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The clinical expression level of hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) reflects the prognosis of a variety of cancers, especially breast cancer. Histone deacetylase (HDAC) inhibitors can target HIF\u20101\u03b1 protein due to von Hippel\u2010Lindau (VHL) protein\u2010dependent degradation. Dietary organosulfur compounds, such as those in garlic, have been reported as HDAC inhibitors. The effects of diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) on the ratio of firefly\/Renilla luciferase activity in hypoxic MDA\u2010MB\u2010231 cells were determined. The mRNA expressions of HIF\u20101\u03b1 target genes ANGPTL4, LOXL4, and LOX in hypoxic MDA\u2010MB\u2010231 cells were significantly down\u2010regulated by DATS. DATS attenuated the metastatic potential of MDA\u2010MB\u2010231 cells in hypoxia\u2010induced embryonic zebrafish, xenograft, and orthotopic tumors. Endothelial cell\u2010cancer cell adhesion, wound healing, transwell, and tube formation assays showed that DATS dose\u2010dependently inhibited the migration and angiogenesis of MDA\u2010MB\u2010231 cells in vitro. The expressions of L1CAM, VEGF\u2010A, and EMT\u2010related proteins (Slug, Snail, MMP\u20102) were inhibited by DATS. DATS dose\u2010dependently inhibited HIF\u20101\u03b1 transcriptional activity and hypoxia\u2010induced hematogenous metastasis of MDA\u2010MB\u2010231 cells. It reduced the protein expression of HIF\u20101\u03b1, which did not involve inhibition of HIF\u20101\u03b1 mRNA expression or ubiquitin proteasome degradation. Efficient inhibition of HIF\u20101\u03b1 expression was required for DATS to resist breast cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mc.22686","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T08:52:42Z","timestamp":1496393562000},"page":"2317-2331","source":"Crossref","is-referenced-by-count":89,"title":["Diallyl trisulfides, a natural histone deacetylase inhibitor, attenuate HIF\u20101\u03b1 synthesis, and decreases breast cancer metastasis"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8911-4159","authenticated-orcid":false,"given":"Zhonghong","family":"Wei","sequence":"first","affiliation":[{"name":"School of Pharmacy Nanjing University of Chinese Medicine Nanjing Jiangsu Province China"},{"name":"Jiangsu Key Laboratory for Pharmacolgy and Safety Evaluation of Chinese Materia Medica Nanjing Jiangsu Province 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