{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T08:23:59Z","timestamp":1746433439579,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA131274","R01 ES011740"],"award-info":[{"award-number":["R01 CA131274","R01 ES011740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA014236"],"award-info":[{"award-number":["CA014236"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility. In this analysis of 349 newly diagnosed SCCHN patients and 295 cancer\u2010free controls, we investigated whether expression levels of eight core NER proteins were associated with risk of SCCHN. We quantified NER protein expression levels in cultured peripheral lymphocytes using a reverse\u2010phase protein microarray. Compared with the controls, SCCHN patients had statistically significantly lower expression levels of ERCC3 and XPA (<jats:italic>P\u2009<\/jats:italic>=\u20090.001 and 0.001, respectively). After dividing the subjects by controls\u2019 median values of expression levels, we found a dose\u2010dependent association between an increased risk of SCCHN and low expression levels of ERCC3 (adjusted OR, 1.75, and 95%\u2009CI: 1.26\u20102.42; <jats:italic>P<\/jats:italic><jats:sub>trend\u2009<\/jats:sub>=\u20090.008) and XPA (adjusted OR, 1.88; 95%\u2009CI, 1.35\u20102.60; <jats:italic>P<\/jats:italic><jats:sub>trend\u2009<\/jats:sub>=\u20090.001). We also identified a significant multiplicative interaction between smoking status and ERCC3 expression levels (<jats:italic>P<\/jats:italic>\u2009=\u20090.014). Finally, after integrating demographic and clinical variables, we found that the addition of ERCC3 and XPA expression levels to the model significantly improved the sensitivity of the expanded model on SCCHN risk. In conclusion, reduced protein expression levels of ERCC3 and XPA were associated with an increased risk of SCCHN. However, these results need to be confirmed in additional large studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22801","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T11:26:45Z","timestamp":1520854005000},"page":"784-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck"],"prefix":"10.1002","volume":"57","author":[{"given":"Peng","family":"Han","sequence":"first","affiliation":[{"name":"Duke Cancer Institute Duke University Medical Center Durham North Carolina"},{"name":"Department of Medicine Duke University School of Medicine Durham North Carolina"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery First Affiliated Hospital Xi'an Jiaotong University College of Medicine Xi'an Shaanxi P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Medical Center Durham North Carolina"},{"name":"Department of Medicine Duke University School of Medicine Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Shi","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Medical Center Durham North Carolina"},{"name":"Department of Medicine Duke University School of Medicine Durham North Carolina"},{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an Shaanxi P.R. 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Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose P.","family":"Zevallos","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Washington University School of Medicine St. Louis Missouri"},{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9505-1502","authenticated-orcid":false,"given":"Guojun","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Head and Neck Surgery The University of Texas M.D. Anderson Cancer Center Houston Texas"},{"name":"Department of Epidemiology The University of Texas M.D. Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich M.","family":"Sturgis","sequence":"additional","affiliation":[{"name":"Departments of Head 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