{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:16:22Z","timestamp":1767899782169,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T00:00:00Z","timestamp":1472601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/8\/10\u20103(Oto)CFP\/11\u2010NCD\u20101"],"award-info":[{"award-number":["5\/8\/10\u20103(Oto)CFP\/11\u2010NCD\u20101"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/1\/3\/WL\/JRF\u20102011\/HRD 112"],"award-info":[{"award-number":["3\/1\/3\/WL\/JRF\u20102011\/HRD 112"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Reports on the association of <jats:italic>TP53<\/jats:italic> polymorphisms with oral cancer are not only limited but also not specific to site and\/or gender. Hence, we examined the effect of <jats:italic>TP53<\/jats:italic> polymorphisms (EX4 215G&gt;C, IVS3+40\u201041ins16 and IVS6+62G&gt;A) on buccal mucosa cancer (BMC) and tongue cancer (TC) risk, survival of patients in relation to risk and clinical factors, gender wise (excepting for estimating hazards ratio [HR]), using Fisher's Exact Test, Kaplan\u2013Meier analysis, and Cox\u2010proportional hazards models. The exonic polymorphism increased BMC and TC risk in males by 2\u20134\u2010fold. The IVS3+40\u201041ins16 was protective against BMC and TC in both genders, whereas IVS6+62G&gt;A protected only males against TC. Genotype combinations and haplotypes which altered the risk of cancers in males and females were different. TC males, aged 40\u201344 years and females, aged 55\u201359 years survived better than BMC patients. The IVS3+40\u201041ins16 polymorphism differentially impacted survival of female patients exposed to tobacco. TC patients with EX4 215GC with lymphovascular spread (LVS) and metastasis exhibited higher HR while, patients with EX4 215CC and perineural invasion (PNI) showed lower HR. Impact of the intronic variants along with clinical parameters on survival and HR estimates varied between BMC and TC. Our bioinformatics analysis revealed the presence of CTCF binding site within <jats:italic>TP53<\/jats:italic> gene. In conclusion, the polymorphisms altered risk and survival of BMC and TC in a gender specific manner, which varied with mode of tobacco and\/or alcohol use. The current study, therefore underscores strong need for research, stratified by tumor site and gender. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22543","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T22:52:50Z","timestamp":1471474370000},"page":"895-912","source":"Crossref","is-referenced-by-count":6,"title":["Gender specific association of <i>TP53<\/i> polymorphisms (EX4 215G&gt;C Arg72Pro, IVS3+40\u201041ins16, and IVS6+62G&gt;A), with risk of oral cancer subtypes and overall survival of the patients"],"prefix":"10.1002","volume":"56","author":[{"given":"Srivani L.S.S.","family":"Nagam","sequence":"first","affiliation":[{"name":"Indo\u2010American Cancer Research Foundation Formerly Research and Development, Basavatarakam Indo\u2010American Cancer Hospital and Research Institute Hyderabad Telangana India"},{"name":"Acharya Nagarjuna University Andhra Pradesh 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