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However, little is known regarding the effect of IH on cancer initiation. Here, the effect of IH on carcinogenesis was explored in azoxymethane (AOM) and dextran sodium sulfate (DSS)\u2010induced colon cancer models with three different protocols. In the first protocol, two other application time points (early or late initiation of IH) were applied. In the second protocol, mice were divided into only two groups, and then exposed to either N or IH conditions for 14 days. In the third protocol, a pharmacological inhibition study for anti\u2010inflammation (5\u2010aminosalicylate) or anti\u2010oxidative stress (N\u2010acetylcysteine [NAC]) was performed. The number of tumors was significantly higher in the IH\u20101 than in the N or IH\u20102 groups. 8\u2010oxo\u20102\u2032\u2010deoxyguanosine (8\u2010OHdG) levels were higher in tumors of the IH\u20101 group than in that of the N and IH\u20102 groups. Gene expression related to reactive oxygen species production was higher in the IH\u20101 group than in the N and IH\u20102 groups, and it showed a positive correlation with 8\u2010OHdG levels. Prior to cancer development 8\u2010OHdG levels were already elevated in colonic epithelial regions in the IH group, possibly due to an imbalance between oxidative stress and antioxidant systems. NAC treatment resulted in a significant reduction in the number of tumors in mice exposed to IH. In conclusion, IH promotes carcinogenesis in a chemically\u2010induced colon cancer model where elevated 8\u2010OHdG may contribute to the increased tumor induction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mc.22957","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T20:39:33Z","timestamp":1545424773000},"page":"654-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intermittent hypoxia promotes carcinogenesis in azoxymethane and dextran sodium sulfate\u2010induced colon cancer model"],"prefix":"10.1002","volume":"58","author":[{"given":"Dae Wui","family":"Yoon","sequence":"first","affiliation":[{"name":"Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology Seoul National University College of Medicine Seoul 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