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However, 5\u2010FU resistance is common for many postoperative GC patients. Homeobox A13 (HOXA13) is a member of homeobox genes highly expressed in many human tumors. Its potential roles and mechanisms of resistance to 5\u2010FU in GC are poorly understood. In this study, we discovered that HOXA13 played an oncogenic role in vivo and in vitro. The patients with HOXA13 overexpression were closely related with poor prognosis and more prone to be resistant to 5\u2010FU. Moreover, dehydrogenase\/reductase 2 (DHRS2) was identified as a downstream gene of HOXA13. HOXA13 played a role of carcinogenesis through directly down\u2010regulating DHRS2 to increase MDM2. Furthermore, HOXA13 conferred 5\u2010FU resistance through MRP1 by a p53\u2010dependent pathway. Therefore, HOXA13 might serve as a potential signature that recognized patients who were insensitive to 5\u2010FU, and timely recommended them to other chemotherapy regimens.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22793","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T11:32:35Z","timestamp":1518521555000},"page":"722-734","source":"Crossref","is-referenced-by-count":43,"title":["HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5\u2010FU resistance by a p53\u2010dependent pathway"],"prefix":"10.1002","volume":"57","author":[{"given":"Yang","family":"Han","sequence":"first","affiliation":[{"name":"Department of General Surgery, Shanghai General Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shanghai General 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