{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:56:34Z","timestamp":1789131394515,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Indiana University Health Value Grant","award":["VFR-415-Zhang"],"award-info":[{"award-number":["VFR-415-Zhang"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>ERG (avian v\u2010ets erythroblastosis virus E26 oncogene homolog), an oncoprotein in prostate carcinoma and Ewing's sarcoma is associated with poor prognosis in patients with acute myeloid leukemia and T lymphoblastic leukemia. However little is known about ERG in lymphoma. Here we studied ERG in diffuse large B\u2010cell lymphoma (DLBCL) by immunohistochemistry, fluorescence in situ hybridization (FISH), genome\u2010wide microRNA (miRNA) expression profiling, real\u2010time reverse\u2010transcriptase polymerase chain reaction (RT\u2010PCR) and whole exome sequencing (WES). Approximately 30% of de novo DLBCLs (37 of 118) expressed ERG (ERG+). ERG expression showed no significant correlation with DLBCL cell\u2010of\u2010origin classification, patient's age, sex, nodal, or extranodal disease status, tumor expression of p53 or p63. There was no <jats:italic>ERG<\/jats:italic> rearrangement in 10 randomly selected ERG+ DLBCLs by FISH. Forty\u2010three miRNAs showed significant differential expression between ERG+ and ERG\u2212 DLBCLs. Downregulation of miR\u20104638\u20105p was confirmed by real\u2010time RT\u2010PCR. WES not only confirmed known gene mutations in DLBCLs but also revealed multiple novel gene mutations in <jats:italic>POLA1<\/jats:italic>, <jats:italic>E2F1<\/jats:italic>, <jats:italic>PSMD8<\/jats:italic>, <jats:italic>AXIN1<\/jats:italic>, <jats:italic>GAB2<\/jats:italic>, and <jats:italic>GNB2L1<\/jats:italic>, which occur more frequently in ERG+ DLBCLs. In conclusion, our studies demonstrated aberrant ERG expression in a subset of DLBCL, which is associated with downregulation of miR\u20104638\u20105p. In comparison with ERG\u2010negative DLBCL, ERG+ DLBCL more likely harbors mutations in genes important in cell cycle control, B\u2010cell receptor\u2010mediated signaling and degradation of \u03b2\u2010catenin. Further clinicopathological correlation and functional studies of ERG\u2010related miRNAs and pathways may provide new insight into the pathogenesis of DLBCL and reveal novel targets for better management of patients with DLBCL.<\/jats:p>","DOI":"10.1002\/mc.23074","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T18:47:44Z","timestamp":1561488464000},"page":"1846-1854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aberrant ERG expression associates with downregulation of miR\u20104638\u20105p and selected genomic alterations in a subset of diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8525-7021","authenticated-orcid":false,"given":"Shanxiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Indiana University School of Medicine  Indianapolis 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