mc.22470-BIB0076|mc22470-cit-0076","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0962-8924(03)00147-8","article-title":"Id proteins in development, cell cycle and cancer","volume":"13","author":"Ruzinova","year":"2003","journal-title":"Trends Cell Biol"},{"key":"10.1002\/mc.22470-BIB0077|mc22470-cit-0077","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1158\/0008-5472.CAN-11-4058","article-title":"VEGF exerts an angiogenesis-independent function in cancer cells to promote their malignant progression","volume":"72","author":"Cao","year":"2012","journal-title":"Cancer Res"},{"key":"10.1002\/mc.22470-BIB0078|mc22470-cit-0078","first-page":"5230","article-title":"Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells","volume":"63","author":"Bachelder","year":"2003","journal-title":"Cancer Res"},{"key":"10.1002\/mc.22470-BIB0079|mc22470-cit-0079","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/sj.bjc.6605539","article-title":"Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity","volume":"102","author":"Jia","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1002\/mc.22470-BIB0080|mc22470-cit-0080","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.gtc.2010.08.017","article-title":"Targeted therapeutic agents for colorectal cancer","volume":"39","author":"Chee","year":"2010","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1002\/mc.22470-BIB0081|mc22470-cit-0081","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2174\/1568011033353452","article-title":"Vascular endothelial cell growth factor (VEGF), an emerging target for cancer chemotherapy","volume":"3","author":"Shinkaruk","year":"2003","journal-title":"Curr Med Chem Anticancer Agents"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.22470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.22470","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/mc.22470\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T19:55:38Z","timestamp":1654199738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.22470"}},"subtitle":["MECHANISMS AND TARGETS FOR LEBEIN IN COLORECTAL CANCER"],"short-title":[],"issued":{"date-parts":[[2016,1,29]]},"references-count":81,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"URL":"https:\/\/doi.org\/10.1002\/mc.22470","archive":["Portico"],"relation":{},"ISSN":["0899-1987"],"issn-type":[{"value":"0899-1987","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,29]]}}}