{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:23:24Z","timestamp":1768285404272,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T00:00:00Z","timestamp":1529107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673142"],"award-info":[{"award-number":["81673142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502032"],"award-info":[{"award-number":["81502032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772550"],"award-info":[{"award-number":["81772550"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2015206376"],"award-info":[{"award-number":["H2015206376"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:label\/><jats:p>p\u2010Hydroxylcinnamaldehyde isolated from the Cochinchina momordica seed (CMSP) has been identified to inhibit growth and metastasis in oesophageal squamous cell carcinoma (ESCC) by inducing differentiation. The aim of the present study was to evaluate the effect and underlying mechanism of CMSP on 4\u2010nitroquinoline 1\u2010oxide (4NQO)\u2010induced oesophageal tumourigenesis. In the present study, a mouse model of oesophageal preneoplastic lesions was established by providing 4NQO\u2010containing drinking water to C57BL\/6 mice. The effect of CMSP on tumourigenesis induced by the chemical mutagen and the effect of CMSP on immune function were investigated. The results showed that the incidence and pathological stage of atypical hyperplasia in oesophageal tissues were significantly reduced in CMSP\u2010treated mice compared with untreated mice. Immunohistochemistry and pull\u2010down assay results revealed that the expression levels of p\u2010ERK1\/2, p\u2010SAPK\/JNK, and GTP\u2010RhoA were significantly decreased in the oesophageal tissue of CMSP\u2010treated mice. In addition, the proportions of CD4<jats:sup>+<\/jats:sup> T cells, CD8<jats:sup>+<\/jats:sup> T cells, and NK cells were increased, while the proportion of CD4<jats:sup>+<\/jats:sup> CD25<jats:sup>+<\/jats:sup> regulatory T cells (Tregs) was decreased, in the peripheral blood of CMSP\u2010treated mice. These results indicated that CMSP could hamper 4NQO\u2010induced oesophageal tumourigenesis by regulating the RhoA\u2010ERK\/JNK signaling pathway and promoting immune system function, thus providing a new potential strategy for treating preneoplastic lesions of the oesophagus.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22847","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T10:21:59Z","timestamp":1528280519000},"page":"1319-1331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["p\u2010Hydroxylcinnamaldehyde slows the progression of 4NQO\u2010induced oesophageal tumourigenesis via the RhoA\u2010MAPK signaling pathway"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-9588","authenticated-orcid":false,"given":"Lianmei","family":"Zhao","sequence":"first","affiliation":[{"name":"Research Center The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Ma","sequence":"additional","affiliation":[{"name":"Research Center The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei PR China"},{"name":"Clinical Laboratory The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Research Center The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suli","family":"Dai","sequence":"additional","affiliation":[{"name":"Research Center The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Dong","sequence":"additional","affiliation":[{"name":"Research Center The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingjie","family":"Huo","sequence":"additional","affiliation":[{"name":"Research Center The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoen","family":"Shan","sequence":"additional","affiliation":[{"name":"Research Center The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_9_3_1","first-page":"241","article-title":"An analysis of incidence and mortality of esophageal cancer in China, 2003\u20132007","volume":"21","author":"Zhang SW","year":"2012","journal-title":"China Cancer"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13176"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.8.3795"},{"key":"e_1_2_9_6_1","first-page":"2708","article-title":"Inhibition effects of all trans\u2010retinoic acid on the growth and angiogenesis of esophagealsquamous cell carcinoma in nude mice","volume":"124","author":"Lu TY","year":"2011","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31315"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11703-007-0017-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12331"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29481"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00339-07"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116951"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-197"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0483"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.36"},{"key":"e_1_2_9_16_1","first-page":"2699","article-title":"Prognostic impact of tumor IL\u20106 expression after preoperative chemoradiotherapy in patients with advanced esophageal squamous cell carcinoma","volume":"33","author":"Yoneda M","year":"2013","journal-title":"Anticancer Res"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3714190"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v6.i5.112"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"7913","DOI":"10.18632\/oncotarget.6861","article-title":"The role of PD\u2010L1 in the radiation responseand prognosis for esophagealsquamous cell carcinoma related to IL\u20106 and T\u2010cell immunosuppression","volume":"7","author":"Chen MF","year":"2016","journal-title":"Oncotarget"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477301"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1664"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346528"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201600099"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181ad0fa2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.89"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002937"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.42"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.11756"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4562"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-7-71"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-075043"},{"key":"e_1_2_9_32_1","first-page":"1497","article-title":"Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin\u201027 mediated by retrovirus in human pancreatic carcinoma cells","volume":"27","author":"Liu L","year":"2012","journal-title":"Oncol Rep"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445580"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12949"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1640-8"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.07.003"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.22847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.22847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T17:06:45Z","timestamp":1694970405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.22847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,16]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/mc.22847"],"URL":"https:\/\/doi.org\/10.1002\/mc.22847","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,16]]},"assertion":[{"value":"2017-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}