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Lactate dehydrogenase\u2010A (LDHA) can promote Warburg effect to produce lactate and Adenosine Triphosphate (ATP) in aerobic condition, which contributes to oncogenesis metastasis and drug resistance in various cancers. However, the expression and functional role of LDHA in GBC are largely unknown. We determined that LDHA was over\u2010expressed in GBC tumor tissues compared with normal tissues, which was also an independent prognostic factor for the overall survival of GBC patients by tissue microarrays analysis. In addition, RNAi\u2010mediated LDHA silencing could suppress the GBC cell proliferation, invasion, colony formation and glycolysis while promoting cell apoptosis in vitro. Similar results were observed in GBC cells treated with LDHA specific inhibitor FX11. Moreover, we confirmed that knockdown of LDHA could inhibit tumor growth in vivo. Additionally, we found that the 3\u2032\u2010untranslated region (3\u2032\u2010UTR) of LDHA mRNA was the direct target of microRNA\u201030d\u20105p (miR\u201030d\u20105p), which was low expressed in GBC tissues and associated with poor prognosis of GBC patients. Our findings disclose a novel role for miR\u201030d\u20105p\/LDHA axis contribute to aggressive progression by reprogramming the metabolic process in GBC cells, and suggest a potential application of miR\u201030d\u20105p\/LDHA axis in prognosis prediction and GBC treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22799","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T10:07:40Z","timestamp":1521799660000},"page":"772-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["LDHA is a direct target of miR\u201030d\u20105p and contributes to aggressive progression of gallbladder carcinoma"],"prefix":"10.1002","volume":"57","author":[{"given":"Yuting","family":"He","sequence":"first","affiliation":[{"name":"Precision Medicine Center The First Affiliated Hospital of Zhengzhou University Zhengzhou China"},{"name":"Key Laboratory of Clinical Medicine The First Affiliated Hospital of 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