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Nonetheless, its contribution in Latino populations specifically among Mexican men, where 70% of PC cases are detected in advanced stages, is still unknown. The contribution of seven polymorphisms in <jats:italic>BRCA<\/jats:italic>1\/2 and <jats:italic>VDR<\/jats:italic> genes to PC susceptibility was evaluated in 370 incident PC cases and 759 age\u2010matched (\u00b15 years) controls belonging to the Mexican population. Based on Gleason score at diagnosis, PC cases were classified as well\u2010differentiated PC (Gleason &lt;7) and moderate or poorly differentiated PC (Gleason \u22657). Age at diagnosis was used to divided PC cases in earlier (&lt;60 years) and late\u2010onset PC (\u226560 years). Prostate and breast cancer family histories were obtained through interview. Our results provided evidences about the contribution of <jats:italic>BRCA1<\/jats:italic>\u2010rs1799966 (OR<jats:sub><jats:italic>CC<\/jats:italic> genotype<\/jats:sub>\u2009=\u20092.30; 95% confidence interval [CI]\u2009=\u20091.36\u20103.91) to the moderate or poorly differentiated PC risk, independently of the family history of prostate, breast or ovary cancer. Further, <jats:italic>VDR<\/jats:italic>\u2010rs2238135\u2010G allele was associated with early\u2010onset PC (OR<jats:sub><jats:italic>G<\/jats:italic> allele<\/jats:sub>\u2009=\u20092.05; 95% CI\u2009=\u20091.06\u20103.95), and marginally with moderate or poorly differentiated PC risk. The present study revealed the crucial role of <jats:italic>BRCA1<\/jats:italic> in PC aggressiveness risk, outstanding the gender imbalance regarding the breast cancer risk in women.<\/jats:p>","DOI":"10.1002\/mc.23187","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T05:10:46Z","timestamp":1585285846000},"page":"629-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>BRCA1<\/i> and <i>VDR<\/i> gene polymorphisms are associated with prostate cancer risk in Mexican men"],"prefix":"10.1002","volume":"59","author":[{"given":"Gabriela Ang\u00e9lica","family":"Mart\u00ednez\u2010Nava","sequence":"first","affiliation":[{"name":"Synovial Liquid Laboratory National Institute of Rehabilitation \u201cLuis Guillermo Ibarra Ibarra\u201d (INR)  Mexico City Mexico"},{"name":"Research Center for Infectious Diseases (CISEI), Genetic Epidemiology Department National Institute of Public Health (INSP)  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Toxicology Department Cinvestav\u2010IPN  Mexico City Mexico City M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Burguete\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Research Center for Infectious Diseases (CISEI), Genetic Epidemiology Department National Institute of Public Health (INSP)  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Argelia","family":"V\u00e1zquez\u2010Salas","sequence":"additional","affiliation":[{"name":"Population Health Research Center (CISP), Reproductive Health (INSP) National Institute of Public Health\/CONACYT  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Ventura\u2010Bahena","sequence":"additional","affiliation":[{"name":"Population Health Research Center (CISP), Reproductive Health department National Institute of Public Health (INSP)  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-9881","authenticated-orcid":false,"given":"Luisa","family":"Torres\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Population Health Research Center (CISP), Reproductive Health department National Institute of Public Health (INSP)  Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.10.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.02193.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/928562"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/318787"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-016-9875-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.1882"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2871"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.01.003"},{"key":"e_1_2_9_11_1","first-page":"129","article-title":"Role of vitamin D metabolism and activity on carcinogenesis","volume":"22","author":"Xiay W","year":"2014","journal-title":"Oncol Res"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00958-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp103"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp055"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-9-84"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0487"},{"key":"e_1_2_9_17_1","first-page":"1395","article-title":"A. 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