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Unfortunately, mechanistic targets for breaking the links between obesity\u2010associated adipose tissue dysfunction, inflammation, and claudin\u2010low breast cancer growth have not been elucidated. Ovariectomized female C57BL\/6 mice were randomized (<jats:italic>n<\/jats:italic>\u2009=\u200915\/group) to receive a control diet, a diet\u2010induced obesity (DIO) diet, or a DIO\u2009+\u2009resveratrol (0.5% wt\/wt) diet. Mice consumed these diets ad libitum throughout study and after 6 weeks were orthotopically injected with M\u2010Wnt murine mammary tumor cells, a model of estrogen receptor (ER)\u2010negative claudin\u2010low breast cancer. Compared with controls, DIO mice displayed adipose dysregulation and metabolic perturbations including increased mammary adipocyte size, cyclooxygenase\u20102 (COX\u20102) expression, inflammatory eicosanoid levels, macrophage infiltration, and prevalence of crown\u2010like structures (CLS). DIO mice (relative to controls) also had increased systemic inflammatory cytokines and decreased adipocyte expression of peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3) and other adipogenesis\u2010regulating genes. Supplementing the DIO diet with resveratrol prevented obesity\u2010associated increases in mammary tumor growth, mammary adipocyte hypertrophy, COX\u20102 expression, macrophage infiltration, CLS prevalence, and serum cytokines. Resveratrol also offset the obesity\u2010associated downregulation of adipocyte PPAR\u03b3 and other adipogenesis genes in DIO mice. Our findings suggest that resveratrol may inhibit obesity\u2010associated inflammation and claudin\u2010low breast cancer growth by inhibiting adipocyte hypertrophy and associated adipose tissue dysregulation that typically accompanies obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22763","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T13:38:40Z","timestamp":1511185120000},"page":"393-407","source":"Crossref","is-referenced-by-count":29,"title":["Resveratrol inhibits obesity\u2010associated adipose tissue dysfunction and tumor growth in a mouse model of postmenopausal claudin\u2010low breast cancer"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-1924","authenticated-orcid":false,"given":"Emily L.","family":"Rossi","sequence":"first","affiliation":[{"name":"Department of Nutrition University of North Carolina Chapel Hill North Carolina"},{"name":"Lineberger Comprehensive Cancer Center University of 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