{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:57:01Z","timestamp":1760954221474,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672357","81472255","81472250"],"award-info":[{"award-number":["81672357","81472255","81472250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>POTE ankyrin domain family, member G (<jats:italic>poteg<\/jats:italic>) belongs to POTE family. The POTE family is composed of many proteins which are very closely related and expressed in prostate, ovary, testis, and placenta. Some POTE paralogs are related with some cancers. Here we showed that down\u2010regulation of POTEG was detected in about 60% primary esophageal squamous cell carcinoma (ESCC) tumor tissues. Clinical association studies determined that POTEG down\u2010regulation was significantly correlated with tumor differentiation, lymph nodes metastasis and TNM staging. Kaplan\u2010Meier analysis determined that POTEG down\u2010regulation was associated with poorer clinical outcomes of ESCC patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.026). Functional studies showed that POTEG overexpression could suppress tumor cell growth and metastasis capacity in vitro and in vivo. Molecular analyses revealed that POTEG downregulated CDKs, leading to subsequent inhibition of Rb phosphorylation, and consequently arrested Cell Cycle at G1\/S Checkpoint. POTEG overexpression induced apoptosis by activating caspases and PARP, and regulating canonical mitochondrial apoptotic pathways. On the other side, POTEG inhibited epithelial\u2010mesenchymal transition and suppressed tumor cell metastasis. In conclusion, our study reveals a functionally important control mechanism of POTEG in esophageal cancer pathogenesis, suggesting potential use in the ESCC intervention and therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22809","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T19:07:12Z","timestamp":1521745632000},"page":"886-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Down\u2010regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients"],"prefix":"10.1002","volume":"57","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"},{"name":"Guangdong Esophageal Cancer Institute Guangzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Zhan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojiao","family":"Ban","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghui","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingping","family":"Yun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Yuan","family":"Guan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"},{"name":"Department of Clinical Oncology The University of Hong Kong Hong Kong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-4083","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010sen University Cancer Center Guangzhou P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1314530"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.2308"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60643-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2663"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011201)92:11<2769::AID-CNCR10118>3.0.CO;2-M"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.05.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.262655399"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.09.045"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.07.045"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-009-0392-0"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800800518"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C"},{"key":"e_1_2_9_16_1","first-page":"767","article-title":"Aberrant promoter hypermethylation and silencing of the critical 3p21 tumour suppressor gene, RASSF1A, in Chinese oesophageal squamous cell carcinoma","volume":"28","author":"Wong ML","year":"2006","journal-title":"Int J Oncol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1150"},{"key":"e_1_2_9_18_1","article-title":"Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma","volume":"146","author":"Li Y","year":"2014","journal-title":"Gastroenterology"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.12.125"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3265"},{"key":"e_1_2_9_21_1","first-page":"278","article-title":"The C\u2010terminal common to group 3 POTES (CtG3P): a newly discovered nucleolar marker associated with malignant progression and metastasis","volume":"3","author":"Redfield SM","year":"2013","journal-title":"Am J Cancer Res"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2007.0079"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122792"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90539-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5293.1672"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209615"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.26510"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-015-0544-9"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.22809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.22809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:12:01Z","timestamp":1695485521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.22809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/mc.22809"],"URL":"https:\/\/doi.org\/10.1002\/mc.22809","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"type":"print","value":"0899-1987"},{"type":"electronic","value":"1098-2744"}],"subject":[],"published":{"date-parts":[[2018,4,6]]},"assertion":[{"value":"2017-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}