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Although the expression pattern of AP\u20102\u03b2 has been analyzed in cervical cancer cell lines, the functions and molecular mechanism of AP\u20102\u03b2 are unknown. Here, we found that AP\u20102\u03b2 significantly inhibits TCF\/LEF reporter activity. Moreover, AP\u20102\u03b2 and \u03b2\u2010catenin interact both in vitro through GST pull\u2010down assays and in vivo by co\u2010immunoprecipitation. We further identified the interaction regions to the DNA\u2010binding domain of AP\u20102\u03b2 and the 1\u20109 Armadillo repeats of \u03b2\u2010catenin. Moreover, AP\u20102\u03b2 binds with \u03b2\u2010TrCP and promotes the degradation of endogenous \u03b2\u2010catenin via the proteasomal degradation pathway. Immunohistochemistry analysis revealed a negative correlation between the two proteins in cervical cancer tissues and cell lines. Finally, functional analysis showed that AP\u20102\u03b2 suppresses cervical cancer cell growth in vitro and in vivo by inhibiting the expression of Wnt downstream genes. Taken together, these findings demonstrated that AP\u20102\u03b2 functions as a novel inhibitor of the Wnt\/\u03b2\u2010catenin signaling pathway in cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22646","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T13:52:43Z","timestamp":1489067563000},"page":"1909-1923","source":"Crossref","is-referenced-by-count":19,"title":["Transcription factor AP\u20102\u03b2 suppresses cervical cancer cell proliferation by promoting the degradation of its interaction partner \u03b2\u2010catenin"],"prefix":"10.1002","volume":"56","author":[{"given":"Fangmei","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Protein Chemistry and Development Biology of State Education Ministry of China, College of Life Science Hunan Normal University  Changsha Hunan 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