{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:31:17Z","timestamp":1790483477649,"version":"4.1.0"},"reference-count":135,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\u2010P01\u2010CA225517"],"award-info":[{"award-number":["NIH\u2010P01\u2010CA225517"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH\u2010T32\u2010CA080416"],"award-info":[{"award-number":["NIH\u2010T32\u2010CA080416"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Great strides have been made in cancer immunotherapy including the breakthrough successes of anti\u2010PD\u2010(L)1 checkpoint inhibitors. In Merkel cell carcinoma (MCC), a rare and aggressive skin cancer, PD\u2010(L)1 blockade is highly effective. Yet, ~50% of patients either do not respond to therapy or develop PD\u2010(L)1 refractory disease and, thus, do not experience long\u2010term benefit. For these patients, additional or combination therapies are needed to augment immune responses that target and eliminate cancer cells. Therapeutic vaccines targeting tumor\u2010associated antigens, mutated self\u2010antigens, or immunogenic viral oncoproteins are currently being developed to augment T\u2010cell responses. Approximately 80% of MCC cases in the United States are driven by the ongoing expression of viral T\u2010antigen (T\u2010Ag) oncoproteins from genomically integrated Merkel cell polyomavirus (MCPyV). Since T\u2010Ag elicits specific B\u2010 and T\u2010cell immune responses in most persons with virus\u2010positive MCC (VP\u2010MCC), and ongoing T\u2010Ag expression is required to drive VP\u2010MCC cell proliferation, therapeutic vaccination with T\u2010Ag is a rational potential component of immunotherapy. Failure of the endogenous T\u2010cell response to clear VP\u2010MCC (allowing clinically evident tumors to arise) implies that therapeutic vaccination will need to be potent an\u015bd synergize with other mechanisms to enhance T\u2010cell activity against tumor cells. Here, we review the relevant underlying biology of VP\u2010MCC, potentially applicable therapeutic vaccine platforms, and antigen delivery formats. We also describe early successes in the field of therapeutic cancer vaccines and address several clinical scenarios in which VP\u2010MCC patients could potentially benefit from a therapeutic vaccine.<\/jats:p>","DOI":"10.1002\/mc.23190","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T07:39:46Z","timestamp":1585294786000},"page":"807-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Polyomavirus\u2010driven Merkel cell carcinoma: Prospects for therapeutic vaccine development"],"prefix":"10.1002","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1595-4619","authenticated-orcid":false,"given":"Shira","family":"Tabachnick\u2010Cherny","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Dermatology University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3511-6348","authenticated-orcid":false,"given":"Thomas","family":"Pulliam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-8292","authenticated-orcid":false,"given":"Candice","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology University of Washington  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1255-9023","authenticated-orcid":false,"given":"David M.","family":"Koelle","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy and Infectious Diseases University of Washington  Seattle Washington"},{"name":"Translational Research Program Benaroya Research Institute at Virginia Mason  Seattle Washington"},{"name":"Department of Laboratory Medicine University of Washington  Seattle Washington"},{"name":"Department of Global Health University of Washington  Seattle Washington"},{"name":"Vaccine and Infectious Diseases Division Fred Hutchinson Cancer Research Center  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-963X","authenticated-orcid":false,"given":"Paul","family":"Nghiem","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology University of Washington  Seattle Washington"},{"name":"Seattle Cancer Care Alliance  Seattle Washington"},{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0103-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5266-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2010.01.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2017.05.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.028"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152586"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6494"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1877"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.10.015"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-015-2343-0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12122"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.05.006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.04.024"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000578"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp332"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30475"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.192856"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2697"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2128"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1922-8"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1906-8"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05548-y"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0404-0"},{"issue":"11","key":"e_1_2_11_25_1","first-page":"7610","article-title":"Prognostic value of immune cell infiltration, tertiary lymphoid structures and PD\u2010L1 expression in Merkel cell carcinomas","volume":"7","author":"Behr DS","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603702"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46323"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02400-09"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29200"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02916-13"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.05.007"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806526105"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3291"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.06.008"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007543"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818798116"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1513"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0035"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0210"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06300-3"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2019.103961"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.6308"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPIKDZM39CRPNC"},{"key":"e_1_2_11_44_1","first-page":"canimm.0647.201","article-title":"High prevalence and diverse HLA restriction of intratumoral oncoprotein\u2010specific CD8 T cells in polyoma virus\u2010driven Merkel cell carcinoma","author":"Jing L","year":"2020","journal-title":"Cancer Immunology Research"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-19-0103"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.02.006"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.10.009"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1129"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0441-y"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-019-0103-y"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e3182829903"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006034"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0087"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603800"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22991"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0792-9"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2009.148"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61591-3"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80242-9"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810097"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-200403000-00006"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00239-1"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02315-x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.11.017"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.adgen.2014.10.005"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.1.148"},{"issue":"2","key":"e_1_2_11_67_1","first-page":"144","article-title":"Phase I study with an autologous tumor cell vaccine for locally advanced or metastatic prostate cancer","volume":"10","author":"Berger M","year":"2007","journal-title":"J Pharm Pharm Sci"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e31815ba792"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.5252"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117208109"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2121"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.4244"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.04.041"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0469"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0972"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.3377"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.14338\/IJPT-18-00012.1"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.176"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-012-1292-7"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4051"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2368"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0223"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45416"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0390-x"},{"key":"e_1_2_11_85_1","article-title":"Abstract: Lysosomal\u2010associated membrane protein\u20101\u2010targeting of the large T antigen of Merkel cell polomavirus elicits potent CD4\u2009+\u2009T cell responses","author":"Heiland T","year":"2019","journal-title":"First International Symposium on Merkel Cell Carcinoma"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3446"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-3-29"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-2-36"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.12.072"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2017.1329070"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.289"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e31815ce501"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix592"},{"key":"e_1_2_11_94_1","doi-asserted-by":"crossref","unstructured":"ServickK.This mysterious $2 billion biotech is revealing the secrets behind its new drugs and vaccines.Science: AAAS. Feb 1 2017.http:\/\/doi.org\/10.1126\/science.aal0686","DOI":"10.1126\/science.aal0686"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016819"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301885"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.173.23.7481-7490.1991"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.12.013"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1116"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.4001944"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00410"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.9.5946"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07186-4"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15590-6"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-3126"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1257"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14356"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.107"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.019"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.017"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa4306"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.04.005"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300555"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406498"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23003"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox026"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2018.10.004"},{"key":"e_1_2_11_118_1","first-page":"Cd009069","article-title":"Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors","volume":"5","author":"Arbyn M","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.2741\/2739"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.04.026"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2019.1629259"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00048-9"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-88"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2015.40"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1143"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1147641"},{"key":"e_1_2_11_127_1","unstructured":"NCCN. Merkel cell carcinoma (Version 2.2019).https:\/\/merkelcell.org\/wp\u2010content\/uploads\/2017\/10\/MCC_v.2.2019\u20102.pdf. Accessed 31 January 2020."},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.77"},{"issue":"13","key":"e_1_2_11_129_1","doi-asserted-by":"crossref","first-page":"CT074","DOI":"10.1158\/1538-7445.AM2017-CT074","article-title":"Abstract CT074: non\u2010comparative, open\u2010label, multiple cohort, phase 1\/2 study to evaluate nivolumab (NIVO) in patients with virus\u2010associated tumors (CheckMate 358): efficacy and safety in Merkel cell carcinoma (MCC)","volume":"77","author":"Topalian SL","year":"2017","journal-title":"Cancer Res"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01896"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(01)00032-6"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.07.003"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw5680"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0820"},{"key":"e_1_2_11_135_1","unstructured":"Sp. K Sample size calculator.https:\/\/clincalc.com\/stats\/samplesize.aspx. Accessed February 6 2020."},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30364-3"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.23190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.23190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mc.23190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.23190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T05:04:57Z","timestamp":1693976697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.23190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,27]]},"references-count":135,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/mc.23190"],"URL":"https:\/\/doi.org\/10.1002\/mc.23190","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,27]]},"assertion":[{"value":"2020-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}