{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:49:50Z","timestamp":1790459390536,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81460459"],"award-info":[{"award-number":["81460459"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>The role of N<jats:sup>6<\/jats:sup>\u2010methyladenosine (m<jats:sup>6<\/jats:sup>A) demethylase fat mass and obesity\u2010associated protein (FTO) in the regulation of chemo\u2010radiotherapy resistance remains largely unknown. Here, we show that the mRNA level of FTO is elevated in cervical squamous cell carcinoma (CSCC) tissues when compared with respective adjacent normal tissues. FTO enhances the chemo\u2010radiotherapy resistance both in vitro and in vivo through regulating expression of \u03b2\u2010catenin by reducing m<jats:sup>6<\/jats:sup>A levels in its mRNA transcripts and in turn increases excision repair cross\u2010complementation group 1 (ERCC1) activity. Clinically, the prognostic value of FTO for overall survival is found to be dependent on \u03b2\u2010catenin expression in human CSCC samples. Taken together, these findings uncover a critical function for FTO and its substrate m<jats:sup>6<\/jats:sup>A in the regulation of chemo\u2010radiotherapy resistance, which may bear potential clinical implications for CSCC treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22782","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T12:51:40Z","timestamp":1515588700000},"page":"590-597","source":"Crossref","is-referenced-by-count":319,"title":["FTO regulates the chemo\u2010radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting \u03b2\u2010catenin through mRNA demethylation"],"prefix":"10.1002","volume":"57","author":[{"given":"Shun","family":"Zhou","sequence":"first","affiliation":[{"name":"Graduated School Ningxia Medical University Yinchuan, Ningxia China"},{"name":"Department of Radiation Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital and Institute Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou\u2010Lan","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology General Hospital of Ningxia Medical University Yinchuan, Ningxia China"},{"name":"Cancer Institute Ningxia Medical University Yinchuan, Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Xia","sequence":"additional","affiliation":[{"name":"Graduated School Ningxia Medical University Yinchuan, Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine General Hospital of Ningxia Medical University Yinchuan, Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology General Hospital of Ningxia Medical University Yinchuan, Ningxia China"},{"name":"Cancer Institute Ningxia Medical University Yinchuan, Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3626-8319","authenticated-orcid":false,"given":"Yan\u2010Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology General Hospital of Ningxia Medical University Yinchuan, Ningxia China"},{"name":"Cancer Institute Ningxia Medical University Yinchuan, Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology General Hospital of Ningxia Medical University Yinchuan, Ningxia China"},{"name":"Cancer Institute Ningxia Medical University Yinchuan, Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30667"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.01.033"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2016.05.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.04.049"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.11.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1099"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.10.3971"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3724"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2012.12.006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2012.12.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14281"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1432"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.687"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.02.013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.059"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.11.017"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11743"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0410-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21671"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602883113"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4613"},{"key":"e_1_2_7_24_1","first-page":"13405","article-title":"Overexpression of the fat mass and obesity associated gene (FTO) in breast cancer and its clinical implications","volume":"8","author":"Tan A","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-337"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.11.004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2011.01279.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1276"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16064"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15748"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-016-0113-3"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2088"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-221"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2008.00481.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-014-3817-y"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016756"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgw047"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2012"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-015-9843-7"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.07.018"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.22782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.22782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:10:17Z","timestamp":1695539417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.22782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/mc.22782"],"URL":"https:\/\/doi.org\/10.1002\/mc.22782","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}