{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T22:11:36Z","timestamp":1753740696781},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T00:00:00Z","timestamp":1454976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Carl and Leonora Fingerhut Fund Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Carcinog."],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1002\/mc.22473","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T17:49:41Z","timestamp":1455040181000},"page":"62-74","source":"Crossref","is-referenced-by-count":10,"title":["First trimester human placenta prevents breast cancer cell attachment to the matrix: The role of extracellular matrix"],"prefix":"10.1002","volume":"56","author":[{"given":"Gali","family":"Epstein Shochet","sequence":"first","affiliation":[{"name":"Oncogenetic Laboratory; Meir Medical Center; Kfar Saba Israel"},{"name":"Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liat","family":"Drucker","sequence":"additional","affiliation":[{"name":"Oncogenetic Laboratory; Meir Medical Center; Kfar Saba Israel"},{"name":"Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meir","family":"Pomeranz","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv Israel"},{"name":"Department of Obstetrics and Gynecology; Meir Medical Center; Kfar Saba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami","family":"Fishman","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv Israel"},{"name":"Department of Obstetrics and Gynecology; Meir Medical Center; Kfar Saba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metsada","family":"Pasmanik-Chor","sequence":"additional","affiliation":[{"name":"Bioinformatics Unit; Wise Faculty of Life Sciences; Tel Aviv University; Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelly","family":"Tartakover-Matalon","sequence":"additional","affiliation":[{"name":"Oncogenetic Laboratory; Meir Medical Center; Kfar Saba Israel"},{"name":"Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lishner","sequence":"additional","affiliation":[{"name":"Oncogenetic Laboratory; Meir Medical Center; Kfar Saba Israel"},{"name":"Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv Israel"},{"name":"Department of Internal Medicine A; Meir Medical Center; Kfar Saba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"10.1002\/mc.22473-BIB0001|mc22473-cit-0001","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.breast.2013.07.012","article-title":"Extracellular matrix components in breast cancer progression and metastasis","volume":"22","author":"Oskarsson","year":"2013","journal-title":"Breast"},{"key":"10.1002\/mc.22473-BIB0002|mc22473-cit-0002","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1189\/jlb.0506328","article-title":"Native and fragmented fibronectin oppositely modulate monocyte secretion of MMP-9","volume":"81","author":"Marom","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1002\/mc.22473-BIB0003|mc22473-cit-0003","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1096\/fasebj.11.1.9034166","article-title":"Growth factors in the extracellular matrix","volume":"11","author":"Taipale","year":"1997","journal-title":"Faseb J"},{"key":"10.1002\/mc.22473-BIB0004|mc22473-cit-0004","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.diff.2013.03.003","article-title":"Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells","volume":"86","author":"Chen","year":"2013","journal-title":"Differentiation"},{"key":"10.1002\/mc.22473-BIB0005|mc22473-cit-0005","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.semcancer.2008.03.016","article-title":"Can cancer be reversed by engineering the tumor microenvironment","volume":"18","author":"Ingber","year":"2008","journal-title":"Semin Cancer Biol"},{"key":"10.1002\/mc.22473-BIB0006|mc22473-cit-0006","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1083\/jcb.201102147","article-title":"The extracellular matrix: A dynamic niche in cancer progression","volume":"196","author":"Lu","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1002\/mc.22473-BIB0007|mc22473-cit-0007","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1016\/j.bbamcr.2013.06.026","article-title":"Anoikis molecular pathways and its role in cancer progression","volume":"1833","author":"Paoli","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/mc.22473-BIB0008|mc22473-cit-0008","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.1038\/71397","article-title":"Complexity and specificity of integrin signalling","volume":"2","author":"Giancotti","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1002\/mc.22473-BIB0009|mc22473-cit-0009","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1083\/jcb.200408090","article-title":"The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1","volume":"167","author":"Kadrmas","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1002\/mc.22473-BIB0010|mc22473-cit-0010","doi-asserted-by":"crossref","first-page":"a005017","DOI":"10.1101\/cshperspect.a005017","article-title":"Cross talk among TGF-beta signaling pathways, integrins, and the extracellular matrix","volume":"3","author":"Munger","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1002\/mc.22473-BIB0011|mc22473-cit-0011","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nrc3789","article-title":"Cancer cell survival during detachment from the ECM: Multiple barriers to tumour progression","volume":"14","author":"Buchheit","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1002\/mc.22473-BIB0012|mc22473-cit-0012","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1242\/jcs.050906","article-title":"ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells","volume":"123","author":"Haenssen","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1002\/mc.22473-BIB0013|mc22473-cit-0013","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2350\/06-06-0119.1","article-title":"Maternal pancreatic carcinoma metastatic to the placenta: A case report and literature review","volume":"10","author":"Al-Adnani","year":"2007","journal-title":"Pediatr Dev Pathol"},{"key":"10.1002\/mc.22473-BIB0014|mc22473-cit-0014","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1093\/humrep\/deq227","article-title":"Breast cancer characteristics are modified by first trimester human placenta: In vitro co-culture study","volume":"25","author":"Tartakover-Matalon","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1002\/mc.22473-BIB0015|mc22473-cit-0015","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s10585-014-9683-0","article-title":"Placenta-breast cancer cell interactions promote cancer cell epithelial mesenchymal transition via TGFbeta\/JNK pathway","volume":"31","author":"Epstein Shochet","year":"2014","journal-title":"Clin Exp Metastasis"},{"key":"10.1002\/mc.22473-BIB0016|mc22473-cit-0016","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/978-1-4757-4199-5_5","volume-title":"Pathology of the human placenta, in: Early development of the human placenta","author":"Benirschke","year":"2000"},{"key":"10.1002\/mc.22473-BIB0017|mc22473-cit-0017","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1385\/ENDO:19:1:3","article-title":"Hormones and human trophoblast differentiation: A review","volume":"19","author":"Malassine","year":"2002","journal-title":"Endocrine"},{"key":"10.1002\/mc.22473-BIB0018|mc22473-cit-0018","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cytogfr.2009.05.004","article-title":"Cytokine regulation during the formation of the fetal-maternal interface: Focus on cell-cell adhesion and remodelling of the extra-cellular matrix","volume":"20","author":"McEwan","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1002\/mc.22473-BIB0019|mc22473-cit-0019","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF02473239","article-title":"Extracellular matrix components of the placental extravillous trophoblast: Immunocytochemistry and ultrastructural distribution","volume":"106","author":"Huppertz","year":"1996","journal-title":"Histochem Cell Biol"},{"key":"10.1002\/mc.22473-BIB0020|mc22473-cit-0020","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.placenta.2004.11.003","article-title":"Three-dimensional growth of extravillous cytotrophoblasts promotes differentiation and invasion","volume":"26","author":"LaMarca","year":"2005","journal-title":"Placenta"},{"key":"10.1002\/mc.22473-BIB0021|mc22473-cit-0021","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejcb.2011.11.006","article-title":"Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradation","volume":"91","author":"Patel","year":"2012","journal-title":"Eur J Cell Biol"},{"key":"10.1002\/mc.22473-BIB0022|mc22473-cit-0022","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12307-008-0004-5","article-title":"The epigenetic influence of tumor and embryonic microenvironments: How different are they","volume":"1","author":"Abbott","year":"2008","journal-title":"Cancer Microenviron"},{"key":"10.1002\/mc.22473-BIB0023|mc22473-cit-0023","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: An integrated system for exploring gene sets in various biological contexts","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/mc.22473-BIB0024|mc22473-cit-0024","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/mc.22473-BIB0025|mc22473-cit-0025","doi-asserted-by":"crossref","first-page":"W305","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene Suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"Chen","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/mc.22473-BIB0026|mc22473-cit-0026","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1093\/bioinformatics\/btl483","article-title":"GATHER: A systems approach to interpreting genomic signatures","volume":"22","author":"Chang","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1002\/mc.22473-BIB0027|mc22473-cit-0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/mc.22473-BIB0028|mc22473-cit-0028","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11010-007-9551-1","article-title":"Estrogen receptors inhibit Smad3 transcriptional activity through Ap-1 transcription factors","volume":"306","author":"Cherlet","year":"2007","journal-title":"Mol Cell Biochem"},{"key":"10.1002\/mc.22473-BIB0029|mc22473-cit-0029","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/j.1349-7006.2011.01977.x","article-title":"Estrogen and antiestrogens alter breast cancer invasiveness by modulating the transforming growth factor-beta signaling pathway","volume":"102","author":"Goto","year":"2011","journal-title":"Cancer Sci"},{"key":"10.1002\/mc.22473-BIB0030|mc22473-cit-0030","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s10549-009-0393-2","article-title":"Estrogen receptor alpha attenuates transforming growth factor-beta signaling in breast cancer cells independent from agonistic and antagonistic ligands","volume":"120","author":"Stope","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1002\/mc.22473-BIB0031|mc22473-cit-0031","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2174\/138945009788680374","article-title":"Defining the role of integrin alphavbeta6 in cancer","volume":"10","author":"Bandyopadhyay","year":"2009","journal-title":"Curr Drug Targets"},{"key":"10.1002\/mc.22473-BIB0032|mc22473-cit-0032","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/gb-2007-8-5-215","article-title":"The integrins","volume":"8","author":"Takada","year":"2007","journal-title":"Genome Biol"},{"key":"10.1002\/mc.22473-BIB0033|mc22473-cit-0033","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/309030a0","article-title":"Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule","volume":"309","author":"Pierschbacher","year":"1984","journal-title":"Nature"},{"key":"10.1002\/mc.22473-BIB0034|mc22473-cit-0034","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1158\/0008-5472.CAN-10-3453","article-title":"Steroid receptor coactivator-1 upregulates integrin alpha(5) expression to promote breast cancer cell adhesion and migration","volume":"71","author":"Qin","year":"2011","journal-title":"Cancer Res"},{"key":"10.1002\/mc.22473-BIB0035|mc22473-cit-0035","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ctrv.2008.01.002","article-title":"Cancer in pregnancy: Gaps, challenges and solutions","volume":"34","author":"Pereg","year":"2008","journal-title":"Cancer Treat Rev"},{"key":"10.1002\/mc.22473-BIB0036|mc22473-cit-0036","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1095\/biolreprod60.4.828","article-title":"Development of cytotrophoblast columns from explanted first-trimester human placental villi: Role of fibronectin and integrin alpha5beta1","volume":"60","author":"Aplin","year":"1999","journal-title":"Biol Reprod"},{"key":"10.1002\/mc.22473-BIB0037|mc22473-cit-0037","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.humpath.2013.03.006","article-title":"Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer","volume":"44","author":"Bae","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1002\/mc.22473-BIB0038|mc22473-cit-0038","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.lfs.2007.12.013","article-title":"Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium","volume":"82","author":"Das","year":"2008","journal-title":"Life Sci"},{"key":"10.1002\/mc.22473-BIB0039|mc22473-cit-0039","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/his.12300","article-title":"Expression and prognostic significance of fibronectin and matrix metalloproteases in breast cancer metastasis","volume":"64","author":"Fernandez-Garcia","year":"2014","journal-title":"Histopathology"},{"key":"10.1002\/mc.22473-BIB0040|mc22473-cit-0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1359-6101(99)00010-6","article-title":"Latent transforming growth factor-beta binding proteins (LTBPs)-structural extracellular matrix proteins for targeting TGF-beta action","volume":"10","author":"Saharinen","year":"1999","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1002\/mc.22473-BIB0041|mc22473-cit-0041","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/onc.2013.118","article-title":"Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition","volume":"33","author":"Park","year":"2013","journal-title":"Oncogene"},{"key":"10.1002\/mc.22473-BIB0042|mc22473-cit-0042","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.febslet.2012.05.020","article-title":"Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin","volume":"586","author":"Ding","year":"2012","journal-title":"FEBS Lett"},{"key":"10.1002\/mc.22473-BIB0043|mc22473-cit-0043","first-page":"1151","article-title":"Resistance to transforming growth factor beta and activin due to reduced receptor expression in human breast tumor cell lines","volume":"6","author":"Kalkhoven","year":"1995","journal-title":"Cell Growth Differ"},{"key":"10.1002\/mc.22473-BIB0044|mc22473-cit-0044","doi-asserted-by":"crossref","first-page":"e26845","DOI":"10.4161\/tisb.26845","article-title":"JNK is a novel regulator of intercellular adhesion","volume":"1","author":"You","year":"2013","journal-title":"Tissue Barriers"},{"key":"10.1002\/mc.22473-BIB0045|mc22473-cit-0045","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1083\/jcb.201111077","article-title":"Crystal structure of alpha5beta1 integrin ectodomain: Atomic details of the fibronectin receptor","volume":"197","author":"Nagae","year":"2012","journal-title":"J Cell Biol"},{"key":"10.1002\/mc.22473-BIB0046|mc22473-cit-0046","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10238-006-0117-4","article-title":"Stephen Paget and the \u2018seed and soil\u2019 theory of metastatic dissemination","volume":"6","author":"Ribatti","year":"2006","journal-title":"Clin Exp Med"},{"key":"10.1002\/mc.22473-BIB0047|mc22473-cit-0047","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1593\/neo.121950","article-title":"Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics","volume":"15","author":"Dumont","year":"2013","journal-title":"Neoplasia"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.22473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.22473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/mc.22473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T13:07:19Z","timestamp":1625490439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.22473"}},"subtitle":["PLACENTAL INHIBITION OF BREAST CANCER CELL MATRIX ATTACHMENT"],"short-title":[],"issued":{"date-parts":[[2016,2,9]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"URL":"https:\/\/doi.org\/10.1002\/mc.22473","archive":["Portico"],"relation":{},"ISSN":["0899-1987"],"issn-type":[{"value":"0899-1987","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2,9]]}}}