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Recently, it was reported that a variety of cancer cell lines could be sensitized to DNA\u2010damage based chemotherapy drugs in combination with Triptolide treatment. In the present study, we show that a short time exposure (3\u2009h) to Triptolide, which did not trigger apoptosis, could specifically increase breast cancer cells sensitivity to Doxorubicin rather than other chemotherapy drugs including Paclitaxel, Fluorouracil, and Mitomycin C. Further studies revealed Triptolide downregulated ATM expression and inhibited DNA damage response to DNA double\u2010 strand breaks. Moreover, the chemosensitization effect to Doxorubicin from Triptolide was attenuated by overexpression of ATM in breast cancer cells. Our findings suggest that Triptolide specifically chemosensitizes breast cancer cells to Doxorubicin prior to apoptosis initiation through downregulating ATM expression and inhibiting DNA damage response.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22795","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T11:32:36Z","timestamp":1520076756000},"page":"807-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Triptolide sensitizes breast cancer cells to Doxorubicin through the DNA damage response inhibition"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-8966","authenticated-orcid":false,"given":"Yu","family":"Deng","sequence":"first","affiliation":[{"name":"School of Medicine Chengdu University Chengdu P.R 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