{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:24:11Z","timestamp":1787739851575,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,2]],"date-time":"2017-01-02T00:00:00Z","timestamp":1483315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["P50CA097007"],"award-info":[{"award-number":["P50CA097007"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES 011740"],"award-info":[{"award-number":["ES 011740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA131274"],"award-info":[{"award-number":["CA131274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["CA16672"],"award-info":[{"award-number":["CA16672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA135679"],"award-info":[{"award-number":["CA135679"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA133099"],"award-info":[{"award-number":["CA133099"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA186261\u201001A1"],"award-info":[{"award-number":["CA186261\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Because E2F transcription factor 2 (<jats:italic>E2F2<\/jats:italic>) promoter polymorphisms have been implicated in carcinogenesis and prognosis, we investigated associations between genetic variants in five <jats:italic>E2F2<\/jats:italic> promoter polymorphisms and recurrence risk of squamous cell carcinoma of the oropharynx (SCCOP) in 1\u2009008 patients. A log\u2010rank test and multivariable Cox models were used to assess the associations. Compared with patients with variant genotypes of <jats:italic>E2F2<\/jats:italic>\u2010rs2742976 and <jats:italic>E2F2<\/jats:italic>\u2010rs3218123, patients with common homozygous genotypes had better disease\u2010free survival (both log\u2010rank, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001) and lower SCCOP recurrence risk (HR, 0.4, 95% CI, 0.3\u20130.6 and HR, 0.3, 95% CI, 0.2\u20130.5, respectively) after multivariable adjustment. Furthermore, among patients with HPV16\u2010positive tumors, those with common homozygous genotypes of <jats:italic>E2F2<\/jats:italic>\u2010rs2742976 and <jats:italic>E2F2<\/jats:italic>\u2010rs3218123 had better disease\u2010free survival rates (both log\u2010rank, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001) and lower recurrence risk (HR, 0.1, 95% CI, 0.1\u20130.4 and HR, 0.1, 95% CI, 0.0\u20130.2, respectively) than patients with variant genotypes. However, no significant differences were found for the other three polymorphisms. After combining the risk genotypes of the five polymorphisms and using the high\u2010risk group (2\u20135 risk genotypes) as the reference group, we found that the low\u2010risk groups (0 or 1 risk genotype) had significantly lower recurrence risk among all patients (HR, 0.4, 95% CI, 0.3\u20130.6) and among HPV16\u2010positive patients (HR, 0.2, 95% CI, 0.1\u20130.5). Our findings suggest that <jats:italic>E2F2<\/jats:italic> polymorphisms may individually or jointly modify SCCOP recurrence risk, particularly for SCCOP patients with HPV16\u2010positive tumors. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22595","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T11:02:42Z","timestamp":1479553362000},"page":"1335-1343","source":"Crossref","is-referenced-by-count":14,"title":["E2F transcription factor 2 variants as predictive biomarkers for recurrence risk in patients with squamous cell carcinoma of the oropharynx"],"prefix":"10.1002","volume":"56","author":[{"given":"Yuncheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science Technology Wuhan China"},{"name":"Department of Head Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich M.","family":"Sturgis","sequence":"additional","affiliation":[{"name":"Department of Head Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Head Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Oral Maxillofacial Surgery, Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Head Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Ultrasound Yantai Yuhuangding Hospital Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Wei","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Duke Cancer Institute Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Head Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Yuhuangding Hospital of Qingdao University Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Head Neck Surgery The University of Texas MD Anderson Cancer Center Houston Texas"},{"name":"Department of Epidemiology The University of Texas MD Anderson Cancer Center Houston 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