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The major culprit for cancer progression in obesity is presumed to be macrophages. Accumulation of macrophages in adipose tissue due to obesity induced chronic inflammation has been observed. However, obesity\u2010induced macrophage accumulation related to ovarian cancer progression remains unclear. So, the role of macrophage in cancer progression is needed to be further defined for therapeutic intervention. Here we determined the effect of macrophage type 1 (M1 macrophage) on ovarian cancer cells in relation to the metastasis. Ovarian cancer cell lines (PA\u20101, SKOV3) and monocyte\u2010derived macrophages were used in this study. Treatment with M1 macrophage conditioned media on ovarian cancer cells increased the metastatic potential, such as migration and invasion capabilities. Interestingly, upon treatment with M1 macrophage conditioned media, nuclear translocation of NF\u2010\u03baB, p60, and p50, from the cytosol was enhanced together with increased transcriptional activity of the NF\u2010\u03baB. Pre\u2010treatment with TPCK (NF\u2010\u03baB inhibitor) and NF\u2010\u03baB siRNA on ovarian cancer cells suppressed M1 macrophage\u2010induced metastatic potential. Furthermore, Treatment of TNF\u2010\u03b1 on ovarian cancer cells showed NF\u2010\u03baB activation. Co\u2010treatment with TNF\u2010\u03b1 inhibitor, etanercept, and M1 macrophage conditioned media on ovarian cancer cell lines reversed M1 macrophage conditioned media induced NF\u2010\u03baB activation. Taken together, TNF\u2010\u03b1 released from M1 macrophage increased metastatic potential in ovarian cancer cells through the activation of NF\u2010\u03baB signaling pathway. These results provide a new insight into the critical role of M1 macrophage in the tumor microenvironment in ovarian cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22750","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T14:34:41Z","timestamp":1507818881000},"page":"235-242","source":"Crossref","is-referenced-by-count":84,"title":["Pro\u2010inflammatory M1 macrophage enhances metastatic potential of ovarian cancer cells through NF\u2010\u03baB activation"],"prefix":"10.1002","volume":"57","author":[{"given":"Untack","family":"Cho","sequence":"first","affiliation":[{"name":"Cancer Research Institute Seoul National University College of Medicine Seoul Korea"},{"name":"Interdisciplinary Program in Cancer Biology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Cancer Research Institute Seoul National 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