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However, the underlying mechanism of action is not clear. Here, we use the abortifacient metapristone (RU486 derivative) to test the hypothesis that the contraceptives might interrupt CXCL12\/CXCR4 chemokine axis to inhibit ovarian cancer metastasis. Metapristone at concentrations (&lt;IC50) remarkably reduces CXCL12\u2010induced CXCR4 expression on ovarian SKOV\u20103 and IGROV\u20101 cell lines, and down\u2010regulates the CXCR4\u2010related mRNAs and intracellular proteins. Metapristone concentration\u2010dependently inhibits cancer cell proliferation via interfering the CXCL12\u2010activated Akt and ERK signaling pathways. The effect of CXCL12 could be antagonized by AMD3100. Metapristone interrupts the cellular filamentous actin polymerization and the related chemotaxis. Metapristone also concentration\u2010dependently inhibits the events of cellular invasion, migration, and adhesion. The inhibition is related to down\u2010regulation of the invasive molecules MMP\u20102, MMP\u20109, COX\u20102, and VEGF without affecting the adhesion molecules ICAM\u20101, integrins \u03b11, \u03b13, \u03b15, \u03b16, and \u03b21. Six\u2010week in vivo xenograft study confirms the anti\u2010metastatic effect of metapristone on mouse ascites and metastatic foci induced by intraperitoneal IGROV\u20101 and CXCL12. The present studies, for the first time, reveal the therapeutic effect of metapristone on ovarian metastasis and the CXCL12\/CXCR4 axis\u2010related mechanisms of actions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22645","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T13:53:06Z","timestamp":1489067586000},"page":"1896-1908","source":"Crossref","is-referenced-by-count":25,"title":["Abortifacient metapristone (RU486 derivative) interrupts CXCL12\/CXCR4 axis for ovarian metastatic chemoprevention"],"prefix":"10.1002","volume":"56","author":[{"given":"Ning","family":"Zheng","sequence":"first","affiliation":[{"name":"Cancer Metastasis Alert and Prevention Center, and Biopharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou University Fuzhou China"},{"name":"Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy Fuzhou University Fuzhou Fujian 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